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GOLIM4 golgi integral membrane protein 4 [ Homo sapiens (human) ]

Gene ID: 27333, updated on 17-Jun-2019

Summary

Official Symbol
GOLIM4provided by HGNC
Official Full Name
golgi integral membrane protein 4provided by HGNC
Primary source
HGNC:HGNC:15448
See related
Ensembl:ENSG00000173905 MIM:606805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P138; GIMPC; GOLPH4; GPP130
Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 37.0), colon (RPKM 33.7) and 24 other tissues See more
Orthologs

Genomic context

See GOLIM4 in Genome Data Viewer
Location:
3q26.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (168008672..168095924, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (167726457..167813712, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic pseudogene Neighboring gene uncharacterized LOC107986152 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 26 Neighboring gene EGF like and EMI domain containing 1, pseudogene Neighboring gene RNA, U2 small nuclear 20, pseudogene Neighboring gene microRNA 551b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

Pathways from BioSystems

  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Intra-Golgi traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi traffic, organism-specific biosystemThe mammalian Golgi consists of at least three biochemically distinct cisternae, cis-, medial- and trans (reviewed in Szul and Sztul, 2011; Day et al, 2013). The structure and function of the Golgi a...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi lumen TAS
Traceable Author Statement
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
cis-Golgi network TAS
Traceable Author Statement
more info
PubMed 
endocytic vesicle TAS
Traceable Author Statement
more info
PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
Golgi integral membrane protein 4
Names
130 kDa golgi-localized phosphoprotein
cis Golgi-localized calcium-binding protein
golgi integral membrane protein, cis
golgi phosphoprotein 4
golgi phosphoprotein of 130 kDa
golgi-localized phosphoprotein of 130 kDa
type II Golgi membrane protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308155.2NP_001295084.1  Golgi integral membrane protein 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC117467, BC171748, BM925724, BX097666, DA028346, DA542956
    Consensus CDS
    CCDS77854.1
    UniProtKB/TrEMBL
    F8W785
    Related
    ENSP00000309893.4, ENST00000309027.4
    Conserved Domains (1) summary
    pfam09798
    Location:120251
    LCD1; DNA damage checkpoint protein
  2. NM_014498.5NP_055313.1  Golgi integral membrane protein 4 isoform 1

    See identical proteins and their annotated locations for NP_055313.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117467, AK307557, AU310391, BC143232, BM925724, BX097666, U55853
    Consensus CDS
    CCDS3204.1
    UniProtKB/Swiss-Prot
    O00461
    Related
    ENSP00000417354.1, ENST00000470487.5
    Conserved Domains (1) summary
    cl23765
    Location:67213
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    168008672..168095924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247365.3XP_005247422.1  Golgi integral membrane protein 4 isoform X2

    Conserved Domains (1) summary
    pfam09798
    Location:120251
    LCD1; DNA damage checkpoint protein
  2. XM_005247364.3XP_005247421.1  Golgi integral membrane protein 4 isoform X1

    Conserved Domains (1) summary
    cl23765
    Location:67213
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  3. XM_017006183.1XP_016861672.1  Golgi integral membrane protein 4 isoform X3

  4. XM_024453455.1XP_024309223.1  Golgi integral membrane protein 4 isoform X4

    Conserved Domains (3) summary
    pfam09798
    Location:1132
    LCD1; DNA damage checkpoint protein
    cl26761
    Location:320510
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl27511
    Location:197440
    Na_Ca_ex; Sodium/calcium exchanger protein
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