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Rab5a RAB5A, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 271457, updated on 17-Nov-2020

Summary

Official Symbol
Rab5aprovided by MGI
Official Full Name
RAB5A, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105926
See related
Ensembl:ENSMUSG00000017831
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI663973; AU021172; nnyRab5a; 2410015H04Rik
Expression
Broad expression in CNS E11.5 (RPKM 27.6), CNS E18 (RPKM 24.0) and 25 other tissues See more
Orthologs

Genomic context

See Rab5a in Genome Data Viewer
Location:
17 C; 17 27.82 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (53786262..53814706)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (53479234..53507678)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (53618559..53647003)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene EF hand domain family, member B Neighboring gene predicted gene, 51426 Neighboring gene tumor protein, translationally-controlled, pseudogene 7 Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene K(lysine) acetyltransferase 2B Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene shugoshin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GDP binding ISO
Inferred from Sequence Orthology
more info
 
GDP-dissociation inhibitor binding ISO
Inferred from Sequence Orthology
more info
 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity ISO
Inferred from Sequence Orthology
more info
 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
guanyl nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
amyloid-beta clearance by transcytosis ISO
Inferred from Sequence Orthology
more info
 
early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
endosome organization ISO
Inferred from Sequence Orthology
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
receptor internalization involved in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of endosome size ISO
Inferred from Sequence Orthology
more info
 
regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
 
viral RNA genome replication ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anchored component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasmic side of early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
endosome membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic early endosome ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
recycling endosome ISO
Inferred from Sequence Orthology
more info
 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
zymogen granule membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-5A
NP_080163.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025887.4NP_080163.1  ras-related protein Rab-5A

    See identical proteins and their annotated locations for NP_080163.1

    Status: PROVISIONAL

    Source sequence(s)
    AC165960
    Consensus CDS
    CCDS28879.1
    UniProtKB/Swiss-Prot
    Q9CQD1
    Related
    ENSMUSP00000017975.5, ENSMUST00000017975.6
    Conserved Domains (1) summary
    cd01860
    Location:20182
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    53786262..53814706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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