Format

Send to:

Choose Destination

OXGR1 oxoglutarate receptor 1 [ Homo sapiens (human) ]

Gene ID: 27199, updated on 12-Oct-2019

Summary

Official Symbol
OXGR1provided by HGNC
Official Full Name
oxoglutarate receptor 1provided by HGNC
Primary source
HGNC:HGNC:4531
See related
Ensembl:ENSG00000165621 MIM:606922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
aKGR; GPR80; GPR99; P2Y15; P2RY15
Summary
This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Expression
Broad expression in kidney (RPKM 1.0), colon (RPKM 0.6) and 14 other tissues See more
Orthologs

Genomic context

See OXGR1 in Genome Data Viewer
Location:
13q32.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (96985719..96994730, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (97637973..97646984, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268107 Neighboring gene long intergenic non-protein coding RNA 359 Neighboring gene TUB like protein 3 pseudogene 1 Neighboring gene RN7SK pseudogene 7 Neighboring gene uncharacterized LOC112268108 Neighboring gene long intergenic non-protein coding RNA 456

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

General gene information

Markers

Homology

Clone Names

  • MGC119206, MGC119207, MGC119208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
2-oxoglutarate receptor 1
Names
G protein-coupled receptor 80
G-protein coupled receptor 99
P2Y purinoceptor 15
P2Y-like GPCR
P2Y-like nucleotide receptor
alpha-ketoglutarate receptor 1
oxoglutarate (alpha-ketoglutarate) receptor 1
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346194.1NP_001333123.1  2-oxoglutarate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AL356486, DN993601
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q96P68
    UniProtKB/TrEMBL
    B2R986
    Conserved Domains (1) summary
    cd15375
    Location:34313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001346195.1NP_001333124.1  2-oxoglutarate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AL356486, DB204461
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q96P68
    UniProtKB/TrEMBL
    B2R986
    Conserved Domains (1) summary
    cd15375
    Location:34313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001346196.1NP_001333125.1  2-oxoglutarate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AK313684, DN993601
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q96P68
    UniProtKB/TrEMBL
    B2R986
    Related
    ENSP00000438800.1, ENST00000543457.5
    Conserved Domains (1) summary
    cd15375
    Location:34313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001346197.1NP_001333126.1  2-oxoglutarate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon and uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AK313684, AL356486, DB204461
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q96P68
    UniProtKB/TrEMBL
    B2R986
    Conserved Domains (1) summary
    cd15375
    Location:34313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_080818.4NP_543008.3  2-oxoglutarate receptor 1

    See identical proteins and their annotated locations for NP_543008.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AL356486, DN993601
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q96P68
    UniProtKB/TrEMBL
    B2R986
    Related
    ENSP00000298440.1, ENST00000298440.5
    Conserved Domains (1) summary
    cd15375
    Location:34313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    96985719..96994730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521077.3XP_011519379.1  2-oxoglutarate receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011519379.1

    UniProtKB/Swiss-Prot
    Q96P68
    UniProtKB/TrEMBL
    B2R986
    Conserved Domains (1) summary
    cd15375
    Location:34313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
Support Center