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ARHGEF16 Rho guanine nucleotide exchange factor 16 [ Homo sapiens (human) ]

Gene ID: 27237, updated on 26-Jan-2024

Summary

Official Symbol
ARHGEF16provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 16provided by HGNC
Primary source
HGNC:HGNC:15515
See related
Ensembl:ENSG00000130762 MIM:618871; AllianceGenome:HGNC:15515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBR; GEF16
Summary
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]
Expression
Broad expression in duodenum (RPKM 15.0), small intestine (RPKM 12.9) and 17 other tissues See more
Orthologs
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Genomic context

See ARHGEF16 in Genome Data Viewer
Location:
1p36.32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (3454665..3481113)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (2959327..2988135)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3371229..3397677)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PR/SET domain 16 Neighboring gene collagen alpha-5(IV) chain-like Neighboring gene VISTA enhancer hs705 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:3191818-3193017 Neighboring gene Sharpr-MPRA regulatory region 1987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3212462-3212962 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:3215870-3217069 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3220731-3221288 Neighboring gene uncharacterized LOC105378604 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:3229262-3230461 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:3231799-3232358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3235695-3236196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3236197-3236696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3237397-3238015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3246879-3247556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3255514-3256329 Neighboring gene VISTA enhancer hs1912 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3268668-3269642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3269643-3270616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3272921-3273812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3273813-3274702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3277409-3277908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:3285513-3286094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3303704-3304204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3304205-3304705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3307961-3308462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3311898-3312581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3312582-3313264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3320127-3320627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3325025-3325602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3332377-3333072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3331680-3332376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3337228-3337728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3350015-3350524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3357159-3357921 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3369311-3370063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3373825-3374576 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7120 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3388131-3388756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3399659-3400494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3400495-3401329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3408710-3409234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3408184-3408709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 119 Neighboring gene MEGF6 intron CAGE-defined mid-level expression enhancer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3439723-3440262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3445841-3446528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3447217-3447902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3449965-3450651 Neighboring gene multiple EGF like domains 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3459643-3460294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3460295-3460948 Neighboring gene MPRA-validated peak19 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3463961-3464599 Neighboring gene uncharacterized LOC105378608 Neighboring gene microRNA 551a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
rho guanine nucleotide exchange factor 16
Names
Rho guanine exchange factor (GEF) 16
Rho guanine nucleotide exchange factor (GEF) 16
ephexin-4
ephexin4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014448.4NP_055263.2  rho guanine nucleotide exchange factor 16

    See identical proteins and their annotated locations for NP_055263.2

    Status: REVIEWED

    Source sequence(s)
    AL512413
    Consensus CDS
    CCDS46.2
    UniProtKB/Swiss-Prot
    Q5VV41, Q86TF0, Q99434
    UniProtKB/TrEMBL
    A0A2X0SFX5, B3KTS4
    Related
    ENSP00000367629.4, ENST00000378378.9
    Conserved Domains (4) summary
    cd11938
    Location:633686
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:489622
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00169
    Location:501620
    PH; PH domain
    pfam00621
    Location:288467
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    3454665..3481113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001051.2XP_016856540.1  rho guanine nucleotide exchange factor 16 isoform X2

    UniProtKB/Swiss-Prot
    Q5VV41, Q86TF0, Q99434
    UniProtKB/TrEMBL
    A0A2X0SFX5, B3KTS4
    Conserved Domains (4) summary
    cd11938
    Location:633686
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:489622
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00169
    Location:501620
    PH; PH domain
    pfam00621
    Location:288467
    RhoGEF; RhoGEF domain
  2. XM_017001049.2XP_016856538.1  rho guanine nucleotide exchange factor 16 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SFX5
  3. XM_047418009.1XP_047273965.1  rho guanine nucleotide exchange factor 16 isoform X4

  4. XM_024446454.2XP_024302222.1  rho guanine nucleotide exchange factor 16 isoform X3

    UniProtKB/TrEMBL
    B4DJM7
    Related
    ENSP00000367624.1, ENST00000378373.5
    Conserved Domains (3) summary
    cd11938
    Location:345398
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:201334
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:1178
    RhoGEF; RhoGEF domain
  5. XM_024446455.2XP_024302223.1  rho guanine nucleotide exchange factor 16 isoform X3

    UniProtKB/TrEMBL
    B4DJM7
    Related
    ENSP00000367622.2, ENST00000378371.6
    Conserved Domains (3) summary
    cd11938
    Location:345398
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:201334
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:1178
    RhoGEF; RhoGEF domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    2959327..2988135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336013.1XP_054191988.1  rho guanine nucleotide exchange factor 16 isoform X2

    UniProtKB/TrEMBL
    B3KTS4
  2. XM_054336012.1XP_054191987.1  rho guanine nucleotide exchange factor 16 isoform X1

    UniProtKB/TrEMBL
    B3KTS4
  3. XM_054336016.1XP_054191991.1  rho guanine nucleotide exchange factor 16 isoform X5

  4. XM_054336014.1XP_054191989.1  rho guanine nucleotide exchange factor 16 isoform X3

    UniProtKB/TrEMBL
    B4DJM7
  5. XM_054336015.1XP_054191990.1  rho guanine nucleotide exchange factor 16 isoform X3

    UniProtKB/TrEMBL
    B4DJM7