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TUBG2 tubulin gamma 2 [ Homo sapiens (human) ]

Gene ID: 27175, updated on 7-Jul-2019

Summary

Official Symbol
TUBG2provided by HGNC
Official Full Name
tubulin gamma 2provided by HGNC
Primary source
HGNC:HGNC:12419
See related
Ensembl:ENSG00000037042 MIM:605785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 19.4), testis (RPKM 16.1) and 25 other tissues See more
Orthologs

Genomic context

See TUBG2 in Genome Data Viewer
Location:
17q21.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42659284..42667006)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40811266..40819024)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit g pseudogene 7 Neighboring gene high mobility group box 3 pseudogene 27 Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H3 Neighboring gene contactin associated protein 1 Neighboring gene C-C motif chemokine receptor 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed
Vpr vpr HIV-1 Vpr-expressing HeLa cells stained with centriole markers pericentrin, gamma-tubulin, and Cen2 contain multiple pairs of centrioles scattered in the perinuclear region, indicating Vpr causes the accumulation of multiple centrosome-like structures PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Recruitment of NuMA to mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Recruitment of NuMA to mitotic centrosomes, organism-specific biosystemThe NuMA protein, which functions as a nuclear matrix protein in interphase (Merdes and Cleveland 1998), redistributes to the cytoplasm following nuclear envelope breakdown where it plays an essen...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131994

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
 
meiotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pericentriolar material IEA
Inferred from Electronic Annotation
more info
 
spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tubulin gamma-2 chain
Names
gamma-2-tubulin
tubulin gamma 2 chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320509.2NP_001307438.1  tubulin gamma-2 chain isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC067852, BE727957, BI819869
    UniProtKB/TrEMBL
    A0A1B4Z394
    Conserved Domains (1) summary
    cd02188
    Location:3444
    gamma_tubulin; The gamma-tubulin family
  2. NM_016437.3NP_057521.1  tubulin gamma-2 chain isoform 2

    See identical proteins and their annotated locations for NP_057521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC108739, DC353745
    Consensus CDS
    CCDS32658.1
    UniProtKB/Swiss-Prot
    Q9NRH3
    Related
    ENSP00000251412.6, ENST00000251412.8
    Conserved Domains (1) summary
    cd02188
    Location:3435
    gamma_tubulin; The gamma-tubulin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42659284..42667006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450699.1XP_024306467.1  tubulin gamma-2 chain isoform X5

    Conserved Domains (1) summary
    cd02188
    Location:66341
    gamma_tubulin; The gamma-tubulin family
  2. XM_017024456.2XP_016879945.1  tubulin gamma-2 chain isoform X8

  3. XM_017024455.2XP_016879944.1  tubulin gamma-2 chain isoform X8

  4. XM_024450698.1XP_024306466.1  tubulin gamma-2 chain isoform X4

    Conserved Domains (1) summary
    cl10017
    Location:7131
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  5. XM_011524614.3XP_011522916.1  tubulin gamma-2 chain isoform X6

    See identical proteins and their annotated locations for XP_011522916.1

    Conserved Domains (1) summary
    cd02188
    Location:7282
    gamma_tubulin; The gamma-tubulin family
  6. XM_024450694.1XP_024306462.1  tubulin gamma-2 chain isoform X1

    Conserved Domains (2) summary
    cd02188
    Location:3293
    gamma_tubulin; The gamma-tubulin family
    pfam16617
    Location:306379
    INTAP; Intersectin and clathrin adaptor AP2 binding region
  7. XM_024450696.1XP_024306464.1  tubulin gamma-2 chain isoform X3

    Conserved Domains (2) summary
    cd02188
    Location:3293
    gamma_tubulin; The gamma-tubulin family
    pfam16617
    Location:306379
    INTAP; Intersectin and clathrin adaptor AP2 binding region
  8. XM_024450695.1XP_024306463.1  tubulin gamma-2 chain isoform X2

    Conserved Domains (2) summary
    cd02188
    Location:3284
    gamma_tubulin; The gamma-tubulin family
    pfam16617
    Location:297370
    INTAP; Intersectin and clathrin adaptor AP2 binding region
  9. XM_024450697.1XP_024306465.1  tubulin gamma-2 chain isoform X4

    Conserved Domains (1) summary
    cl10017
    Location:7131
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  10. XM_017024453.2XP_016879942.1  tubulin gamma-2 chain isoform X6

    Conserved Domains (1) summary
    cd02188
    Location:7282
    gamma_tubulin; The gamma-tubulin family
  11. XM_024450700.1XP_024306468.1  tubulin gamma-2 chain isoform X7

    Conserved Domains (1) summary
    cl10017
    Location:1107
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  12. XM_017024454.2XP_016879943.1  tubulin gamma-2 chain isoform X8

  13. XM_024450703.1XP_024306471.1  tubulin gamma-2 chain isoform X8

  14. XM_024450701.1XP_024306469.1  tubulin gamma-2 chain isoform X7

    Conserved Domains (1) summary
    cl10017
    Location:1107
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  15. XM_024450702.1XP_024306470.1  tubulin gamma-2 chain isoform X7

    Conserved Domains (1) summary
    cl10017
    Location:1107
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
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