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IL37 interleukin 37 [ Homo sapiens (human) ]

Gene ID: 27178, updated on 12-Sep-2021

Summary

Official Symbol
IL37provided by HGNC
Official Full Name
interleukin 37provided by HGNC
Primary source
HGNC:HGNC:15563
See related
Ensembl:ENSG00000125571 MIM:605510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIL1; FIL1Z; IL-1H; IL-23; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward skin (RPKM 8.8) See more
Orthologs
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Genomic context

See IL37 in Genome Data Viewer
Location:
2q14.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (112911165..112918882)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113668742..113676459)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene X-linked inhibitor of apoptosis pseudogene 3 Neighboring gene uncharacterized LOC105373563 Neighboring gene cyclin dependent kinase 8 pseudogene 2 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 23 Neighboring gene interleukin 36 gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of lung function phenotypes in a founder population.
GeneReviews: Not available
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
GeneReviews: Not available
Inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive
MedGen: CN299111 OMIM: 619398 GeneReviews: Not available
not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-1 receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables interleukin-1 receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-37
Names
FIL1 zeta
IL-1 zeta
IL-1F7b (IL-1H4, IL-1H, IL-1RP1)
IL-1X protein
IL1F7 (canonical product IL-1F7b)
interleukin 1 family member 7
interleukin 1, zeta
interleukin-1 homolog 4
interleukin-1 superfamily z
interleukin-1-related protein
interleukin-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029219.1 RefSeqGene

    Range
    5001..10912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014439.4NP_055254.2  interleukin-37 isoform 1

    See identical proteins and their annotated locations for NP_055254.2

    Status: REVIEWED

    Source sequence(s)
    AC079753
    Consensus CDS
    CCDS2103.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000263326.3, ENST00000263326.8
    Conserved Domains (1) summary
    cl00094
    Location:59204
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. NM_173202.2NP_775294.1  interleukin-37 isoform 2

    See identical proteins and their annotated locations for NP_775294.1

    Status: REVIEWED

    Source sequence(s)
    AC079753
    Consensus CDS
    CCDS2104.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000263327.3, ENST00000352179.7
    Conserved Domains (1) summary
    cl00094
    Location:38183
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  3. NM_173203.2NP_775295.1  interleukin-37 isoform 3

    See identical proteins and their annotated locations for NP_775295.1

    Status: REVIEWED

    Source sequence(s)
    AC079753
    Consensus CDS
    CCDS2105.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000263328.3, ENST00000349806.7
    Conserved Domains (1) summary
    cl00094
    Location:47143
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  4. NM_173204.2NP_775296.1  interleukin-37 isoform 4

    See identical proteins and their annotated locations for NP_775296.1

    Status: REVIEWED

    Source sequence(s)
    AC079753
    Consensus CDS
    CCDS2106.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000309208.3, ENST00000353225.7
    Conserved Domains (1) summary
    cl00094
    Location:68164
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  5. NM_173205.2NP_775297.1  interleukin-37 isoform 5

    See identical proteins and their annotated locations for NP_775297.1

    Status: REVIEWED

    Source sequence(s)
    AC079753
    Consensus CDS
    CCDS2107.1
    UniProtKB/Swiss-Prot
    Q9NZH6
    Related
    ENSP00000309883.2, ENST00000311328.2
    Conserved Domains (1) summary
    cl00094
    Location:33178
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    112911165..112918882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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