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VENTX VENT homeobox [ Homo sapiens (human) ]

Gene ID: 27287, updated on 5-Jul-2025
Official Symbol
VENTXprovided by HGNC
Official Full Name
VENT homeoboxprovided by HGNC
Primary source
HGNC:HGNC:13639
See related
Ensembl:ENSG00000151650 MIM:607158; AllianceGenome:HGNC:13639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NA88A; HPX42B; VENTX2
Summary
This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 1.9), spleen (RPKM 1.1) and 24 other tissues See more
Orthologs
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See VENTX in Genome Data Viewer
Location:
10q26.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133237855..133241928)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134193345..134197419)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135051359..135055432)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene kinase non-catalytic C-lobe domain containing 1 Neighboring gene uncharacterized LOC105378573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135013107-135013853 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135013854-135014599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135038599-135039222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:135043703-135044502 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135045303-135046102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135048520-135049124 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135050334-135050937 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135050938-135051542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135051543-135052146 Neighboring gene undifferentiated embryonic cell transcription factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135056640-135057492 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:135057814-135059013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135060766-135061280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135061797-135062311 Neighboring gene MIR202 host gene Neighboring gene microRNA 202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2971 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135075828-135076804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135084013-135084769 Neighboring gene ADAM metallopeptidase domain 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135087865-135088514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135089815-135090462

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC119910, MGC119911

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
homeobox protein VENTX
Names
VENT homeobox homolog
VENT-like homeobox 2
VENT-like homeobox protein 2
hemopoietic progenitor homeobox protein VENTX2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014468.4NP_055283.1  homeobox protein VENTX

    See identical proteins and their annotated locations for NP_055283.1

    Status: REVIEWED

    Source sequence(s)
    AL445199
    Consensus CDS
    CCDS7675.1
    UniProtKB/Swiss-Prot
    O95231, Q32MZ3
    Related
    ENSP00000357556.5, ENST00000325980.10
    Conserved Domains (1) summary
    pfam00046
    Location:95147
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133237855..133241928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134193345..134197419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)