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Poln DNA polymerase N [ Mus musculus (house mouse) ]

Gene ID: 272158, updated on 9-Mar-2023

Summary

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Official Symbol
Polnprovided by MGI
Official Full Name
DNA polymerase Nprovided by MGI
Primary source
MGI:MGI:2675617
See related
Ensembl:ENSMUSG00000045102 AllianceGenome:MGI:2675617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POL4P
Summary
Predicted to enable DNA-directed DNA polymerase activity and cyclin binding activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and translesion synthesis. Predicted to act upstream of or within DNA-dependent DNA replication. Predicted to be located in nucleoplasm. Is expressed in stomach and testis. Orthologous to human POLN (DNA polymerase nu). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 3.7), CNS E11.5 (RPKM 2.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Poln in Genome Data Viewer
Location:
5; 5 B2
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34164523..34326870, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34007179..34169526, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1673 Neighboring gene N-acetyltransferase 8-like Neighboring gene RIKEN cDNA 4930557J02 gene Neighboring gene predicted gene, 25918 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene Max dimerization protein 4 Neighboring gene zinc finger, FYVE domain containing 28 Neighboring gene cilia and flagella associated protein 99

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. Takata KI, et al. PLoS Genet, 2017 Jun. PMID 28570559, Free PMC Article
  2. POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308. Marini F, et al. J Biol Chem, 2003 Aug 22. PMID 12794064
  3. Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase. van der Laan R, et al. J Cell Sci, 2004 Oct 1. PMID 15383616
  4. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of Poln in mouse embryonic fibroblasts did not alter cellular sensitivity to mitomycin C, cisplatin, or aldehydes. Pol nu-defective mice had no alteration in DNA end-joining during immunoglobulin class-switching.
    Title: Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.
  2. identification as homolog to Mus308
    Title: POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
involved_in translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase nu
Names
DNA-directed DNA polymerase nu
NP_001276732.1
NP_001276733.1
NP_862905.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289803.1 → NP_001276732.1  DNA polymerase nu isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    AC107709, AK133063, BY585631, CJ083086
    Consensus CDS
    CCDS80262.1
    UniProtKB/Swiss-Prot
    Q7TQ07
    UniProtKB/TrEMBL
    A0A0J9YVA9
    Related
    ENSMUSP00000144578.2, ENSMUST00000202409.2
    Conserved Domains (3) summary
    cd08638
    Location:444 → 838
    DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
    COG0749
    Location:261 → 836
    PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
    cl10012
    Location:314 → 437
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  2. NM_001289804.1 → NP_001276733.1  DNA polymerase nu isoform 3

    See identical proteins and their annotated locations for NP_001276733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    AK133063, BY585631, CJ083086
    Consensus CDS
    CCDS80263.1
    UniProtKB/Swiss-Prot
    Q7TQ07
    UniProtKB/TrEMBL
    A0A0J9YTQ3
    Related
    ENSMUSP00000143793.2, ENSMUST00000202638.4
    Conserved Domains (3) summary
    cd08638
    Location:444 → 812
    DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
    COG0749
    Location:261 → 810
    PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
    cl10012
    Location:314 → 437
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  3. NM_181857.4 → NP_862905.1  DNA polymerase nu isoform 1

    See identical proteins and their annotated locations for NP_862905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC107709, AK133063, BY585631, CJ083086
    Consensus CDS
    CCDS39067.1
    UniProtKB/Swiss-Prot
    Q7TQ07
    UniProtKB/TrEMBL
    A0A0R4J0E3
    Related
    ENSMUSP00000036110.8, ENSMUST00000042954.11
    Conserved Domains (3) summary
    cd08638
    Location:444 → 856
    DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
    COG0749
    Location:261 → 854
    PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
    cl10012
    Location:314 → 437
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34164523..34326870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQ07.2 GenPept UniProtKB/Swiss-Prot:Q7TQ07

Gene LinkOut

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