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EIF3K eukaryotic translation initiation factor 3 subunit K [ Homo sapiens (human) ]

Gene ID: 27335, updated on 21-Mar-2023

Summary

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Official Symbol
EIF3Kprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Kprovided by HGNC
Primary source
HGNC:HGNC:24656
See related
Ensembl:ENSG00000178982 MIM:609596; AllianceGenome:HGNC:24656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M9; ARG134; PLAC24; PTD001; EIF3S12; HSPC029; MSTP001; PLAC-24; PRO1474; EIF3-p28
Summary
The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in heart (RPKM 136.4), duodenum (RPKM 100.7) and 25 other tissues See more
Orthologs
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Genomic context

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See EIF3K in Genome Data Viewer
Location:
19q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38619188..38636954)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41423166..41440932)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39109828..39127594)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 1 Neighboring gene uncharacterized LOC124904710 Neighboring gene MAP4K1 antisense RNA 1 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1 Neighboring gene Sharpr-MPRA regulatory region 11915 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39156419-39157108 Neighboring gene actinin alpha 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The translation initiation factor 3 subunit eIF3K interacts with PML and associates with PML nuclear bodies. Salsman J, et al. Exp Cell Res, 2013 Oct 15. PMID 24036361
  2. Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3. Shen X, et al. FEBS Lett, 2004 Aug 27. PMID 15327989
  3. Crystal structure of human eIF3k, the first structure of eIF3 subunits. Wei Z, et al. J Biol Chem, 2004 Aug 13. PMID 15180986
  4. Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively. Herrmannová A, et al. Nucleic Acids Res, 2020 Feb 28. PMID 31863585, Free PMC Article
  5. PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact. Karki S, et al. Mol Biol Cell, 2002 May. PMID 12006665, Free PMC Article

See all (108) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whereas the eIF3c knockdown reduces it, downregulation of eIF3k or eIF3l increases mRNA recruitment, suggesting that the latter subunits possess a regulatory potential. Altogether this study provides new insights into the role of human eIF3 in the initial assembly steps of the translational machinery
    Title: Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.
  2. eIF3K subunit interacts directly with the PML protein.
    Title: The translation initiation factor 3 subunit eIF3K interacts with PML and associates with PML nuclear bodies.
  3. eIF3k, originally identified as the smallest subunit of eukaryotic translation initiation factor 3 (eIF3) complexes, also localizes to keratin intermediate filaments and physically associates with K18 in epithelial cells.
    Title: eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions.
  4. eIF3k has three putative protein-binding surfaces and has potential RNA binding activity
    Title: Crystal structure of human eIF3k, the first structure of eIF3 subunits.
  5. cyclin D3 specifically interacted with eIF3k through its C-terminal domain; eIF3k distributed both in nucleus and cytoplasm and colocalized with cyclin D3
    Title: Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3.
  6. identification of a novel 24-kDa protein that binds directly to dynein intermediate chain [PLAC-24]
    Title: PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit K (EIF3K) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit K (EIF3K) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
 PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IC
Inferred by Curator
more info
 PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit K
Names
eIF-3 p28
eukaryotic translation initiation factor 3, subunit 12
muscle specific
muscle-specific gene M9 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300992.2 → NP_001287921.1  eukaryotic translation initiation factor 3 subunit K isoform 2

    See identical proteins and their annotated locations for NP_001287921.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    BG470776, BG943109, JX870647
    Consensus CDS
    CCDS74360.1
    UniProtKB/TrEMBL
    K7ERF1, U3LUI4
    Related
    ENSP00000468231.1, ENST00000592558.1
    Conserved Domains (1) summary
    cl24019
    Location:61 → 163
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  2. NM_001308393.2 → NP_001295322.1  eukaryotic translation initiation factor 3 subunit K isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AI054400, BG488547, BG943109
    Consensus CDS
    CCDS77293.1
    UniProtKB/TrEMBL
    K7EK53
    Related
    ENSP00000465460.1, ENST00000593149.5
    Conserved Domains (1) summary
    cl24019
    Location:1 → 102
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

  3. NM_013234.4 → NP_037366.1  eukaryotic translation initiation factor 3 subunit K isoform 1

    See identical proteins and their annotated locations for NP_037366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC001031, BG943109
    Consensus CDS
    CCDS12517.1
    UniProtKB/Swiss-Prot
    Q9UBQ5, Q9Y6D1
    Related
    ENSP00000248342.3, ENST00000248342.9
    Conserved Domains (1) summary
    pfam10075
    Location:61 → 189
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    38619188..38636954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p14 PATCHES

    Range
    28824..46590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41423166..41440932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UBQ5.1 GenPept UniProtKB/Swiss-Prot:Q9UBQ5

Gene LinkOut

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