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NAAA N-acylethanolamine acid amidase [ Homo sapiens (human) ]

Gene ID: 27163, updated on 20-Apr-2020

Summary

Official Symbol
NAAAprovided by HGNC
Official Full Name
N-acylethanolamine acid amidaseprovided by HGNC
Primary source
HGNC:HGNC:736
See related
Ensembl:ENSG00000138744 MIM:607469
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLT; ASAHL
Summary
This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 15.8), colon (RPKM 14.0) and 24 other tissues See more
Orthologs

Genomic context

See NAAA in Genome Data Viewer
Location:
4q21.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (75910655..75941013, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76831808..76862166, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377284 Neighboring gene RNA, U2 small nuclear 16, pseudogene Neighboring gene protein phosphatase with EF-hand domain 2 Neighboring gene uncharacterized LOC105377285 Neighboring gene SDA1 domain containing 1 Neighboring gene SDAD1 antisense RNA 1 Neighboring gene C-X-C motif chemokine ligand 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
N-acylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal lumen TAS
Traceable Author Statement
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N-acylethanolamine-hydrolyzing acid amidase
Names
ASAH-like protein
acid ceramidase-like protein
NP_001035861.1
NP_001350648.1
NP_055250.2
XP_005262977.1
XP_005262978.1
XP_005262980.1
XP_005262981.1
XP_006714243.1
XP_011530154.1
XP_011530156.1
XP_016863516.1
XP_016863517.1
XP_016863518.1
XP_016863519.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042402.2NP_001035861.1  N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001035861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AB161353, AV723847, BM763257, M92449
    UniProtKB/Swiss-Prot
    Q02083
    Conserved Domains (2) summary
    cd01903
    Location:117323
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:3291
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  2. NM_001363719.2NP_001350648.1  N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AC110615
    Consensus CDS
    CCDS87233.1
    Related
    ENSP00000427641.1, ENST00000507956.5
    Conserved Domains (2) summary
    cd01903
    Location:117323
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:3291
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  3. NM_014435.4NP_055250.2  N-acylethanolamine-hydrolyzing acid amidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_055250.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB161353, BM682921, BM763257, DR156596, W47597
    Consensus CDS
    CCDS43239.1
    UniProtKB/Swiss-Prot
    Q02083
    Related
    ENSP00000286733.4, ENST00000286733.9
    Conserved Domains (2) summary
    cd01903
    Location:117346
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    75910655..75941013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262920.4XP_005262977.1  N-acylethanolamine-hydrolyzing acid amidase isoform X2

    See identical proteins and their annotated locations for XP_005262977.1

    UniProtKB/Swiss-Prot
    Q02083
    Conserved Domains (2) summary
    cd01903
    Location:117346
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  2. XM_017008027.2XP_016863516.1  N-acylethanolamine-hydrolyzing acid amidase isoform X1

  3. XM_006714180.3XP_006714243.1  N-acylethanolamine-hydrolyzing acid amidase isoform X6

    Conserved Domains (2) summary
    cd01903
    Location:117333
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  4. XM_005262924.3XP_005262981.1  N-acylethanolamine-hydrolyzing acid amidase isoform X10

    Conserved Domains (2) summary
    cd01903
    Location:117324
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  5. XM_017008030.2XP_016863519.1  N-acylethanolamine-hydrolyzing acid amidase isoform X8

    Conserved Domains (2) summary
    cd01903
    Location:117323
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  6. XM_005262923.3XP_005262980.1  N-acylethanolamine-hydrolyzing acid amidase isoform X9

    Conserved Domains (2) summary
    cd01903
    Location:117333
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  7. XM_017008028.2XP_016863517.1  N-acylethanolamine-hydrolyzing acid amidase isoform X3

    UniProtKB/Swiss-Prot
    Q02083
    Conserved Domains (2) summary
    cd01903
    Location:117346
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  8. XM_017008029.2XP_016863518.1  N-acylethanolamine-hydrolyzing acid amidase isoform X4

  9. XM_011531852.3XP_011530154.1  N-acylethanolamine-hydrolyzing acid amidase isoform X5

    Conserved Domains (2) summary
    cd01903
    Location:117334
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  10. XM_005262921.4XP_005262978.1  N-acylethanolamine-hydrolyzing acid amidase isoform X7

    Conserved Domains (2) summary
    cd01903
    Location:117334
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
  11. XM_011531854.3XP_011530156.1  N-acylethanolamine-hydrolyzing acid amidase isoform X11

    Conserved Domains (2) summary
    cd01903
    Location:117323
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:32121
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase

RNA

  1. XR_001741202.2 RNA Sequence

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