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PGAP2 post-GPI attachment to proteins 2 [ Homo sapiens (human) ]

Gene ID: 27315, updated on 8-Apr-2026
Official Symbol
PGAP2provided by HGNC
Official Full Name
post-GPI attachment to proteins 2provided by HGNC
Primary source
HGNC:HGNC:17893
See related
Ensembl:ENSG00000148985 MIM:615187; AllianceGenome:HGNC:17893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRAG1; MRT17; MRT21; HPMRS3; CWH43-N
Summary
The protein encoded by this gene plays a role in the maturation of glycosylphosphatidylinositol (GPI) anchors on GPI-anchored proteins. Mutations in this gene are associated with an autosomal recessive syndrome characterized by hyperphosphatasia and intellectual disability. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in skin (RPKM 10.4), testis (RPKM 5.4) and 25 other tissues See more
Orthologs
Try the new Gene page
Try the new Transcripts and proteins table
See PGAP2 in Genome Data Viewer
Location:
11p15.4
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3797720..3826371)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3863057..3891698)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3818954..3847601)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene RNA, U6 small nuclear 1143, pseudogene Neighboring gene nucleoporin 98kDa recombination region Neighboring gene MPRA-validated peak1178 silencer Neighboring gene MPRA-validated peak1179 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3811721-3812640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3812641-3813558 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3083 Neighboring gene RNA, U7 small nuclear 50 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3084 Neighboring gene uncharacterized LOC124902618 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:3841189-3841380 Neighboring gene uncharacterized LOC124902619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4310 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4311 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3876149-3877094 Neighboring gene STIM1 antisense RNA 1 Neighboring gene ras homolog family member G Neighboring gene stromal interaction molecule 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of post-GPI attachment to proteins 2 (PGAP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC799, FLJ26520

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
acyltransferase PGAP2
Names
FGF receptor activating protein 1
cell wall biogenesis 43 N-terminal homolog
post-GPI attachment to proteins factor 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051812.1 RefSeqGene

    Range
    5001..33648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145438.3NP_001138910.2  acyltransferase PGAP2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090587
    Consensus CDS
    CCDS44523.1
    UniProtKB/TrEMBL
    A0A0S2Z568, E9PQ19
    Related
    ENSP00000300730.6, ENST00000300730.10
  2. NM_001256235.2NP_001243164.1  acyltransferase PGAP2 isoform 3

    See identical proteins and their annotated locations for NP_001243164.1

    Status: REVIEWED

    Source sequence(s)
    AC090587
    Consensus CDS
    CCDS73245.1
    UniProtKB/TrEMBL
    A0A0A0MS75
    Related
    ENSP00000380188.3, ENST00000396991.6
    Conserved Domains (1) summary
    pfam10277
    Location:75259
    Frag1; Frag1/DRAM/Sfk1 family
  3. NM_001256236.2NP_001243165.2  acyltransferase PGAP2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC090587
    UniProtKB/TrEMBL
    A8MYS5
    Related
    ENSP00000434631.2, ENST00000464906.6
  4. NM_001256237.2NP_001243166.2  acyltransferase PGAP2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC090587
    UniProtKB/TrEMBL
    H0YDJ5, H0YDQ4
    Related
    ENSP00000434088.2, ENST00000464261.5
  5. NM_001256238.2NP_001243167.1  acyltransferase PGAP2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090587
    Consensus CDS
    CCDS58113.1
    UniProtKB/TrEMBL
    H0YDJ5
    Related
    ENSP00000431851.1, ENST00000493547.6
    Conserved Domains (1) summary
    pfam10277
    Location:18178
    Frag1; Frag1/DRAM/Sfk1 family
  6. NM_001256239.2NP_001243168.1  acyltransferase PGAP2 isoform 7

    See identical proteins and their annotated locations for NP_001243168.1

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, BI911028, BX340489, CB988453
    UniProtKB/TrEMBL
    A0A0S2Z568, E9PQ19
    Related
    ENSP00000434507.1, ENST00000469307.4
    Conserved Domains (1) summary
    pfam10277
    Location:18237
    Frag1; Frag1/DRAM/Sfk1 family
  7. NM_001256240.2NP_001243169.1  acyltransferase PGAP2 isoform 8

