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RNF115 ring finger protein 115 [ Homo sapiens (human) ]

Gene ID: 27246, updated on 9-Feb-2020

Summary

Official Symbol
RNF115provided by HGNC
Official Full Name
ring finger protein 115provided by HGNC
Primary source
HGNC:HGNC:18154
See related
Ensembl:ENSG00000265491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCA2; ZNF364
Expression
Ubiquitous expression in heart (RPKM 16.1), fat (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See RNF115 in Genome Data Viewer
Location:
1q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (145738868..145824095, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145610990..145689005)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NBPF member 25, pseudogene Neighboring gene G protein-coupled receptor 89A Neighboring gene PDZ domain containing 1 Neighboring gene CD160 molecule Neighboring gene RNA polymerase III subunit C Neighboring gene nudix hydrolase 17 Neighboring gene microRNA 6736 Neighboring gene protein inhibitor of activated STAT 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of BCA2 by shRNA enhances HIV-1 replication in Jurkat CD4+ T cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Increased levels of ubiquitinated BCA2 are found in the presence of HIV-1 Gag, suggesting that the auto-ubiquitination activity of BCA2 increases in the absence of target proteins PubMed
gag Replacement of cysteine residues at positions 228 and 231 with alanine in the E3 catalytic domain of BCA2 has no defect in Gag expression or processing, indicating that residues 228 and 231 are required for the antiviral activity of BCA2 PubMed
gag A ligase-dead mutant deltaRING-BCA2 has no defect in Gag expression or processing, indicating that the intact RING-domain is required for the antiviral activity of BCA2 PubMed
gag BCA2 has tetherin-independent antiviral activity, which results in a defect in either Gag expression or processing, impairing virus assembly and release for both HIV-1 and SIV PubMed
gag BCA2 promotes the lysosomal degradation of HIV-1 and SIV Gag proteins and induces changes in the subcellular distribution of Gag PubMed
gag Results from co-immunoprecipitation assays indicate that the N-terminal region (residues 1-147) of BCA2 physically interacts with the MA region (residues 1-165) of HIV-1 Gag PubMed
gag BCA2 induces ubiquitination of both HIV-1 and SIV Gag proteins, resulting in lysine residues K113, K114, and K418 in HIV-1 Gag, and K360 and K419 residues in SIV Gag that are ubiquinated PubMed
gag BCA2 co-localizes with HIV-1 Gag in in CD63+ endosomes/lysosomes PubMed
Vpu vpu HIV-1 Vpu antagonizes the effects of BCA2 on HIV-1 particle production in ""tetherin-positive"" cells PubMed
capsid gag A significant downregulation in the levels of virion-associated CA is observed in cells expressing BCA2 for both wild-type HIV-1 and Vpu-deficient HIV-1 PubMed
matrix gag Results from co-immunoprecipitation assays indicate that the N-terminal region (residues 1-147) of BCA2 physically interacts with HIV-1 MA but not CA and NC proteins PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF115
Names
RING-type E3 ubiquitin transferase RNF115
rabring 7
zinc finger protein 364
NP_055270.1
XP_005273009.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014455.4NP_055270.1  E3 ubiquitin-protein ligase RNF115

    See identical proteins and their annotated locations for NP_055270.1

    Status: VALIDATED

    Source sequence(s)
    AC242845, AF419857, BG684824, HY099262
    Consensus CDS
    CCDS72863.1
    UniProtKB/Swiss-Prot
    Q9Y4L5
    Related
    ENSP00000463650.1, ENST00000582693.5
    Conserved Domains (2) summary
    pfam14369
    Location:1949
    zinc_ribbon_9; zinc-ribbon
    cd16800
    Location:226272
    RING-H2_RNF115; RING finger, H2 subclass, found in RING finger protein 115 (RNF115) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    145738868..145824095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272952.5XP_005273009.1  E3 ubiquitin-protein ligase RNF115 isoform X1

    Conserved Domains (1) summary
    pfam13639
    Location:194236
    zf-RING_2; Ring finger domain

RNA

  1. XR_001737118.2 RNA Sequence

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