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MORC1 MORC family CW-type zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 27136, updated on 9-Jun-2025
Official Symbol
MORC1provided by HGNC
Official Full Name
MORC family CW-type zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:7198
See related
Ensembl:ENSG00000114487 MIM:603205; AllianceGenome:HGNC:7198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT33; MORC; ZCW6
Summary
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]
Expression
Restricted expression toward testis (RPKM 9.4) See more
Orthologs
NEW
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See MORC1 in Genome Data Viewer
Location:
3q13.13
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108958248..109118134, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111678481..111838414, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108677095..108836981, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene T cell receptor associated transmembrane adaptor 1 Neighboring gene guanylate cyclase activator 1C Neighboring gene small nucleolar RNA U3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20223 Neighboring gene MORC1 antisense RNA 1 Neighboring gene chromosome 3 open reading frame 85 Neighboring gene long intergenic non-protein coding RNA 488

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
EBI GWAS Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
MORC family CW-type zinc finger protein 1
Names
cancer/testis antigen 33
microrchidia, mouse, homolog of

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014429.4NP_055244.3  MORC family CW-type zinc finger protein 1

    See identical proteins and their annotated locations for NP_055244.3

    Status: REVIEWED

    Source sequence(s)
    AC016948, AC112138, BC050307
    Consensus CDS
    CCDS2955.1
    UniProtKB/Swiss-Prot
    B4DYX1, E7ERX1, Q7L8E2, Q86VD1, Q9NSG7, Q9Y6D4
    Related
    ENSP00000232603.5, ENST00000232603.10
    Conserved Domains (3) summary
    pfam07496
    Location:482527
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:293373
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    108958248..109118134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247362.3XP_005247419.1  MORC family CW-type zinc finger protein 1 isoform X2

    Conserved Domains (3) summary
    pfam07496
    Location:512557
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:293373
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  2. XM_047447968.1XP_047303924.1  MORC family CW-type zinc finger protein 1 isoform X6

  3. XM_011512692.2XP_011510994.1  MORC family CW-type zinc finger protein 1 isoform X3

    Conserved Domains (3) summary
    pfam07496
    Location:484529
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:295375
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  4. XM_011512693.2XP_011510995.1  MORC family CW-type zinc finger protein 1 isoform X5

    Conserved Domains (3) summary
    pfam07496
    Location:514559
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:295375
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  5. XM_011512691.2XP_011510993.1  MORC family CW-type zinc finger protein 1 isoform X1

    Conserved Domains (3) summary
    pfam07496
    Location:514559
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:28160
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl23750
    Location:295375
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  6. XM_011512694.1XP_011510996.1  MORC family CW-type zinc finger protein 1 isoform X7

    Conserved Domains (1) summary
    pfam07496
    Location:415460
    zf-CW; CW-type Zinc Finger
  7. XM_011512696.2XP_011510998.1  MORC family CW-type zinc finger protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011510998.1

    Conserved Domains (2) summary
    pfam07496
    Location:288333
    zf-CW; CW-type Zinc Finger
    cl23750
    Location:69149
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
  8. XM_047447970.1XP_047303926.1  MORC family CW-type zinc finger protein 1 isoform X10

  9. XM_011512697.3XP_011510999.1  MORC family CW-type zinc finger protein 1 isoform X9

    Conserved Domains (1) summary
    pfam07496
    Location:263308
    zf-CW; CW-type Zinc Finger
  10. XM_017006169.3XP_016861658.1  MORC family CW-type zinc finger protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    111678481..111838414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346172.1XP_054202147.1  MORC family CW-type zinc finger protein 1 isoform X2

  2. XM_054346175.1XP_054202150.1  MORC family CW-type zinc finger protein 1 isoform X6

  3. XM_054346173.1XP_054202148.1  MORC family CW-type zinc finger protein 1 isoform X3

  4. XM_054346174.1XP_054202149.1  MORC family CW-type zinc finger protein 1 isoform X5

  5. XM_054346171.1XP_054202146.1  MORC family CW-type zinc finger protein 1 isoform X1

  6. XM_054346176.1XP_054202151.1  MORC family CW-type zinc finger protein 1 isoform X7

  7. XM_054346178.1XP_054202153.1  MORC family CW-type zinc finger protein 1 isoform X8

  8. XM_054346177.1XP_054202152.1  MORC family CW-type zinc finger protein 1 isoform X8

  9. XM_054346180.1XP_054202155.1  MORC family CW-type zinc finger protein 1 isoform X10

  10. XM_054346179.1XP_054202154.1  MORC family CW-type zinc finger protein 1 isoform X9