MORC1 MORC family CW-type zinc finger 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MORC1provided by HGNC
Official Full Name: MORC family CW-type zinc finger 1provided by HGNC
Primary source: HGNC:HGNC:7198
See related: Ensembl:ENSG00000114487 MIM:603205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT33; MORC; ZCW6
Summary: This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]
Expression: Restricted expression toward testis (RPKM 9.4) See more
Orthologs: mouse all
NEW: Try the new Data Table view

Genomic context

Location:: 3q13.13

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
109.20201120	current	GRCh38.p13 (GCF_000001405.39)	3	NC_000003.12 (108958248..109118134, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (108676814..108836993, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study showed that DNA methylation in the MORC1 promoter region significantly correlates with the Beck Depression Inventory score in the examined non-clinical population.
Title: Methylation of MORC1: A possible biomarker for depression?
MORC1 is thus the first identified epigenetic marker of ELS to be present in blood cell progenitors at birth and in the brain in adulthood.
Title: MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. GeneReviews: Not available
Genome-wide diet-gene interaction analyses for risk of colorectal cancer. GeneReviews: Not available

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH122742 (e-PCR)
- UniSTS:134013

AFM211XF4 (e-PCR)
- UniSTS:72890

Homology

Homologs of the MORC1 gene: The MORC1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 175 organisms have orthologs with human gene MORC1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA hypermethylation	IEA Inferred from Electronic Annotation more info
DNA methylation involved in gamete generation	IEA Inferred from Electronic Annotation more info
behavioral fear response	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
multicellular organism development	IEA Inferred from Electronic Annotation more info
negative regulation of DNA-templated transcription, initiation	IEA Inferred from Electronic Annotation more info
negative regulation of transposition	IEA Inferred from Electronic Annotation more info
regulation of gene expression, epigenetic	IEA Inferred from Electronic Annotation more info
spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
male germ cell nucleus	IEA Inferred from Electronic Annotation more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: MORC family CW-type zinc finger protein 1

Names: cancer/testis antigen 33; microrchidia, mouse, homolog of

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Data Table view

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014429.4 → NP_055244.3 MORC family CW-type zinc finger protein 1

See identical proteins and their annotated locations for NP_055244.3

Status: REVIEWED

Source sequence(s)

AC016948, AC112138, BC050307

Consensus CDS

CCDS2955.1

UniProtKB/Swiss-Prot

Q86VD1

Related

ENSP00000232603.5, ENST00000232603.10

Conserved Domains (3) summary

pfam07496
Location:482 → 527

zf-CW; CW-type Zinc Finger

cl00075
Location:28 → 160

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

cl23750
Location:293 → 373

vATP-synt_E; ATP synthase (E/31 kDa) subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p13 Primary Assembly

Range

108958248..109118134 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005247362.2 → XP_005247419.1 MORC family CW-type zinc finger protein 1 isoform X2

Conserved Domains (3) summary

pfam07496
Location:512 → 557

zf-CW; CW-type Zinc Finger

cl00075
Location:28 → 160

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

cl23750
Location:293 → 373

vATP-synt_E; ATP synthase (E/31 kDa) subunit
XM_011512692.1 → XP_011510994.1 MORC family CW-type zinc finger protein 1 isoform X3

Conserved Domains (3) summary

pfam07496
Location:484 → 529

zf-CW; CW-type Zinc Finger

cl00075
Location:28 → 160

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

cl23750
Location:295 → 375

vATP-synt_E; ATP synthase (E/31 kDa) subunit
XM_011512693.1 → XP_011510995.1 MORC family CW-type zinc finger protein 1 isoform X5

Conserved Domains (3) summary

pfam07496
Location:514 → 559

zf-CW; CW-type Zinc Finger

cl00075
Location:28 → 160

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

cl23750
Location:295 → 375

vATP-synt_E; ATP synthase (E/31 kDa) subunit
XM_011512691.1 → XP_011510993.1 MORC family CW-type zinc finger protein 1 isoform X1

Conserved Domains (3) summary

pfam07496
Location:514 → 559

zf-CW; CW-type Zinc Finger

cl00075
Location:28 → 160

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

cl23750
Location:295 → 375

vATP-synt_E; ATP synthase (E/31 kDa) subunit
XM_011512694.1 → XP_011510996.1 MORC family CW-type zinc finger protein 1 isoform X6

Conserved Domains (1) summary

pfam07496
Location:415 → 460

zf-CW; CW-type Zinc Finger
XM_011512696.2 → XP_011510998.1 MORC family CW-type zinc finger protein 1 isoform X7

See identical proteins and their annotated locations for XP_011510998.1

Conserved Domains (2) summary

pfam07496
Location:288 → 333

zf-CW; CW-type Zinc Finger

cl23750
Location:69 → 149

vATP-synt_E; ATP synthase (E/31 kDa) subunit
XM_011512697.2 → XP_011510999.1 MORC family CW-type zinc finger protein 1 isoform X8

Conserved Domains (1) summary

pfam07496
Location:263 → 308

zf-CW; CW-type Zinc Finger
XM_017006170.1 → XP_016861659.1 MORC family CW-type zinc finger protein 1 isoform X9
XM_017006169.2 → XP_016861658.1 MORC family CW-type zinc finger protein 1 isoform X4