Format

Send to:

Choose Destination

FILIP1 filamin A interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 27145, updated on 1-Aug-2020

Summary

Official Symbol
FILIP1provided by HGNC
Official Full Name
filamin A interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:21015
See related
Ensembl:ENSG00000118407 MIM:607307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FILIP
Summary
This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]
Expression
Biased expression in heart (RPKM 16.2), esophagus (RPKM 4.3) and 12 other tissues See more
Orthologs

Genomic context

See FILIP1 in Genome Data Viewer
Location:
6q14.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (75291858..75493800, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (76004607..76203516, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7A2 Neighboring gene transmembrane protein 30A Neighboring gene TMEM30A divergent transcript Neighboring gene high mobility group box 1 pseudogene 39 Neighboring gene uncharacterized LOC101928540 Neighboring gene microRNA 4463 Neighboring gene UBE2V1 pseudogene 15 Neighboring gene RNA, U1 small nuclear 34, pseudogene Neighboring gene ribosomal protein L26 pseudogene 20 Neighboring gene H3 histone pseudogene 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of filamin A interacting protein 1 (FILIP1) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1275

Gene Ontology Provided by GOA

Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
filamin-A-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051931.1 RefSeqGene

    Range
    5115..190825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001289987.3NP_001276916.1  filamin-A-interacting protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC136444, BX647178, DB126435
    UniProtKB/Swiss-Prot
    Q7Z7B0
    Conserved Domains (4) summary
    PRK03918
    Location:208741
    PRK03918; chromosome segregation protein; Provisional
    pfam06156
    Location:389461
    DUF972; Protein of unknown function (DUF972)
    pfam09727
    Location:77258
    CortBP2; Cortactin-binding protein-2
    cl23720
    Location:428532
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_001300866.3NP_001287795.1  filamin-A-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001287795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus and a shorter, distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL080250, AL832009, BC042026, BC136443, DB126435, KF458209
    Consensus CDS
    CCDS75480.1
    UniProtKB/Swiss-Prot
    Q7Z7B0
    Related
    ENSP00000376728.1, ENST00000393004.6
    Conserved Domains (4) summary
    PRK03918
    Location:205738
    PRK03918; chromosome segregation protein; Provisional
    pfam06156
    Location:386458
    DUF972; Protein of unknown function (DUF972)
    pfam09727
    Location:74255
    CortBP2; Cortactin-binding protein-2
    cl23720
    Location:425529
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. NM_015687.5NP_056502.1  filamin-A-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_056502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 5' exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC136443, BX647178, DB126435
    Consensus CDS
    CCDS4984.1
    UniProtKB/Swiss-Prot
    Q7Z7B0
    Related
    ENSP00000237172.7, ENST00000237172.12
    Conserved Domains (4) summary
    PRK03918
    Location:205738
    PRK03918; chromosome segregation protein; Provisional
    pfam06156
    Location:386458
    DUF972; Protein of unknown function (DUF972)
    pfam09727
    Location:74255
    CortBP2; Cortactin-binding protein-2
    cl23720
    Location:425529
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RNA

  1. NR_110608.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple exons and contains an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AL445465, BC110829, DB126435

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    75291858..75493800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248715.5XP_005248772.1  filamin-A-interacting protein 1 isoform X2

    Conserved Domains (4) summary
    PRK03918
    Location:205738
    PRK03918; chromosome segregation protein; Provisional
    pfam06156
    Location:386458
    DUF972; Protein of unknown function (DUF972)
    pfam09727
    Location:74255
    CortBP2; Cortactin-binding protein-2
    cl23720
    Location:425529
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_005248713.4XP_005248770.1  filamin-A-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005248770.1

    UniProtKB/Swiss-Prot
    Q7Z7B0
    Conserved Domains (4) summary
    PRK03918
    Location:205738
    PRK03918; chromosome segregation protein; Provisional
    pfam06156
    Location:386458
    DUF972; Protein of unknown function (DUF972)
    pfam09727
    Location:74255
    CortBP2; Cortactin-binding protein-2
    cl23720
    Location:425529
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. XM_011535756.2XP_011534058.1  filamin-A-interacting protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q7Z7B0
    Related
    ENST00000498523.1
    Conserved Domains (3) summary
    pfam05010
    Location:102328
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam06156
    Location:138210
    DUF972; Protein of unknown function (DUF972)
    cl23720
    Location:177281
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Support Center