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DIMT1 DIM1 rRNA methyltransferase and ribosome maturation factor [ Homo sapiens (human) ]

Gene ID: 27292, updated on 5-May-2024

Summary

Official Symbol
DIMT1provided by HGNC
Official Full Name
DIM1 rRNA methyltransferase and ribosome maturation factorprovided by HGNC
Primary source
HGNC:HGNC:30217
See related
Ensembl:ENSG00000086189 MIM:612499; AllianceGenome:HGNC:30217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIM1; DIMT1L; HUSSY5; HSA9761
Summary
The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in urinary bladder (RPKM 12.5), lymph node (RPKM 11.7) and 25 other tissues See more
Orthologs
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Genomic context

Location:
5q12.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (62387254..62403905, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (63206803..63223500, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61683081..61699732, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61457226-61457726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61457727-61458227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61458278-61458778 Neighboring gene RN7SK pseudogene 157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61532143-61532644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61532645-61533144 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1488 Neighboring gene Sharpr-MPRA regulatory region 4645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61610189-61610690 Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene kinesin family member 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16052 Neighboring gene importin 11 Neighboring gene RNA, U6 small nuclear 661, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr5:61791875-61792070 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of DIM1 dimethyladenosine transferase 1 homolog (DIMT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in rRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA methylation TAS
Traceable Author Statement
more info
 
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable dimethyladenosine transferase
Names
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
18S rRNA dimethylase
DIM1 dimethyladenosine transferase 1 homolog
DIM1 dimethyladenosine transferase 1-like
DIMT1 rRNA methyltransferase and ribosome maturation factor
S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
dimethyladenosine transferase
probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
probable 18S rRNA dimethylase
probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
NP_001335005.1
NP_001335006.1
NP_055288.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348076.2NP_001335005.1  probable dimethyladenosine transferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC016637, BC002841, DC398380
    Consensus CDS
    CCDS87298.1
    UniProtKB/TrEMBL
    A0A0C4DGB1, B4DRY2
    Related
    ENSP00000421754.1, ENST00000506390.5
    Conserved Domains (1) summary
    cl17173
    Location:24263
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001348077.2NP_001335006.1  probable dimethyladenosine transferase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC016637
    Conserved Domains (1) summary
    cl17173
    Location:1159
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_014473.4NP_055288.1  probable dimethyladenosine transferase isoform 1

    See identical proteins and their annotated locations for NP_055288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC016637, AK292723, BQ009563
    Consensus CDS
    CCDS3981.1
    UniProtKB/Swiss-Prot
    O76025, Q9BU77, Q9UES1, Q9UNQ2
    UniProtKB/TrEMBL
    A8K9K8
    Related
    ENSP00000199320.4, ENST00000199320.9
    Conserved Domains (1) summary
    PTZ00338
    Location:24312
    PTZ00338; dimethyladenosine transferase-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    62387254..62403905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    63206803..63223500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)