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P2RY10 P2Y receptor family member 10 [ Homo sapiens (human) ]

Gene ID: 27334, updated on 4-Jun-2020

Summary

Official Symbol
P2RY10provided by HGNC
Official Full Name
P2Y receptor family member 10provided by HGNC
Primary source
HGNC:HGNC:19906
See related
Ensembl:ENSG00000078589 MIM:300529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2Y10; LYPSR2
Summary
The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. [provided by RefSeq, Apr 2016]
Expression
Biased expression in lymph node (RPKM 13.0), appendix (RPKM 8.0) and 9 other tissues See more
Orthologs

Genomic context

See P2RY10 in Genome Data Viewer
Location:
Xq21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (78945332..78963727)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (78200829..78219224)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 54 Neighboring gene microRNA 4328 Neighboring gene P2Y receptor family member 10B, pseudogene Neighboring gene G protein-coupled receptor 174

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
putative P2Y purinoceptor 10
Names
G-protein coupled purinergic receptor P2Y10
P2Y-like receptor
purinergic receptor P2Y, G-protein coupled, 10
purinergic receptor P2Y10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013276.2 RefSeqGene

    Range
    5001..23396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324218.2NP_001311147.1  putative P2Y purinoceptor 10 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR compared to variant 1.
    Source sequence(s)
    BX104083, DB213380, Z82200
    Consensus CDS
    CCDS14442.1
    UniProtKB/Swiss-Prot
    O00398
    Conserved Domains (1) summary
    cd15153
    Location:35316
    7tmA_P2Y10; P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001324221.2NP_001311150.1  putative P2Y purinoceptor 10 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region and initiates translation at an upstream alternate start codon compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a.
    Source sequence(s)
    BX104083, DB131258, Z82200
    Conserved Domains (1) summary
    pfam00001
    Location:69322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001324225.2NP_001311154.1  putative P2Y purinoceptor 10 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an exon and lacks an exon in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a longer N-terminus than isoform a.
    Source sequence(s)
    BX104083, DA817144, Z82200
  4. NM_014499.4NP_055314.1  putative P2Y purinoceptor 10 isoform a

    See identical proteins and their annotated locations for NP_055314.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AW294346, BC051875, BX104083, Z82200
    Consensus CDS
    CCDS14442.1
    UniProtKB/Swiss-Prot
    O00398
    Related
    ENSP00000171757.2, ENST00000171757.3
    Conserved Domains (1) summary
    cd15153
    Location:35316
    7tmA_P2Y10; P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_198333.2NP_938147.1  putative P2Y purinoceptor 10 isoform a

    See identical proteins and their annotated locations for NP_938147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the 5' UTR compared to variant 1.
    Source sequence(s)
    AW294346, BC051875, BX104083, CD639881, Z82200
    Consensus CDS
    CCDS14442.1
    UniProtKB/Swiss-Prot
    O00398
    Related
    ENSP00000443138.1, ENST00000544091.1
    Conserved Domains (1) summary
    cd15153
    Location:35316
    7tmA_P2Y10; P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    78945332..78963727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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