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PRPF19 pre-mRNA processing factor 19 [ Homo sapiens (human) ]

Gene ID: 27339, updated on 7-Jul-2024

Summary

Official Symbol
PRPF19provided by HGNC
Official Full Name
pre-mRNA processing factor 19provided by HGNC
Primary source
HGNC:HGNC:17896
See related
Ensembl:ENSG00000110107 MIM:608330; AllianceGenome:HGNC:17896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200
Summary
Enables identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in several processes, including DNA damage checkpoint signaling; cellular protein metabolic process; and mRNA splicing, via spliceosome. Acts upstream of or within protein polyubiquitination. Located in cytoplasm; nuclear speck; and site of double-strand break. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. Colocalizes with DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 44.9), ovary (RPKM 35.1) and 25 other tissues See more
Orthologs
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Genomic context

See PRPF19 in Genome Data Viewer
Location:
11q12.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (60890547..60906585, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (60841704..60857730, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60658019..60674057, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CCDC86 antisense RNA 1 Neighboring gene coiled-coil domain containing 86 Neighboring gene prostaglandin D2 receptor 2 Neighboring gene Sharpr-MPRA regulatory region 12454 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:60666609-60667134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:60673689-60674276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4781 Neighboring gene PRPF19 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60679869-60680867 Neighboring gene TMEM109 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, pre-mRNA processing factor 19 homolog (PRPF19), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PRPF19 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of DNA replication factor A complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Prp19 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
pre-mRNA-processing factor 19
Names
PRP19/PSO4 homolog
PRP19/PSO4 pre-mRNA processing factor 19 homolog
RING-type E3 ubiquitin transferase PRP19
nuclear matrix protein 200
nuclear matrix protein NMP200 related to splicing factor PRP19
psoralen 4
senescence evasion factor
NP_055317.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014502.5NP_055317.1  pre-mRNA-processing factor 19

    See identical proteins and their annotated locations for NP_055317.1

    Status: VALIDATED

    Source sequence(s)
    AL555169, AP000777, AP003721, AW673738
    Consensus CDS
    CCDS7995.1
    UniProtKB/Swiss-Prot
    Q9UMS4
    Related
    ENSP00000227524.4, ENST00000227524.9
    Conserved Domains (4) summary
    cd00200
    Location:223503
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:224262
    7WD40; WD40 repeat [structural motif]
    cd16656
    Location:456
    RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
    pfam08606
    Location:69133
    Prp19; Prp19/Pso4-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    60890547..60906585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    60841704..60857730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)