Format

Send to:

Choose Destination

C5AR2 complement component 5a receptor 2 [ Homo sapiens (human) ]

Gene ID: 27202, updated on 21-Dec-2019

Summary

Official Symbol
C5AR2provided by HGNC
Official Full Name
complement component 5a receptor 2provided by HGNC
Primary source
HGNC:HGNC:4527
See related
Ensembl:ENSG00000134830 MIM:609949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5L2; GPF77; GPR77
Summary
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Broad expression in spleen (RPKM 2.6), appendix (RPKM 1.3) and 16 other tissues See more
Orthologs

Genomic context

See C5AR2 in Genome Data Viewer
Location:
19q13.32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (47331614..47347329)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47835404..47845272)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372427 Neighboring gene Sharpr-MPRA regulatory region 10427 Neighboring gene complement C5a receptor 1 Neighboring gene DExH-box helicase 34 Neighboring gene Meis homeobox 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement component C5a receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
complement component C5a signaling pathway IEA
Inferred from Electronic Annotation
more info
 
complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-6 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of complement activation TAS
Traceable Author Statement
more info
 
regulation of interleukin-8 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C5a anaphylatoxin chemotactic receptor 2
Names
C5a anaphylatoxin chemotactic receptor C5L2
G protein-coupled receptor 77
G protein-coupled receptor C5L2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271749.2NP_001258678.1  C5a anaphylatoxin chemotactic receptor 2

    See identical proteins and their annotated locations for NP_001258678.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AB038237, AC008754, AK313994
    Consensus CDS
    CCDS12699.1
    UniProtKB/Swiss-Prot
    Q9P296
    Related
    ENSP00000472620.1, ENST00000595464.3
    Conserved Domains (1) summary
    pfam00001
    Location:52290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001271750.1NP_001258679.1  C5a anaphylatoxin chemotactic receptor 2

    See identical proteins and their annotated locations for NP_001258679.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AB038237, AC008754, BP370117
    Consensus CDS
    CCDS12699.1
    UniProtKB/Swiss-Prot
    Q9P296
    Conserved Domains (1) summary
    pfam00001
    Location:52290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_018485.3NP_060955.1  C5a anaphylatoxin chemotactic receptor 2

    See identical proteins and their annotated locations for NP_060955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AB038237, AC008754, DA673976
    Consensus CDS
    CCDS12699.1
    UniProtKB/Swiss-Prot
    Q9P296
    Related
    ENSP00000471184.1, ENST00000600626.1
    Conserved Domains (1) summary
    pfam00001
    Location:52290
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    47331614..47347329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526736.2XP_011525038.1  C5a anaphylatoxin chemotactic receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011525038.1

    UniProtKB/Swiss-Prot
    Q9P296
    Conserved Domains (1) summary
    pfam00001
    Location:52290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Support Center