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DKKL1 dickkopf like acrosomal protein 1 [ Homo sapiens (human) ]

Gene ID: 27120, updated on 24-Nov-2020

Summary

Official Symbol
DKKL1provided by HGNC
Official Full Name
dickkopf like acrosomal protein 1provided by HGNC
Primary source
HGNC:HGNC:16528
See related
Ensembl:ENSG00000104901 MIM:605418
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGY; CT34; SGY1; SGY-1
Summary
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Expression
Restricted expression toward testis (RPKM 49.6) See more
Orthologs

Genomic context

See DKKL1 in Genome Data Viewer
Location:
19q13.33
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49360520..49375132)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49866466..49878373)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 16 Neighboring gene microRNA 4324 Neighboring gene CD37 molecule Neighboring gene TEA domain transcription factor 2 Neighboring gene uncharacterized LOC101928295 Neighboring gene KASH domain containing 5 Neighboring gene parathyroid hormone 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of testosterone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
penetration of zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dickkopf-like protein 1
Names
cancer/testis antigen 34
dickkopf-like 1
protein soggy-1
soggy
soggy-1
testicular secretory protein Li 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197301.2NP_001184230.1  dickkopf-like protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001184230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AF177398, AY358922, BI826744
    UniProtKB/Swiss-Prot
    Q9UK85
    Related
    ENSP00000472056.1, ENST00000597546.1
  2. NM_001197302.2NP_001184231.1  dickkopf-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001184231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice donor site in the first splice junction, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AF177398, BI826695
    UniProtKB/Swiss-Prot
    Q9UK85
    Related
    ENSP00000472866.1, ENST00000597873.5
  3. NM_014419.4NP_055234.1  dickkopf-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055234.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AY358922
    Consensus CDS
    CCDS12762.1
    UniProtKB/Swiss-Prot
    Q9UK85
    UniProtKB/TrEMBL
    A0A140VK15
    Related
    ENSP00000221498.1, ENST00000221498.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49360520..49375132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526725.1XP_011525027.1  dickkopf-like protein 1 isoform X3

  2. XM_017026593.1XP_016882082.1  dickkopf-like protein 1 isoform X7

  3. XM_011526726.2XP_011525028.1  dickkopf-like protein 1 isoform X4

  4. XM_011526727.2XP_011525029.1  dickkopf-like protein 1 isoform X5

  5. XM_011526728.2XP_011525030.1  dickkopf-like protein 1 isoform X6

  6. XM_011526724.1XP_011525026.1  dickkopf-like protein 1 isoform X1

  7. XM_011526729.1XP_011525031.1  dickkopf-like protein 1 isoform X7

    See identical proteins and their annotated locations for XP_011525031.1

  8. XM_006723142.2XP_006723205.1  dickkopf-like protein 1 isoform X2

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