VENTX VENT homeobox [Homo sapiens (human)] - Gene

Summary

Official Symbol: VENTXprovided by HGNC
Official Full Name: VENT homeoboxprovided by HGNC
Primary source: HGNC:HGNC:13639
See related: Ensembl:ENSG00000151650 MIM:607158
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NA88A; HPX42B; VENTX2
Summary: This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]
Expression: Broad expression in appendix (RPKM 1.9), spleen (RPKM 1.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109.20211119	current	GRCh38.p13 (GCF_000001405.39)	10	NC_000010.11 (133237855..133241928)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (135051359..135055432)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VentX expression in tumor-associated macrophages promotes phagocytosis and immunity against pancreatic cancers.
Title: VentX expression in tumor-associated macrophages promotes phagocytosis and immunity against pancreatic cancers.
Findings suggest potential applications of homeobox protein VentX (VentX)-regulated tumor-associated macrophages (TAMs) in cancer immunotherapy.
Title: The homeobox protein VentX reverts immune suppression in the tumor microenvironment.
VENTX impairs expression of genes involved in erythroid differentiation and is highly expressed in patients with acute erythroid leukemia.
Title: VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice.
VentX induces apoptosis of cancer cells in a p53-independent manner
Title: Homeobox protein VentX induces p53-independent apoptosis in cancer cells.
Data suggest that homeobox transcription factor VentX may be a target to modulate Dendritic cells (DCs) functions and manage inflammatory diseases.
Title: Homeobox transcription factor VentX regulates differentiation and maturation of human dendritic cells.
VentX regulates critical cell cycle regulators and Wnt downstream genes previously implicated in HSC/MPP proliferation and expansion.
Title: Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.
Results provide mechanistic insight into the crucial roles of VentX in macrophage differentiation and proinflammatory activation and suggest that dysregulation of VentX may play a role in the pathogenesis of autoimmune diseases.
Title: The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation.
Data show that VentX is a direct transcriptional activator of p53-p21 and p16ink4a-Rb tumor suppression pathways.
Title: VentX trans-activates p53 and p16ink4a to regulate cellular senescence.
these data extend our insights into the function of embryonic mesodermal factors in human postnatal hematopoiesis and indicate a role for VENTX in normal and malignant myelopoiesis.
Title: The vent-like homeobox gene VENTX promotes human myeloid differentiation and is highly expressed in acute myeloid leukemia.
a potential role of VentX in the clinical behavior of hematopoietic malignancies.
Title: VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S1423 (e-PCR)
- UniSTS:149619

NoName (e-PCR)
- UniSTS:482694

VENTX2_2047 (e-PCR)
- UniSTS:281075

Homology

Homologs of the VENTX gene: The VENTX gene is conserved in chimpanzee, Rhesus monkey, and dog.
Orthologs from Annotation Pipeline: 159 organisms have orthologs with human gene VENTX
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: homeobox protein VENTX

Names: VENT homeobox homolog; VENT-like homeobox 2; VENT-like homeobox protein 2; hemopoietic progenitor homeobox protein VENTX2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.