    See identical proteins and their annotated locations for NP_001243169.1

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, BI768071, CB988453
    Consensus CDS
    CCDS58112.1
    UniProtKB/Swiss-Prot
    E9PJG5, H7BXL9, Q6UC77, Q96G66, Q9UF01, Q9UHJ9, Q9Y4N1
    UniProtKB/TrEMBL
    A0A024RCD5, E9PQ19
    Related
    ENSP00000435223.1, ENST00000463452.6
    Conserved Domains (1) summary
    pfam10277
    Location:18241
    Frag1; Frag1/DRAM/Sfk1 family
  8. NM_001283038.2NP_001269967.2  acyltransferase PGAP2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090587
    Consensus CDS
    CCDS73244.1
    UniProtKB/Swiss-Prot
    E9PJG5, H7BXL9, Q6UC77, Q96G66, Q9UF01, Q9UHJ9, Q9Y4N1
    UniProtKB/TrEMBL
    A0A024RCD5, E9PQ19
    Related
    ENSP00000534305.1, ENST00000864246.1
  9. NM_001283039.2NP_001269968.2  acyltransferase PGAP2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC090587
    UniProtKB/TrEMBL
    H0YDC6
    Related
    ENSP00000433377.2, ENST00000532523.5
  10. NM_001283040.1NP_001269969.1  acyltransferase PGAP2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC090587, AF159615, AL096753, DA287291, HY171112
    UniProtKB/Swiss-Prot
    Q9UHJ9
  11. NM_001346397.2NP_001333326.1  acyltransferase PGAP2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC090587
    UniProtKB/TrEMBL
    E9PQ19
  12. NM_001346398.2NP_001333327.1  acyltransferase PGAP2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090587
    Consensus CDS
    CCDS58112.1
    UniProtKB/Swiss-Prot
    E9PJG5, H7BXL9, Q6UC77, Q96G66, Q9UF01, Q9UHJ9, Q9Y4N1
    UniProtKB/TrEMBL
    A0A024RCD5, E9PQ19
    Related
    ENSP00000623503.1, ENST00000953444.1
    Conserved Domains (1) summary
    pfam10277
    Location:18241
    Frag1; Frag1/DRAM/Sfk1 family
  13. NM_001346399.2NP_001333328.1  acyltransferase PGAP2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC090587
    Consensus CDS
    CCDS86172.1
    UniProtKB/TrEMBL
    B7Z2X5
  14. NM_001346400.2NP_001333329.1  acyltransferase PGAP2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090587
    UniProtKB/TrEMBL
    A0A0S2Z568, E9PQ19
    Conserved Domains (1) summary
    pfam10277
    Location:18237
    Frag1; Frag1/DRAM/Sfk1 family
  15. NM_001346401.2NP_001333330.1  acyltransferase PGAP2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC090587
  16. NM_001346402.2NP_001333331.1  acyltransferase PGAP2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC090587
  17. NM_001346403.1NP_001333332.1  acyltransferase PGAP2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC090587
  18. NM_001346404.1NP_001333333.1  acyltransferase PGAP2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC090587
    Consensus CDS
    CCDS86171.1
    UniProtKB/TrEMBL
    H0YDJ5, H0YDQ4
  19. NM_001346405.1NP_001333334.1  acyltransferase PGAP2 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 12 and 24, encodes isoform 8.
    Source sequence(s)
    AC090587
    Consensus CDS
    CCDS58112.1
    UniProtKB/Swiss-Prot
    E9PJG5, H7BXL9, Q6UC77, Q96G66, Q9UF01, Q9UHJ9, Q9Y4N1
    UniProtKB/TrEMBL
    A0A024RCD5, E9PQ19
    Related
    ENSP00000534308.1, ENST00000864249.1
    Conserved Domains (1) summary
    pfam10277
    Location:18241
    Frag1; Frag1/DRAM/Sfk1 family
  20. NM_014489.4NP_055304.1  acyltransferase PGAP2 isoform 1

    See identical proteins and their annotated locations for NP_055304.1

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753
    Consensus CDS
    CCDS7747.1
    UniProtKB/TrEMBL
    A8MYS5
    Related
    ENSP00000278243.4, ENST00000278243.9
    Conserved Domains (1) summary
    pfam10277
    Location:79302
    Frag1; Frag1/DRAM/Sfk1 family

