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Plek2 pleckstrin 2 [ Mus musculus (house mouse) ]

Gene ID: 27260, updated on 5-Mar-2024

Summary

Official Symbol
Plek2provided by MGI
Official Full Name
pleckstrin 2provided by MGI
Primary source
MGI:MGI:1351466
See related
Ensembl:ENSMUSG00000021118 AllianceGenome:MGI:1351466
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables phosphatidylinositol-3,4-bisphosphate binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Involved in actin cytoskeleton reorganization and positive regulation of plasma membrane bounded cell projection assembly. Acts upstream of or within actin cytoskeleton organization and positive regulation of cell projection organization. Located in plasma membrane. Orthologous to human PLEK2 (pleckstrin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 12.3), liver E14 (RPKM 12.0) and 11 other tissues See more
Orthologs
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Genomic context

See Plek2 in Genome Data Viewer
Location:
12 C3; 12 35.51 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (78935465..78955166, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (78888691..78907172, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32577 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit D Neighboring gene STARR-seq mESC enhancer starr_32578 Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha Neighboring gene STARR-seq mESC enhancer starr_32580 Neighboring gene predicted gene, 46359 Neighboring gene STARR-seq mESC enhancer starr_32581 Neighboring gene predicted gene, 46360 Neighboring gene transmembrane protein 229B Neighboring gene STARR-seq mESC enhancer starr_32582 Neighboring gene STARR-seq mESC enhancer starr_32583

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013738.3NP_038766.1  pleckstrin-2

    See identical proteins and their annotated locations for NP_038766.1

    Status: PROVISIONAL

    Source sequence(s)
    BC028902
    Consensus CDS
    CCDS26004.1
    UniProtKB/Swiss-Prot
    Q9WV52
    Related
    ENSMUSP00000021544.8, ENSMUST00000021544.8
    Conserved Domains (4) summary
    cd04444
    Location:128236
    DEP_PLEK2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 2-like proteins. Pleckstrin 2 is found in a wide variety of cell types, which suggest a more general role in signaling than pleckstrin 1. Pleckstrin-like proteins contain a central ...
    cd13301
    Location:3113
    PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
    cd13302
    Location:243353
    PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:595
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    78935465..78955166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157436.1XP_036013329.1  pleckstrin-2 isoform X2

    Conserved Domains (2) summary
    cd13302
    Location:108218
    PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
    cl02442
    Location:1101
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
  2. XM_006515934.4XP_006515997.1  pleckstrin-2 isoform X1

    Conserved Domains (3) summary
    cd04444
    Location:73181
    DEP_PLEK2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 2-like proteins. Pleckstrin 2 is found in a wide variety of cell types, which suggest a more general role in signaling than pleckstrin 1. Pleckstrin-like proteins contain a central ...
    cd13302
    Location:188298
    PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
    cl17171
    Location:1358
    PH-like; Pleckstrin homology-like domain