Format

Send to:

Choose Destination

Tbcel tubulin folding cofactor E-like [ Mus musculus (house mouse) ]

Gene ID: 272589, updated on 12-May-2019

Summary

Official Symbol
Tbcelprovided by MGI
Official Full Name
tubulin folding cofactor E-likeprovided by MGI
Primary source
MGI:MGI:1925543
See related
Ensembl:ENSMUSG00000037287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrrc35; D330014K23; E130107N23Rik
Expression
Ubiquitous expression in liver E14.5 (RPKM 10.3), liver E14 (RPKM 10.2) and 28 other tissues See more
Orthologs

Genomic context

See Tbcel in Genome Data Viewer
Location:
9; 9 A5.1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (42412316..42472276, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (42220400..42280309, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36435 Neighboring gene tectorin alpha Neighboring gene predicted gene 16322 Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene predicted gene, 36590 Neighboring gene predicted gene, 36648

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-chaperonin tubulin folding pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tubulin-specific chaperone cofactor E-like protein
Names
leucine-rich repeat-containing protein 35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357656.2NP_001344585.1  tubulin-specific chaperone cofactor E-like protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC136903, AC156631, AK052261, BB841465
    Conserved Domains (5) summary
    COG4886
    Location:65243
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:96119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:147166
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:209322
    LRR_9; Leucine-rich repeat
    cl00155
    Location:363437
    UBQ; Ubiquitin-like proteins
  2. NM_001357657.2NP_001344586.1  tubulin-specific chaperone cofactor E-like protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC136903, AC156631
    Conserved Domains (5) summary
    COG4886
    Location:47225
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:78101
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:129148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:191304
    LRR_9; Leucine-rich repeat
    cl00155
    Location:345419
    UBQ; Ubiquitin-like proteins
  3. NM_173038.4NP_766626.1  tubulin-specific chaperone cofactor E-like protein isoform b

    See identical proteins and their annotated locations for NP_766626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC136903, AC156631
    Consensus CDS
    CCDS23088.1
    UniProtKB/Swiss-Prot
    Q8C5W3
    Related
    ENSMUSP00000067882.5, ENSMUST00000066148.11
    Conserved Domains (5) summary
    COG4886
    Location:47225
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:78101
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:129148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:191304
    LRR_9; Leucine-rich repeat
    cl00155
    Location:345419
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    42412316..42472276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510395.3XP_006510458.1  tubulin-specific chaperone cofactor E-like protein isoform X3

    See identical proteins and their annotated locations for XP_006510458.1

    Conserved Domains (3) summary
    pfam14580
    Location:28179
    LRR_9; Leucine-rich repeat
    sd00033
    Location:5176
    LRR_RI; leucine-rich repeat [structural motif]
    cl00155
    Location:220294
    UBQ; Ubiquitin-like proteins
  2. XM_006510393.2XP_006510456.1  tubulin-specific chaperone cofactor E-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q8C5W3
    Related
    ENSMUSP00000065125.7, ENSMUST00000066179.13
    Conserved Domains (5) summary
    COG4886
    Location:65243
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:96119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:147166
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:209322
    LRR_9; Leucine-rich repeat
    cl00155
    Location:363437
    UBQ; Ubiquitin-like proteins
  3. XM_006510396.3XP_006510459.1  tubulin-specific chaperone cofactor E-like protein isoform X3

    See identical proteins and their annotated locations for XP_006510459.1

    Conserved Domains (3) summary
    pfam14580
    Location:28179
    LRR_9; Leucine-rich repeat
    sd00033
    Location:5176
    LRR_RI; leucine-rich repeat [structural motif]
    cl00155
    Location:220294
    UBQ; Ubiquitin-like proteins
  4. XM_006510394.3XP_006510457.1  tubulin-specific chaperone cofactor E-like protein isoform X2

    UniProtKB/Swiss-Prot
    Q8C5W3
    Related
    ENSMUSP00000114721.1, ENSMUST00000125995.7
    Conserved Domains (5) summary
    COG4886
    Location:47225
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:78101
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:129148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:191304
    LRR_9; Leucine-rich repeat
    cl00155
    Location:345419
    UBQ; Ubiquitin-like proteins
Support Center