RNA

  1. NR_027016.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, CB988453, CX872317
    Related
    ENST00000496834.6
  2. NR_027017.4 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090587
  3. NR_027018.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AK295202, AL096753
  4. NR_045923.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AK307359, AL096753, DA287291
    Related
    ENST00000396993.8
  5. NR_045925.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, BG468212, DA287291
    Related
    ENST00000864247.1
  6. NR_045926.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, AL558360, DA287291
    Related
    ENST00000477358.6
  7. NR_045927.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, BG707484, DA287291
  8. NR_045929.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, BI759334, CB988453
  9. NR_104270.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, CD675113, DA287291
  10. NR_104271.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, BI858175, BI911526, DA287291
    Related
    ENST00000528216.5
  11. NR_104272.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF159615, AL096753, CB988453
  12. NR_144427.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090587
  13. NR_144428.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090587
  14. NR_144429.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090587
  15. NR_144430.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090587

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    3797720..3826371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519992.2XP_011518294.1  acyltransferase PGAP2 isoform X3

    Conserved Domains (1) summary
    pfam10277
    Location:174358
    Frag1; Frag1/DRAM/Sfk1 family
  2. XM_047426778.1XP_047282734.1  acyltransferase PGAP2 isoform X6

  3. XM_011519996.2XP_011518298.1  acyltransferase PGAP2 isoform X8

    Conserved Domains (1) summary
    pfam10277
    Location:158342
    Frag1; Frag1/DRAM/Sfk1 family
  4. XM_047426777.1XP_047282733.1  acyltransferase PGAP2 isoform X5

    UniProtKB/TrEMBL
    A8MYS5
  5. XM_047426780.1XP_047282736.1  acyltransferase PGAP2 isoform X10

  6. XM_047426786.1XP_047282742.1  acyltransferase PGAP2 isoform X19

    UniProtKB/TrEMBL
    E9PQ19
  7. XM_006718185.3XP_006718248.1  acyltransferase PGAP2 isoform X14

    UniProtKB/TrEMBL
    A8MYS5
    Conserved Domains (1) summary
    pfam10277
    Location:84268
    Frag1; Frag1/DRAM/Sfk1 family
  8. XM_047426782.1XP_047282738.1  acyltransferase PGAP2 isoform X15

    UniProtKB/TrEMBL
    A8MYS5
  9. XM_047426784.1XP_047282740.1  acyltransferase PGAP2 isoform X17

  10. XM_047426785.1XP_047282741.1  acyltransferase PGAP2 isoform X18

  11. XM_047426789.1XP_047282745.1  acyltransferase PGAP2 isoform X21

    UniProtKB/TrEMBL
    B7Z2X5
    Related
    ENSP00000434401.1, ENST00000465307.6
  12. XM_047426792.1XP_047282748.1  acyltransferase PGAP2 isoform X22

  13. XM_011519998.3XP_011518300.1  acyltransferase PGAP2 isoform X9

    See identical proteins and their annotated locations for XP_011518300.1

    Conserved Domains (1) summary
    pfam10277
    Location:152336
    Frag1; Frag1/DRAM/Sfk1 family
  14. XM_011520004.3XP_011518306.2  acyltransferase PGAP2 isoform X13

  15. XM_047426788.1XP_047282744.1  acyltransferase PGAP2 isoform X20

  16. XM_047426793.1XP_047282749.1  acyltransferase PGAP2 isoform X23

  17. XM_011519999.2XP_011518301.1  acyltransferase PGAP2 isoform X9

    See identical proteins and their annotated locations for XP_011518301.1

    Conserved Domains (1) summary
    pfam10277
    Location:152336
    Frag1; Frag1/DRAM/Sfk1 family
  18. XM_011519990.3XP_011518292.3  acyltransferase PGAP2 isoform X1

    UniProtKB/TrEMBL
    A8MYS5
  19. XM_011519991.3XP_011518293.3  acyltransferase PGAP2 isoform X2

    UniProtKB/TrEMBL
    A8MYS5
  20. XM_024448444.2XP_024304212.1  acyltransferase PGAP2 isoform X16

    Conserved Domains (1) summary
    pfam10277
    Location:75255
    Frag1; Frag1/DRAM/Sfk1 family
  21. XM_011520002.2XP_011518304.1  acyltransferase PGAP2 isoform X11

    See identical proteins and their annotated locations for XP_011518304.1

    UniProtKB/TrEMBL
    A0A0S2Z568, E9PQ19
    Conserved Domains (1) summary
    pfam10277
    Location:18237
    Frag1; Frag1/DRAM/Sfk1 family
  22. XM_047426779.1XP_047282735.1  acyltransferase PGAP2 isoform X7

  23. XM_047426787.1XP_047282743.1  acyltransferase PGAP2 isoform X19

    UniProtKB/TrEMBL
    E9PQ19
  24. XM_047426776.1XP_047282732.1  acyltransferase PGAP2 isoform X4

