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PALD1 phosphatase domain containing paladin 1 [ Homo sapiens (human) ]

Gene ID: 27143, updated on 6-Sep-2022

Summary

Official Symbol
PALD1provided by HGNC
Official Full Name
phosphatase domain containing paladin 1provided by HGNC
Primary source
HGNC:HGNC:23530
See related
Ensembl:ENSG00000107719 MIM:614656; AllianceGenome:HGNC:23530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PALD; KIAA1274
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 5.3), spleen (RPKM 4.7) and 24 other tissues See more
Orthologs
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Genomic context

See PALD1 in Genome Data Viewer
Location:
10q22.1
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (70458485..70568450)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (71348188..71438184)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72238523..72328206)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10829 Neighboring gene nodal growth differentiation factor Neighboring gene Sharpr-MPRA regulatory region 8837 Neighboring gene YY1 transcription factor pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14353 Neighboring gene Sharpr-MPRA regulatory region 12376 Neighboring gene perforin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1274

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014431.3NP_055246.2  paladin

    See identical proteins and their annotated locations for NP_055246.2

    Status: VALIDATED

    Source sequence(s)
    AC022532, AL355344, BC040163, CN335744
    Consensus CDS
    CCDS31215.1
    UniProtKB/Swiss-Prot
    Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A024QZM5
    Related
    ENSP00000263563.5, ENST00000263563.7
    Conserved Domains (1) summary
    pfam14566
    Location:161330
    PTPlike_phytase; Inositol hexakisphosphate

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    70458485..70568450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539638.3XP_011537940.1  paladin isoform X1

    See identical proteins and their annotated locations for XP_011537940.1

    UniProtKB/Swiss-Prot
    Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A024QZM5
    Conserved Domains (1) summary
    pfam14566
    Location:161330
    PTPlike_phytase; Inositol hexakisphosphate
  2. XM_047425057.1XP_047281013.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    Q5JTK8
    UniProtKB/TrEMBL
    A0A024QZM5
  3. XM_047425055.1XP_047281011.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    Q5JTK8
    UniProtKB/TrEMBL
    A0A024QZM5
  4. XM_047425056.1XP_047281012.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    Q5JTK8
    UniProtKB/TrEMBL
    A0A024QZM5
  5. XM_047425059.1XP_047281015.1  paladin isoform X2

    Related
    ENSP00000513330.1, ENST00000697547.1
  6. XM_047425058.1XP_047281014.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    Q5JTK8
    UniProtKB/TrEMBL
    A0A024QZM5
  7. XM_011539637.3XP_011537939.1  paladin isoform X1

    See identical proteins and their annotated locations for XP_011537939.1

    UniProtKB/Swiss-Prot
    Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A024QZM5
    Conserved Domains (1) summary
    pfam14566
    Location:161330
    PTPlike_phytase; Inositol hexakisphosphate
  8. XM_047425060.1XP_047281016.1  paladin isoform X2

  9. XM_017016072.2XP_016871561.1  paladin isoform X1

    UniProtKB/Swiss-Prot
    Q5JTK8, Q9ULE6
    UniProtKB/TrEMBL
    A0A024QZM5
    Conserved Domains (1) summary
    pfam14566
    Location:161330
    PTPlike_phytase; Inositol hexakisphosphate

RNA

  1. XR_945675.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    71348188..71438184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)