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KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 [ Homo sapiens (human) ]

Gene ID: 27345, updated on 13-Mar-2020

Summary

Official Symbol
KCNMB4provided by HGNC
Official Full Name
potassium calcium-activated channel subfamily M regulatory beta subunit 4provided by HGNC
Primary source
HGNC:HGNC:6289
See related
Ensembl:ENSG00000135643 MIM:605223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 7.6), adrenal (RPKM 4.7) and 15 other tissues See more
Orthologs

Genomic context

See KCNMB4 in Genome Data Viewer
Location:
12q15
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (70366220..70434292)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (70760062..70828072)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2821 Neighboring gene progenitor renewal associated non-coding RNA Neighboring gene CCR4-NOT transcription complex subunit 2 Neighboring gene RNA, U4 small nuclear 65, pseudogene Neighboring gene uncharacterized LOC105369827

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
action potential IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
detection of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
neuronal action potential IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neurotransmitter secretion TAS
Traceable Author Statement
more info
PubMed 
regulation of vasoconstriction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium-activated potassium channel subunit beta-4
Names
BK channel beta subunit 4
BK channel subunit beta-4
BKbeta4
MaxiK channel beta-subunit 4
big potassium channel beta subunit 4
calcium-activated potassium channel, subfamily M subunit beta-4
charybdotoxin receptor subunit beta-4
hbeta4
k(VCA)beta-4
large conductance calcium-dependent potassium ion channel beta 4 subunit
maxi K channel subunit beta-4
potassium channel subfamily M regulatory beta subunit 4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
slo-beta-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014505.6NP_055320.4  calcium-activated potassium channel subunit beta-4

    See identical proteins and their annotated locations for NP_055320.4

    Status: REVIEWED

    Source sequence(s)
    AC025569, BC042446
    Consensus CDS
    CCDS8997.1
    UniProtKB/Swiss-Prot
    Q86W47
    Related
    ENSP00000258111.4, ENST00000258111.5
    Conserved Domains (1) summary
    pfam03185
    Location:8203
    CaKB; Calcium-activated potassium channel, beta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    70366220..70434292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538188.2XP_011536490.1  calcium-activated potassium channel subunit beta-4 isoform X1

    Conserved Domains (1) summary
    pfam03185
    Location:8155
    CaKB; Calcium-activated potassium channel, beta subunit

RNA

  1. XR_245917.4 RNA Sequence

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