  25. XM_047426781.1XP_047282737.1  acyltransferase PGAP2 isoform X2

    UniProtKB/TrEMBL
    A8MYS5
  26. XM_024448443.2XP_024304211.1  acyltransferase PGAP2 isoform X16

    Conserved Domains (1) summary
    pfam10277
    Location:75255
    Frag1; Frag1/DRAM/Sfk1 family
  27. XM_047426790.1XP_047282746.1  acyltransferase PGAP2 isoform X21

    UniProtKB/TrEMBL
    B7Z2X5
  28. XM_006718181.4XP_006718244.1  acyltransferase PGAP2 isoform X12

    Conserved Domains (1) summary
    pfam10277
    Location:80303
    Frag1; Frag1/DRAM/Sfk1 family
  29. XM_047426783.1XP_047282739.1  acyltransferase PGAP2 isoform X7

  30. XM_047426791.1XP_047282747.1  acyltransferase PGAP2 isoform X21

    UniProtKB/TrEMBL
    B7Z2X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    3863057..3891698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368437.1XP_054224412.1  acyltransferase PGAP2 isoform X3

  2. XM_054368440.1XP_054224415.1  acyltransferase PGAP2 isoform X6

  3. XM_054368442.1XP_054224417.1  acyltransferase PGAP2 isoform X8

  4. XM_054368439.1XP_054224414.1  acyltransferase PGAP2 isoform X5

    UniProtKB/TrEMBL
    A8MYS5
  5. XM_054368445.1XP_054224420.1  acyltransferase PGAP2 isoform X10

  6. XM_054368456.1XP_054224431.1  acyltransferase PGAP2 isoform X19

    UniProtKB/TrEMBL
    E9PQ19
  7. XM_054368450.1XP_054224425.1  acyltransferase PGAP2 isoform X14

    UniProtKB/TrEMBL
    A8MYS5
  8. XM_054368451.1XP_054224426.1  acyltransferase PGAP2 isoform X15

    UniProtKB/TrEMBL
    A8MYS5
  9. XM_054368454.1XP_054224429.1  acyltransferase PGAP2 isoform X17

  10. XM_054368455.1XP_054224430.1  acyltransferase PGAP2 isoform X18

  11. XM_054368459.1XP_054224434.1  acyltransferase PGAP2 isoform X21

    UniProtKB/TrEMBL
    B7Z2X5
  12. XM_054368461.1XP_054224436.1  acyltransferase PGAP2 isoform X22

  13. XM_054368443.1XP_054224418.1  acyltransferase PGAP2 isoform X9

  14. XM_054368448.1XP_054224423.1  acyltransferase PGAP2 isoform X13

  15. XM_054368458.1XP_054224433.1  acyltransferase PGAP2 isoform X20

  16. XM_054368462.1XP_054224437.1  acyltransferase PGAP2 isoform X23

  17. XM_054368444.1XP_054224419.1  acyltransferase PGAP2 isoform X9

  18. XM_054368435.1XP_054224410.1  acyltransferase PGAP2 isoform X1

    UniProtKB/TrEMBL
    A8MYS5
  19. XM_054368436.1XP_054224411.1  acyltransferase PGAP2 isoform X2

    UniProtKB/TrEMBL
    A8MYS5
  20. XM_054368453.1XP_054224428.1  acyltransferase PGAP2 isoform X16

  21. XM_054368446.1XP_054224421.1  acyltransferase PGAP2 isoform X11

    UniProtKB/TrEMBL
    A0A0S2Z568, E9PQ19
  22. XM_054368441.1XP_054224416.1  acyltransferase PGAP2 isoform X7

  23. XM_054368457.1XP_054224432.1  acyltransferase PGAP2 isoform X19

    UniProtKB/TrEMBL
    E9PQ19
  24. XM_054368438.1XP_054224413.1  acyltransferase PGAP2 isoform X4

  25. XM_054368449.1XP_054224424.1  acyltransferase PGAP2 isoform X2

    UniProtKB/TrEMBL
    A8MYS5
  26. XM_054368452.1XP_054224427.1  acyltransferase PGAP2 isoform X16

  27. XM_054368460.1XP_054224435.1  acyltransferase PGAP2 isoform X21

    UniProtKB/TrEMBL
    B7Z2X5
  28. XM_054368447.1XP_054224422.1  acyltransferase PGAP2 isoform X12