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PRPF19 pre-mRNA processing factor 19 [ Homo sapiens (human) ]

Gene ID: 27339, updated on 7-Jun-2020

Summary

Official Symbol
PRPF19provided by HGNC
Official Full Name
pre-mRNA processing factor 19provided by HGNC
Primary source
HGNC:HGNC:17896
See related
Ensembl:ENSG00000110107 MIM:608330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200
Summary
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]
Expression
Ubiquitous expression in brain (RPKM 44.9), ovary (RPKM 35.1) and 25 other tissues See more
Orthologs

Genomic context

See PRPF19 in Genome Data Viewer
Location:
11q12.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60890547..60906585, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60658019..60674061, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 86 Neighboring gene prostaglandin D2 receptor 2 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene uncharacterized LOC107984333 Neighboring gene uncharacterized LOC105369323

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, pre-mRNA processing factor 19 homolog (PRPF19), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PRPF19 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
generation of catalytic spliceosome for first transesterification step IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner cell mass cell proliferation IEA
Inferred from Electronic Annotation
more info
 
lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
positive regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction involved in DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
spliceosomal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
spliceosomal tri-snRNP complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with DNA replication factor A complex IDA
Inferred from Direct Assay
more info
PubMed 
Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Prp19 complex IDA
Inferred from Direct Assay
more info
PubMed 
U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pre-mRNA-processing factor 19
Names
PRP19/PSO4 homolog
PRP19/PSO4 pre-mRNA processing factor 19 homolog
RING-type E3 ubiquitin transferase PRP19
nuclear matrix protein 200
nuclear matrix protein NMP200 related to splicing factor PRP19
psoralen 4
senescence evasion factor
NP_055317.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014502.5NP_055317.1  pre-mRNA-processing factor 19

    See identical proteins and their annotated locations for NP_055317.1

    Status: VALIDATED

    Source sequence(s)
    AL555169, AP000777, AP003721, AW673738
    Consensus CDS
    CCDS7995.1
    UniProtKB/Swiss-Prot
    Q9UMS4
    Related
    ENSP00000227524.4, ENST00000227524.9
    Conserved Domains (4) summary
    cd00200
    Location:223503
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:224262
    7WD40; WD40 repeat [structural motif]
    cd16656
    Location:456
    RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
    pfam08606
    Location:69133
    Prp19; Prp19/Pso4-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60890547..60906585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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