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APOBEC3C apolipoprotein B mRNA editing enzyme catalytic subunit 3C [ Homo sapiens (human) ]

Gene ID: 27350, updated on 5-Dec-2021

Summary

Official Symbol
APOBEC3Cprovided by HGNC
Official Full Name
apolipoprotein B mRNA editing enzyme catalytic subunit 3Cprovided by HGNC
Primary source
HGNC:HGNC:17353
See related
Ensembl:ENSG00000244509 MIM:607750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3
Summary
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 33.1), testis (RPKM 26.8) and 24 other tissues See more
Orthologs
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Genomic context

See APOBEC3C in Genome Data Viewer
Location:
22q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (39014257..39020352)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39410262..39416357)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985562 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3B Neighboring gene APOBEC3B antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 8537 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3F Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3D Neighboring gene uncharacterized LOC107985563

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Single-virion fluorescence microscopy analysis demonstrates that the efficiency of A3G-YFP and A3F-YFP incorporation into HIV-1 Gag-CeFP virions is higher than that of A3C-YFP incorporation into HIV-1 Gag-CeFP virions PubMed
gag Interaction of APOBEC3C with HIV-1 Gag is required for its incorporation into Vif(-) virions and the interaction between APOBEC3C and Gag is MA domain-dependent and 7SL RNA-dependent PubMed
Vif vif HIV-1 Vif degrades APOBEC3C and APOBEC3F and is dependent on Vif F1, F2, and F3 box mutations involving residues D14, R15, M16, W79, D172, and W174 PubMed
vif HIV-1 Vif degrades APOBEC3F and APOBEC3C PubMed
vif HIV-1 Vif internal amino acid salt bridge (E171-K167-D101) mediates human APOBEC3C and APOBEC3F degradation PubMed
vif APOBEC3C restricts HIV-1 replication by causing G to A mutations in viral DNA replication intermediates; HIV-1 Vif binds to and destabilizes APOBEC3C PubMed
vif APOBEC3C levels in virus particles are increased when the virus particles are produced from N.41 treated 293T cells in the presence of Vif expression PubMed
vif Immunoblotting and crystal structure analyses reveal ten amino acids L72, F75, C76, I79, L80, S81, Y86, E106, F107, and H111 between the alpha 2 and alpha 3 helices of APOBEC3C are involved in forming the Vif-interaction interface PubMed
vif CBF-beta-mediated increase of HIV-1 Vif steady-state levels results in decreased cellular levels of all Vif-sensitive APOBEC proteins (A3C, A3D, A3F, A3G, and A3H haplotype II) PubMed
vif A potent small molecular compound VEC-5 protects APOBEC3G, APOBEC3F, and APOBEC3C from HIV-1 Vif-induced degradation and enhances A3G incorporation into HIV-1 virions by inhibiting the interaction between Vif and elongin C PubMed
vif Stress causes A3A, A3B, A3C, and A3F to co-localize efficiently with Vif(IIIB) and mRNA-PABP1 complexes in stress granules PubMed
vif Vif(IIIB) induces A3A, A3B, and A3C emigration from the nucleus to the cytosol and thereby causes net increases in their cytosolic concentrations and anti-HIV-1 activities PubMed
vif Small molecule RN-18 specifically inhibits HIV-1 Vif-mediated downregulation of APOBEC3C/F/G proteins by decreasing Vif protein levels when Vif interacts with these proteins PubMed
vif A novel conserved 69YXXL72 motif in HIV-1 Vif regulates A3C expression in cells PubMed
vif The LV portion of the Vif SLV/Ix4Yx9Y motif is required for optimal suppression of A3C or A3DE PubMed
vif HIV-1 Vif K22E and RH41/42AA mutants are able to suppress the anti-viral activity of A3C, but are ineffective in suppressing the anti-viral activity of A3G. K22, R41, and H42 residues are important for Vif-mediated degradation of A3G, but not A3C PubMed
vif Amino acid E289 in the EFLARH sequence of A3C is critical for HIV-1 Vif-mediated degradation PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of APOBEC3C in human monocyte-derived macrophages PubMed
matrix gag Interaction of APOBEC3C with HIV-1 Gag is required for its incorporation into Vif(-) virions and the interaction between APOBEC3C and Gag is MA domain-dependent and 7SL RNA-dependent PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37251, MGC19485

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deoxycytidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA cytosine deamination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA demethylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytidine deamination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytidine to uridine editing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transposition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transposition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA dC->dU-editing enzyme APOBEC-3C
Names
apolipoprotein B editing enzyme catalytic polypeptide-like 3C
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
phorbolin I
probable DNA dC->dU-editing enzyme APOBEC-3C
NP_055323.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014508.3NP_055323.2  DNA dC->dU-editing enzyme APOBEC-3C

    See identical proteins and their annotated locations for NP_055323.2

    Status: REVIEWED

    Source sequence(s)
    AL022318
    Consensus CDS
    CCDS13983.1
    UniProtKB/Swiss-Prot
    Q9NRW3
    Related
    ENSP00000355340.3, ENST00000361441.5
    Conserved Domains (1) summary
    pfam18772
    Location:12190
    APOBEC2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    39014257..39020352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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