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DESI1 desumoylating isopeptidase 1 [ Homo sapiens (human) ]

Gene ID: 27351, updated on 23-Nov-2021

Summary

Official Symbol
DESI1provided by HGNC
Official Full Name
desumoylating isopeptidase 1provided by HGNC
Primary source
HGNC:HGNC:24577
See related
Ensembl:ENSG00000100418 MIM:614637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POST; DESI2; DeSI-1; PPPDE2; FAM152B; D15Wsu75e; DJ347H13.4
Expression
Ubiquitous expression in testis (RPKM 7.4), esophagus (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

See DESI1 in Genome Data Viewer
Location:
22q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (41598028..41621077, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41994032..42017047, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3167 Neighboring gene cold shock domain containing C2 Neighboring gene phosphomannomutase 1 Neighboring gene X-ray repair cross complementing 6 Neighboring gene protein LLP homolog pseudogene Neighboring gene small nuclear ribonucleoprotein 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138384

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO-specific isopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables importin-alpha family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
desumoylating isopeptidase 1
Names
PPPDE peptidase domain containing 2
PPPDE peptidase domain-containing protein 2
desumoylating isopeptidase 2
family with sequence similarity 152, member B
polyubiquitinated substrate transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015704.3NP_056519.1  desumoylating isopeptidase 1

    See identical proteins and their annotated locations for NP_056519.1

    Status: VALIDATED

    Source sequence(s)
    AL023553, BC039554, BC093956, BX403547, BX478162
    Consensus CDS
    CCDS33652.1
    UniProtKB/Swiss-Prot
    Q6ICB0
    Related
    ENSP00000263256.6, ENST00000263256.7
    Conserved Domains (1) summary
    pfam05903
    Location:7149
    Peptidase_C97; PPPDE putative peptidase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    41598028..41621077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261571.4XP_005261628.1  desumoylating isopeptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005261628.1

    Conserved Domains (1) summary
    pfam05903
    Location:7144
    Peptidase_C97; PPPDE putative peptidase domain

RNA

  1. XR_001755216.1 RNA Sequence

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