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Rab5a RAB5A, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 271457, updated on 8-Feb-2024

Summary

Official Symbol
Rab5aprovided by MGI
Official Full Name
RAB5A, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105926
See related
Ensembl:ENSMUSG00000017831 AllianceGenome:MGI:105926
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nnyRab5a; 2410015H04Rik
Summary
Enables GTPase activity and guanyl nucleotide binding activity. Acts upstream of or within endocytosis. Located in several cellular components, including cytoplasmic vesicle; membrane raft; and ruffle. Is expressed in several structures, including brain; cardiovascular system; eye; genitourinary system; and gut. Orthologous to human RAB5A (RAB5A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 27.6), CNS E18 (RPKM 24.0) and 25 other tissues See more
Orthologs
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Genomic context

See Rab5a in Genome Data Viewer
Location:
17 C; 17 27.82 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (53786262..53814706)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (53479234..53507678)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene EF hand domain family, member B Neighboring gene predicted gene, 51426 Neighboring gene STARR-seq mESC enhancer starr_42829 Neighboring gene STARR-seq mESC enhancer starr_42830 Neighboring gene tumor protein, translationally-controlled, pseudogene 7 Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42833 Neighboring gene STARR-seq mESC enhancer starr_42835 Neighboring gene STARR-seq mESC enhancer starr_42837 Neighboring gene K(lysine) acetyltransferase 2B Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42842 Neighboring gene STARR-seq mESC enhancer starr_42845 Neighboring gene STARR-positive B cell enhancer ABC_E8685 Neighboring gene shugoshin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP-dissociation inhibitor binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables guanyl nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance by transcytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in modulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endosome size ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of long-term neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasmic side of early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 
located_in zymogen granule membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-5A
NP_080163.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025887.4NP_080163.1  ras-related protein Rab-5A

    See identical proteins and their annotated locations for NP_080163.1

    Status: PROVISIONAL

    Source sequence(s)
    AC165960
    Consensus CDS
    CCDS28879.1
    UniProtKB/Swiss-Prot
    Q3UCX7, Q4VAA1, Q9CQD1, Q9DCN5
    Related
    ENSMUSP00000017975.6, ENSMUST00000017975.7
    Conserved Domains (1) summary
    cd01860
    Location:20182
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    53786262..53814706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)