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CIDEB cell death inducing DFFA like effector b [ Homo sapiens (human) ]

Gene ID: 27141, updated on 24-Nov-2020

Summary

Official Symbol
CIDEBprovided by HGNC
Official Full Name
cell death inducing DFFA like effector bprovided by HGNC
Primary source
HGNC:HGNC:1977
See related
Ensembl:ENSG00000136305 MIM:604441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in liver (RPKM 36.3), duodenum (RPKM 31.8) and 24 other tissues See more
Orthologs

Genomic context

See CIDEB in Genome Data Viewer
Location:
14q12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24305096..24311435, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24774393..24780576, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene TGM1 promoter region Neighboring gene Rab geranylgeranyltransferase subunit alpha Neighboring gene uncharacterized LOC102725044 Neighboring gene dehydrogenase/reductase 1 Neighboring gene nonconserved acetylation island sequence 81 enhancer Neighboring gene NOP9 nucleolar protein Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor Neighboring gene adenylate cyclase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
bile acid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell death activator CIDE-B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318807.2NP_001305736.1  cell death activator CIDE-B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL096870
    Consensus CDS
    CCDS32056.1
    UniProtKB/Swiss-Prot
    Q9UHD4
    Related
    ENSP00000337731.5, ENST00000336557.9
    Conserved Domains (1) summary
    cd06537
    Location:34114
    CIDE_N_B; CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...
  2. NM_014430.3NP_055245.2  cell death activator CIDE-B

    See identical proteins and their annotated locations for NP_055245.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF190901, AF544398, AI242048, AL096870, BX418750, CB162472, DN997151
    Consensus CDS
    CCDS32056.1
    UniProtKB/Swiss-Prot
    Q9UHD4
    Related
    ENSP00000258807.5, ENST00000258807.5
    Conserved Domains (1) summary
    cd06537
    Location:34114
    CIDE_N_B; CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24305096..24311435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021221.1XP_016876710.1  cell death activator CIDE-B isoform X1

    UniProtKB/Swiss-Prot
    Q9UHD4
    Conserved Domains (1) summary
    cd06537
    Location:34114
    CIDE_N_B; CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...
  2. XM_011536659.3XP_011534961.1  cell death activator CIDE-B isoform X1

    See identical proteins and their annotated locations for XP_011534961.1

    UniProtKB/Swiss-Prot
    Q9UHD4
    Related
    ENSP00000451089.1, ENST00000554411.5
    Conserved Domains (1) summary
    cd06537
    Location:34114
    CIDE_N_B; CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    606074..612413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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