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GOLIM4 golgi integral membrane protein 4 [ Homo sapiens (human) ]

Gene ID: 27333, updated on 23-Nov-2021

Summary

Official Symbol
GOLIM4provided by HGNC
Official Full Name
golgi integral membrane protein 4provided by HGNC
Primary source
HGNC:HGNC:15448
See related
Ensembl:ENSG00000173905 MIM:606805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P138; GIMPC; GOLPH4; GPP130
Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 37.0), colon (RPKM 33.7) and 24 other tissues See more
Orthologs
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Genomic context

See GOLIM4 in Genome Data Viewer
Location:
3q26.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (168008672..168095924, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (167726477..167813712, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic pseudogene Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 26 Neighboring gene uncharacterized LOC107986152 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4789 Neighboring gene Sharpr-MPRA regulatory region 6960

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.
GeneReviews: Not available
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
GeneReviews: Not available
Many sequence variants affecting diversity of adult human height.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi lumen TAS
Traceable Author Statement
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cis-Golgi network TAS
Traceable Author Statement
more info
PubMed 
located_in endocytic vesicle TAS
Traceable Author Statement
more info
PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
Golgi integral membrane protein 4
Names
130 kDa golgi-localized phosphoprotein
cis Golgi-localized calcium-binding protein
golgi integral membrane protein, cis
golgi phosphoprotein 4
golgi phosphoprotein of 130 kDa
golgi-localized phosphoprotein of 130 kDa
type II Golgi membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308155.2NP_001295084.1  Golgi integral membrane protein 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC117467, BC171748, BM925724, BX097666, DA028346, DA542956
    Consensus CDS
    CCDS77854.1
    UniProtKB/TrEMBL
    F8W785
    Related
    ENSP00000309893.4, ENST00000309027.4
    Conserved Domains (1) summary
    pfam09798
    Location:120251
    LCD1; DNA damage checkpoint protein
  2. NM_014498.5NP_055313.1  Golgi integral membrane protein 4 isoform 1

    See identical proteins and their annotated locations for NP_055313.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117467, AK307557, AU310391, BC143232, BM925724, BX097666, U55853
    Consensus CDS
    CCDS3204.1
    UniProtKB/Swiss-Prot
    O00461
    Related
    ENSP00000417354.1, ENST00000470487.6
    Conserved Domains (1) summary
    cl23765
    Location:67213
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    168008672..168095924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247365.3XP_005247422.1  Golgi integral membrane protein 4 isoform X2

    Conserved Domains (1) summary
    pfam09798
    Location:120251
    LCD1; DNA damage checkpoint protein
  2. XM_005247364.3XP_005247421.1  Golgi integral membrane protein 4 isoform X1

    Conserved Domains (1) summary
    cl23765
    Location:67213
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  3. XM_017006183.1XP_016861672.1  Golgi integral membrane protein 4 isoform X3

    Conserved Domains (2) summary
    PTZ00121
    Location:2450
    PTZ00121; MAEBL; Provisional
    TIGR00927
    Location:310508
    2A1904; K+-dependent Na+/Ca+ exchanger
  4. XM_024453455.1XP_024309223.1  Golgi integral membrane protein 4 isoform X4

    Conserved Domains (3) summary
    pfam09798
    Location:1132
    LCD1; DNA damage checkpoint protein
    cl26761
    Location:320510
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl27511
    Location:197440
    Na_Ca_ex; Sodium/calcium exchanger protein
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