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ARHGEF16 Rho guanine nucleotide exchange factor 16 [ Homo sapiens (human) ]

Gene ID: 27237, updated on 24-Nov-2020

Summary

Official Symbol
ARHGEF16provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 16provided by HGNC
Primary source
HGNC:HGNC:15515
See related
Ensembl:ENSG00000130762 MIM:618871
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBR; GEF16
Summary
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]
Expression
Broad expression in duodenum (RPKM 15.0), small intestine (RPKM 12.9) and 17 other tissues See more
Orthologs

Genomic context

See ARHGEF16 in Genome Data Viewer
Location:
1p36.32
Exon count:
18
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (3454589..3481115)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3371147..3397677)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PR/SET domain 16 Neighboring gene uncharacterized LOC105378604 Neighboring gene Sharpr-MPRA regulatory region 11957 Neighboring gene VISTA enhancer hs1912 Neighboring gene MEGF6 intron CAGE-defined mid-level expression enhancer Neighboring gene multiple EGF like domains 6 Neighboring gene uncharacterized LOC105378608

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association of lipid-lowering response to statins in combined study populations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 16
Names
Rho guanine exchange factor (GEF) 16
Rho guanine nucleotide exchange factor (GEF) 16
ephexin-4
ephexin4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014448.4NP_055263.2  rho guanine nucleotide exchange factor 16

    See identical proteins and their annotated locations for NP_055263.2

    Status: REVIEWED

    Source sequence(s)
    AL512413
    Consensus CDS
    CCDS46.2
    UniProtKB/Swiss-Prot
    Q5VV41
    UniProtKB/TrEMBL
    B3KTS4
    Related
    ENSP00000367629.4, ENST00000378378.9
    Conserved Domains (4) summary
    cd11938
    Location:633686
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:489622
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00169
    Location:501620
    PH; PH domain
    pfam00621
    Location:288467
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    3454589..3481115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001051.1XP_016856540.1  rho guanine nucleotide exchange factor 16 isoform X2

    UniProtKB/Swiss-Prot
    Q5VV41
    Conserved Domains (4) summary
    cd11938
    Location:633686
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:489622
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00169
    Location:501620
    PH; PH domain
    pfam00621
    Location:288467
    RhoGEF; RhoGEF domain
  2. XM_017001050.1XP_016856539.1  rho guanine nucleotide exchange factor 16 isoform X2

    UniProtKB/Swiss-Prot
    Q5VV41
    Conserved Domains (4) summary
    cd11938
    Location:633686
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:489622
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00169
    Location:501620
    PH; PH domain
    pfam00621
    Location:288467
    RhoGEF; RhoGEF domain
  3. XM_017001049.1XP_016856538.1  rho guanine nucleotide exchange factor 16 isoform X1

  4. XM_024446454.1XP_024302222.1  rho guanine nucleotide exchange factor 16 isoform X3

    Related
    ENSP00000367624.1, ENST00000378373.5
    Conserved Domains (3) summary
    cd11938
    Location:345398
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:201334
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:1178
    RhoGEF; RhoGEF domain
  5. XM_024446455.1XP_024302223.1  rho guanine nucleotide exchange factor 16 isoform X3

    Related
    ENSP00000367622.2, ENST00000378371.6
    Conserved Domains (3) summary
    cd11938
    Location:345398
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:201334
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:1178
    RhoGEF; RhoGEF domain

RNA

  1. XR_001737117.1 RNA Sequence

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