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PALD1 phosphatase domain containing paladin 1 [ Homo sapiens (human) ]

Gene ID: 27143, updated on 7-Jan-2024

Summary

Official Symbol
PALD1provided by HGNC
Official Full Name
phosphatase domain containing paladin 1provided by HGNC
Primary source
HGNC:HGNC:23530
See related
Ensembl:ENSG00000107719 MIM:614656; AllianceGenome:HGNC:23530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PALD; KIAA1274
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 5.3), spleen (RPKM 4.7) and 24 other tissues See more
Orthologs
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Genomic context

See PALD1 in Genome Data Viewer
Location:
10q22.1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (70458485..70568450)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (71327903..71438184)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72238523..72328206)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2447 Neighboring gene eukaryotic translation initiation factor 4E binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72194899-72195400 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:72197102-72197282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72199683-72200292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72200293-72200900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72200901-72201510 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72202121-72202730 Neighboring gene Sharpr-MPRA regulatory region 10829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72210316-72210984 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:72214954-72215480 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72215481-72216006 Neighboring gene nodal growth differentiation factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72232724-72233490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72239853-72240495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72240496-72241137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72242631-72243178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72253375-72254035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72258695-72259456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72259457-72260216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72273197-72273732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72273733-72274267 Neighboring gene Sharpr-MPRA regulatory region 14353 Neighboring gene YY1 transcription factor pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:72288493-72289410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72298034-72298719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72297349-72298033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72301641-72302141 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72318935-72319878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72319879-72320822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72344798-72345298 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:72345790-72345956 Neighboring gene Sharpr-MPRA regulatory region 12376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72356137-72356637 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:72385043-72385632 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72391517-72392148 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:72396829-72397014 Neighboring gene perforin 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17237 Neighboring gene Sharpr-MPRA regulatory region 11165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3511 Neighboring gene CRISPRi-validated cis-regulatory element chr10.2252 Neighboring gene Sharpr-MPRA regulatory region 4371 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72442365-72443210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:72447939-72448583 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72453261-72453762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72453763-72454262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72461609-72462110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72462111-72462610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72465820-72466320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72497279-72497778 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17283 Neighboring gene Sharpr-MPRA regulatory region 12298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:72502823-72503626 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72516391-72517350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:72521542-72522311

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1274

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014431.3NP_055246.2  paladin

    See identical proteins and their annotated locations for NP_055246.2

    Status: VALIDATED

    Source sequence(s)
    AC022532, AL355344, BC040163, CN335744
    Consensus CDS
    CCDS31215.1
    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
    Related
    ENSP00000263563.5, ENST00000263563.7
    Conserved Domains (1) summary
    pfam14566
    Location:161330
    PTPlike_phytase; Inositol hexakisphosphate

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    70458485..70568450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539638.3XP_011537940.1  paladin isoform X1

    See identical proteins and their annotated locations for XP_011537940.1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
    Conserved Domains (1) summary
    pfam14566
    Location:161330
    PTPlike_phytase; Inositol hexakisphosphate
  2. XM_047425057.1XP_047281013.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
  3. XM_047425055.1XP_047281011.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
  4. XM_047425056.1XP_047281012.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
  5. XM_047425059.1XP_047281015.1  paladin isoform X2

    UniProtKB/TrEMBL
    A0A8V8TL18, A0A8V8TL47
    Related
    ENSP00000513330.1, ENST00000697547.1
  6. XM_047425058.1XP_047281014.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
  7. XM_011539637.3XP_011537939.1  paladin isoform X1

    See identical proteins and their annotated locations for XP_011537939.1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
    Conserved Domains (1) summary
    pfam14566
    Location:161330
    PTPlike_phytase; Inositol hexakisphosphate
  8. XM_047425060.1XP_047281016.1  paladin isoform X2

    UniProtKB/TrEMBL
    A0A8V8TL18, A0A8V8TL47
  9. XM_017016072.2XP_016871561.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
    Conserved Domains (1) summary
    pfam14566
    Location:161330
    PTPlike_phytase; Inositol hexakisphosphate

RNA

  1. XR_945675.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    71327903..71438184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365549.1XP_054221524.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
  2. XM_054365550.1XP_054221525.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
  3. XM_054365545.1XP_054221520.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
  4. XM_054365548.1XP_054221523.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
  5. XM_054365547.1XP_054221522.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1
  6. XM_054365546.1XP_054221521.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    B2RMS1, B9EGC6, Q5JTK7, Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A8V8TLG1

RNA

  1. XR_008488196.1 RNA Sequence

  2. XR_008488198.1 RNA Sequence

  3. XR_008488197.1 RNA Sequence