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Prss43 serine protease 43 [ Mus musculus (house mouse) ]

Gene ID: 272643, updated on 11-Apr-2024

Summary

Official Symbol
Prss43provided by MGI
Official Full Name
serine protease 43provided by MGI
Primary source
MGI:MGI:2684822
See related
Ensembl:ENSMUSG00000058398 AllianceGenome:MGI:2684822
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm661; Tessp3
Summary
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within germ cell development and spermatogenesis. Is anchored component of plasma membrane. Is expressed in cerebral cortex mantle layer; diencephalon lateral wall mantle layer; midbrain mantle layer; pretectum; and telencephalon mantle layer. Orthologous to human PRSS43P (serine protease 43, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 13.7) See more
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Genomic context

Location:
9 F2; 9 60.79 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110655758..110660575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110826690..110831507)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene serine protease 42 Neighboring gene serine protease 44 Neighboring gene serine protease 45 Neighboring gene serine protease 46

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within germ cell development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease 43
Names
protease, serine 43
putative inactive serine protease 43
testis serine protease 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199471.1NP_955765.1  serine protease 43 precursor

    See identical proteins and their annotated locations for NP_955765.1

    Status: PROVISIONAL

    Source sequence(s)
    AB100999
    Consensus CDS
    CCDS23574.1
    UniProtKB/Swiss-Prot
    Q76HL1
    Related
    ENSMUSP00000076752.6, ENSMUST00000077549.7
    Conserved Domains (1) summary
    cd00190
    Location:117351
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110655758..110660575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)