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DHDH dihydrodiol dehydrogenase [ Homo sapiens (human) ]

Gene ID: 27294, updated on 18-Aug-2020

Summary

Official Symbol
DHDHprovided by HGNC
Official Full Name
dihydrodiol dehydrogenaseprovided by HGNC
Primary source
HGNC:HGNC:17887
See related
Ensembl:ENSG00000104808 MIM:606377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2DD; HUM2DD
Summary
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 7.4), small intestine (RPKM 4.3) and 5 other tissues See more
Orthologs

Genomic context

See DHDH in Genome Data Viewer
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48932790..48944969)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49436939..49448226)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene TUB like protein 2 Neighboring gene nucleobindin 1 Neighboring gene NUCB1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12688 Neighboring gene BCL2 associated X, apoptosis regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-xylose 1-dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD(P)+ transhydrogenase activity TAS
Traceable Author Statement
more info
PubMed 
electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
D-xylose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Names
3-deoxyglucosone reductase
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase
dihydrodiol dehydrogenase (dimeric)
NP_055290.1
XP_005258805.1
XP_016882087.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046910.1 RefSeqGene

    Range
    5061..16331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014475.4NP_055290.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

    See identical proteins and their annotated locations for NP_055290.1

    Status: REVIEWED

    Source sequence(s)
    BC032730, BF510979
    Consensus CDS
    CCDS12741.1
    UniProtKB/Swiss-Prot
    Q9UQ10
    Related
    ENSP00000221403.2, ENST00000221403.7
    Conserved Domains (1) summary
    COG0673
    Location:1326
    MviM; Predicted dehydrogenase [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48932790..48944969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258748.4XP_005258805.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X2

    Conserved Domains (1) summary
    COG0673
    Location:13214
    MviM; Predicted dehydrogenase [General function prediction only]
  2. XM_017026598.1XP_016882087.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X1

RNA

  1. XR_935796.3 RNA Sequence

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