Format

Send to:

Choose Destination

STK36 serine/threonine kinase 36 [ Homo sapiens (human) ]

Gene ID: 27148, updated on 5-Sep-2021

Summary

Official Symbol
STK36provided by HGNC
Official Full Name
serine/threonine kinase 36provided by HGNC
Primary source
HGNC:HGNC:17209
See related
Ensembl:ENSG00000163482 MIM:607652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FU; CILD46
Summary
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 24.8), gall bladder (RPKM 6.4) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See STK36 in Genome Data Viewer
Location:
2q35
Exon count:
30
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218672049..218702717)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219536809..219567440)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene tubulin tyrosine ligase like 4 Neighboring gene cytochrome P450 family 27 subfamily A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
GeneReviews: Not available
CILIARY DYSKINESIA, PRIMARY, 46
MedGen: CN299795 OMIM: 619436 GeneReviews: Not available
not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1278, DKFZp434N0223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial cilium movement involved in extracellular fluid movement IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of hh target transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of hh target transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in post-embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 36
Names
fused homolog
testicular tissue protein Li 188
NP_001230242.1
NP_001356352.1
NP_056505.2
XP_011509261.1
XP_011509262.1
XP_011509263.1
XP_016859293.1
XP_016859294.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029739.1 RefSeqGene

    Range
    5061..35690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243313.2NP_001230242.1  serine/threonine-protein kinase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2, also known as L-FUdelta24) that is shorter than isoform 1.
    Source sequence(s)
    AA524236, AB033104
    Consensus CDS
    CCDS58750.1
    UniProtKB/Swiss-Prot
    Q9NRP7
    Related
    ENSP00000375954.3, ENST00000392105.7
    Conserved Domains (2) summary
    smart00220
    Location:4254
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:2254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
  2. NM_001369423.1NP_001356352.1  serine/threonine-protein kinase 36 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009974
    Related
    ENSP00000394095.1, ENST00000440309.5
    Conserved Domains (1) summary
    cd14002
    Location:2254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
  3. NM_015690.5NP_056505.2  serine/threonine-protein kinase 36 isoform 1

    See identical proteins and their annotated locations for NP_056505.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as long form or L-FU).
    Source sequence(s)
    AA524236, AB033104, AF200815, DB062910
    Consensus CDS
    CCDS2421.1
    UniProtKB/Swiss-Prot
    Q9NRP7
    UniProtKB/TrEMBL
    A0A140VJW1
    Related
    ENSP00000295709.3, ENST00000295709.8
    Conserved Domains (1) summary
    cd14002
    Location:2254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218672049..218702717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510959.2XP_011509261.1  serine/threonine-protein kinase 36 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:4254
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:2254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
  2. XM_017003804.2XP_016859293.1  serine/threonine-protein kinase 36 isoform X3

    UniProtKB/Swiss-Prot
    Q9NRP7
    Conserved Domains (2) summary
    smart00220
    Location:4254
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:2254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
  3. XM_017003805.2XP_016859294.1  serine/threonine-protein kinase 36 isoform X5

    Conserved Domains (2) summary
    pfam13646
    Location:632727
    HEAT_2; HEAT repeats
    sd00044
    Location:579611
    HEAT; HEAT repeat [structural motif]
  4. XM_011510960.1XP_011509262.1  serine/threonine-protein kinase 36 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:1200
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:1200
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
  5. XM_011510961.1XP_011509263.1  serine/threonine-protein kinase 36 isoform X5

    Conserved Domains (2) summary
    pfam13646
    Location:632727
    HEAT_2; HEAT repeats
    sd00044
    Location:579611
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_922904.2 RNA Sequence

  2. XR_001738704.2 RNA Sequence

Support Center