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MORC1 MORC family CW-type zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 27136, updated on 21-Dec-2019

Summary

Official Symbol
MORC1provided by HGNC
Official Full Name
MORC family CW-type zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:7198
See related
Ensembl:ENSG00000114487 MIM:603205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT33; MORC; ZCW6
Summary
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]
Expression
Restricted expression toward testis (RPKM 9.4) See more
Orthologs

Genomic context

See MORC1 in Genome Data Viewer
Location:
3q13.13
Exon count:
32
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (108958248..109118134, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108676814..108836993, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene T cell receptor associated transmembrane adaptor 1 Neighboring gene guanylate cyclase activator 1C Neighboring gene MORC1 antisense RNA 1 Neighboring gene chromosome 3 open reading frame 85 Neighboring gene long intergenic non-protein coding RNA 488

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
NHGRI GWA Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA hypermethylation IEA
Inferred from Electronic Annotation
more info
 
DNA methylation involved in gamete generation IEA
Inferred from Electronic Annotation
more info
 
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA-templated transcription, initiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transposition IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression, epigenetic IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MORC family CW-type zinc finger protein 1
Names
cancer/testis antigen 33
microrchidia, mouse, homolog of

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014429.4NP_055244.3  MORC family CW-type zinc finger protein 1

    See identical proteins and their annotated locations for NP_055244.3

    Status: REVIEWED

    Source sequence(s)
    AC016948, AC112138, BC050307
    Consensus CDS
    CCDS2955.1
    UniProtKB/Swiss-Prot
    Q86VD1
    Related
    ENSP00000232603.5, ENST00000232603.10
    Conserved Domains (3) summary
    pfam07496
    Location:482527
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:293373
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    108958248..109118134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247362.2XP_005247419.1  MORC family CW-type zinc finger protein 1 isoform X2

    Conserved Domains (3) summary
    pfam07496
    Location:512557
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:293373
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  2. XM_011512692.1XP_011510994.1  MORC family CW-type zinc finger protein 1 isoform X3

    Conserved Domains (3) summary
    pfam07496
    Location:484529
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:295375
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  3. XM_011512693.1XP_011510995.1  MORC family CW-type zinc finger protein 1 isoform X5

    Conserved Domains (3) summary
    pfam07496
    Location:514559
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:295375
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  4. XM_011512691.1XP_011510993.1  MORC family CW-type zinc finger protein 1 isoform X1

    Conserved Domains (3) summary
    pfam07496
    Location:514559
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:295375
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  5. XM_011512694.1XP_011510996.1  MORC family CW-type zinc finger protein 1 isoform X6

    Conserved Domains (1) summary
    pfam07496
    Location:415460
    zf-CW; CW-type Zinc Finger
  6. XM_011512696.2XP_011510998.1  MORC family CW-type zinc finger protein 1 isoform X7

    See identical proteins and their annotated locations for XP_011510998.1

    Conserved Domains (2) summary
    pfam07496
    Location:288333
    zf-CW; CW-type Zinc Finger
    cl23750
    Location:69149
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  7. XM_011512697.2XP_011510999.1  MORC family CW-type zinc finger protein 1 isoform X8

    Conserved Domains (1) summary
    pfam07496
    Location:263308
    zf-CW; CW-type Zinc Finger
  8. XM_017006170.1XP_016861659.1  MORC family CW-type zinc finger protein 1 isoform X9

  9. XM_017006169.2XP_016861658.1  MORC family CW-type zinc finger protein 1 isoform X4

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