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SIGLEC9 sialic acid binding Ig like lectin 9 [ Homo sapiens (human) ]

Gene ID: 27180, updated on 1-Aug-2020

Summary

Official Symbol
SIGLEC9provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 9provided by HGNC
Primary source
HGNC:HGNC:10878
See related
Ensembl:ENSG00000129450 MIM:605640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD329; CDw329; FOAP-9; siglec-9; OBBP-LIKE
Expression
Broad expression in appendix (RPKM 3.6), spleen (RPKM 2.9) and 15 other tissues See more
Orthologs

Genomic context

See SIGLEC9 in Genome Data Viewer
Location:
19q13.41
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51124880..51140480)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51628137..51639520)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytosolic thiouridylase subunit 1 Neighboring gene sialic acid binding Ig like lectin 18, pseudogene Neighboring gene sialic acid binding Ig like lectin 7 Neighboring gene uncharacterized LOC101928517 Neighboring gene sialic acid binding Ig like lectin 17, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 9
Names
protein FOAP-9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198558.1NP_001185487.1  sialic acid-binding Ig-like lectin 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185487.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK297043, BP305376
    Consensus CDS
    CCDS56100.1
    UniProtKB/Swiss-Prot
    Q9Y336
    Related
    ENSP00000413861.2, ENST00000440804.7
    Conserved Domains (3) summary
    cd05712
    Location:23140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:258336
    IG_like; Immunoglobulin like
    cl11960
    Location:151222
    Ig; Immunoglobulin domain
  2. NM_014441.3NP_055256.1  sialic acid-binding Ig-like lectin 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_055256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal coding exon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS12825.1
    UniProtKB/Swiss-Prot
    Q9Y336
    Related
    ENSP00000250360.2, ENST00000250360.7
    Conserved Domains (3) summary
    cd05712
    Location:23140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:258336
    IG_like; Immunoglobulin like
    cl11960
    Location:151222
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51124880..51140480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723146.4XP_006723209.1  sialic acid-binding Ig-like lectin 9 isoform X1

    Conserved Domains (3) summary
    cd05712
    Location:23140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:258336
    IG_like; Immunoglobulin like
    cl11960
    Location:151222
    Ig; Immunoglobulin domain
  2. XM_017026596.2XP_016882085.1  sialic acid-binding Ig-like lectin 9 isoform X5

  3. XM_017026595.2XP_016882084.1  sialic acid-binding Ig-like lectin 9 isoform X2

  4. XM_011526730.3XP_011525032.1  sialic acid-binding Ig-like lectin 9 isoform X3

    Conserved Domains (3) summary
    cd05712
    Location:23140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:258336
    IG_like; Immunoglobulin like
    cl11960
    Location:151222
    Ig; Immunoglobulin domain
  5. XM_011526732.3XP_011525034.1  sialic acid-binding Ig-like lectin 9 isoform X4

    Conserved Domains (3) summary
    cd05712
    Location:23140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:258336
    IG_like; Immunoglobulin like
    cl11960
    Location:151222
    Ig; Immunoglobulin domain

RNA

  1. XR_001753663.2 RNA Sequence

  2. XR_001753664.2 RNA Sequence

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