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TINAG tubulointerstitial nephritis antigen [ Homo sapiens (human) ]

Gene ID: 27283, updated on 1-Jun-2020

Summary

Official Symbol
TINAGprovided by HGNC
Official Full Name
tubulointerstitial nephritis antigenprovided by HGNC
Primary source
HGNC:HGNC:14599
See related
Ensembl:ENSG00000137251 MIM:606749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIN-AG
Summary
This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]
Expression
Biased expression in kidney (RPKM 36.8), colon (RPKM 4.4) and 2 other tissues See more
Orthologs

Genomic context

See TINAG in Genome Data Viewer
Location:
6p12.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (54307792..54390151)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (54173203..54254950)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene muscular LMNA interacting protein Neighboring gene uncharacterized LOC105375097 Neighboring gene uncharacterized LOC105375098 Neighboring gene TINAG antisense RNA 1 Neighboring gene chloride nucleotide-sensitive channel 1A pseudogene 1 Neighboring gene ribosomal protein L10 pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
nucleotide binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tubulointerstitial nephritis antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014464.4NP_055279.3  tubulointerstitial nephritis antigen

    See identical proteins and their annotated locations for NP_055279.3

    Status: REVIEWED

    Source sequence(s)
    AK312918, AW027949, BC070278
    Consensus CDS
    CCDS4955.1
    UniProtKB/Swiss-Prot
    Q9UJW2
    UniProtKB/TrEMBL
    Q6NSC1
    Related
    ENSP00000259782.4, ENST00000259782.9
    Conserved Domains (3) summary
    cd02620
    Location:218466
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam01033
    Location:61104
    Somatomedin_B; Somatomedin B domain
    cl17735
    Location:120154
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    54307792..54390151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715062.2XP_006715125.1  tubulointerstitial nephritis antigen isoform X1

    Conserved Domains (3) summary
    cd02620
    Location:200448
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam01033
    Location:4386
    Somatomedin_B; Somatomedin B domain
    cl17735
    Location:102136
    VWC; von Willebrand factor type C domain
  2. XM_017010747.1XP_016866236.1  tubulointerstitial nephritis antigen isoform X5

  3. XM_017010746.1XP_016866235.1  tubulointerstitial nephritis antigen isoform X4

  4. XM_011514497.2XP_011512799.1  tubulointerstitial nephritis antigen isoform X3

    Conserved Domains (2) summary
    cd02620
    Location:168416
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam01033
    Location:61104
    Somatomedin_B; Somatomedin B domain
  5. XM_017010745.1XP_016866234.1  tubulointerstitial nephritis antigen isoform X2

  6. XM_017010748.1XP_016866237.1  tubulointerstitial nephritis antigen isoform X6

RNA

  1. XR_001743344.2 RNA Sequence

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