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IL17C interleukin 17C [ Homo sapiens (human) ]

Gene ID: 27189, updated on 1-Jun-2020

Summary

Official Symbol
IL17Cprovided by HGNC
Official Full Name
interleukin 17Cprovided by HGNC
Primary source
HGNC:HGNC:5983
See related
Ensembl:ENSG00000124391 MIM:604628
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CX2; IL-17C
Summary
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in endometrium (RPKM 1.7), gall bladder (RPKM 0.2) and 1 other tissue See more
Orthologs

Genomic context

See IL17C in Genome Data Viewer
Location:
16q24.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (88638572..88640468)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88705001..88706882)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ZC3H18 antisense RNA 1 (head to head) Neighboring gene zinc finger CCCH-type containing 18 Neighboring gene cytochrome b-245 alpha chain Neighboring gene mevalonate diphosphate decarboxylase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC126884, MGC138401

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
interleukin-17-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-17C
Names
cytokine CX2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013278.4NP_037410.1  interleukin-17C precursor

    See identical proteins and their annotated locations for NP_037410.1

    Status: REVIEWED

    Source sequence(s)
    AC116552
    Consensus CDS
    CCDS42217.1
    UniProtKB/Swiss-Prot
    Q9P0M4
    Related
    ENSP00000244241.4, ENST00000244241.5
    Conserved Domains (1) summary
    pfam06083
    Location:104192
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    88638572..88640468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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