U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DHDH dihydrodiol dehydrogenase [ Homo sapiens (human) ]

Gene ID: 27294, updated on 10-Dec-2024

Summary

Official Symbol
DHDHprovided by HGNC
Official Full Name
dihydrodiol dehydrogenaseprovided by HGNC
Primary source
HGNC:HGNC:17887
See related
Ensembl:ENSG00000104808 MIM:606377; AllianceGenome:HGNC:17887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2DD; HUM2DD
Summary
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 7.4), small intestine (RPKM 4.3) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DHDH in Genome Data Viewer
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48932795..48944969)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51927659..51939831)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49436956..49448226)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49390815-49391709 Neighboring gene TUB like protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49398133-49398948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10906 Neighboring gene CRISPRi-FlowFISH-validated BAX and NUCB1 regulatory element Neighboring gene nucleobindin 1 Neighboring gene NUCB1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49422347-49422846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49425993-49426492 Neighboring gene Sharpr-MPRA regulatory region 4424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49436529-49437030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49438311-49438870 Neighboring gene Sharpr-MPRA regulatory region 12688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49457811-49458379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49458380-49458947 Neighboring gene CRISPRi-FlowFISH-validated FTL regulatory element 2 Neighboring gene CRISPRi-FlowFISH-validated FTL regulatory element 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14919 Neighboring gene BCL2 associated X, apoptosis regulator Neighboring gene ferritin light chain

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Names
3-deoxyglucosone reductase
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase
dihydrodiol dehydrogenase (dimeric)
NP_055290.1
XP_005258805.1
XP_016882087.1
XP_047294573.1
XP_054176551.1
XP_054176552.1
XP_054176553.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046910.1 RefSeqGene

    Range
    5061..16331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014475.4NP_055290.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

    See identical proteins and their annotated locations for NP_055290.1

    Status: REVIEWED

    Source sequence(s)
    BC032730, BF510979
    Consensus CDS
    CCDS12741.1
    UniProtKB/Swiss-Prot
    Q9UQ10
    Related
    ENSP00000221403.2, ENST00000221403.7
    Conserved Domains (1) summary
    COG0673
    Location:1326
    MviM; Predicted dehydrogenase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48932795..48944969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026598.2XP_016882087.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X2

  2. XM_005258748.5XP_005258805.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X3

    Conserved Domains (1) summary
    COG0673
    Location:13214
    MviM; Predicted dehydrogenase [General function prediction only]
  3. XM_047438617.1XP_047294573.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X1

    UniProtKB/TrEMBL
    E5RGT8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51927659..51939831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320577.1XP_054176552.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X2

  2. XM_054320578.1XP_054176553.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X3

  3. XM_054320576.1XP_054176551.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X1

    UniProtKB/TrEMBL
    E5RGT8