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RBMXL2 RBMX like 2 [ Homo sapiens (human) ]

Gene ID: 27288, updated on 4-Nov-2018

Summary

Official Symbol
RBMXL2provided by HGNC
Official Full Name
RBMX like 2provided by HGNC
Primary source
HGNC:HGNC:17886
See related
Ensembl:ENSG00000170748 MIM:605444; Vega:OTTHUMG00000165509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPGT; HNRNPGT; HNRNPG-T
Summary
This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See RBMXL2 in Genome Data Viewer
Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (7088934..7091148)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (7110165..7112379)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724711 Neighboring gene zinc finger protein 215 Neighboring gene zinc finger protein 214 Neighboring gene NLR family pyrin domain containing 14 Neighboring gene microRNA 302e Neighboring gene synaptotagmin 9 Neighboring gene uncharacterized LOC100506258

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
commitment complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding motif protein, X-linked-like-2
Names
RNA binding motif protein, X-linked like 2
heterogeneous nuclear ribonucleoprotein G T
hnRNP G-T
testes-specific heterogenous nuclear ribonucleoprotein G-T
testis-specific heterogeneous nuclear ribonucleoprotein G-T

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014469.4NP_055284.3  RNA-binding motif protein, X-linked-like-2

    See identical proteins and their annotated locations for NP_055284.3

    Status: REVIEWED

    Source sequence(s)
    AC100875
    Consensus CDS
    CCDS7777.1
    UniProtKB/Swiss-Prot
    O75526
    Related
    ENSP00000304139.5, OTTHUMP00000230008, ENST00000306904.6, OTTHUMT00000384552
    Conserved Domains (3) summary
    COG0724
    Location:981
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:786
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:173217
    RBM1CTR; RBM1CTR (NUC064) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    7088934..7091148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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