GK2 glycerol kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GK2provided by HGNC
Official Full Name: glycerol kinase 2provided by HGNC
Primary source: HGNC:HGNC:4291
See related: Ensembl:ENSG00000196475 MIM:600148; AllianceGenome:HGNC:4291
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GKP2; GKTA
Summary: Predicted to enable glycerol kinase activity. Predicted to be involved in several processes, including glycerol-3-phosphate biosynthetic process; sperm mitochondrial sheath assembly; and triglyceride metabolic process. Located in sperm midpiece. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: 4q21.21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (79406361..79408228, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (82742131..82743998, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (80327515..80329382, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of LGALS3, PHB2, MUC1, and GK2 expression with CA15-3 in early-stage breast cancer
Title: Identification of a panel of complex autoantigens (LGALS3, PHB2, MUC1, and GK2) in combination with CA15-3 for the diagnosis of early-stage breast cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4S3232 (e-PCR)
- UniSTS:30282

SHGC-107631 (e-PCR)
- UniSTS:170452

RH123019 (e-PCR)
- UniSTS:135410

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables glycerol kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycerol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol-3-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sperm mitochondrial sheath assembly	IEA Inferred from Electronic Annotation more info
involved_in sperm mitochondrial sheath assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in triglyceride metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
located_in sperm mitochondrial sheath	IEA Inferred from Electronic Annotation more info
located_in sperm mitochondrial sheath	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glycerol kinase 2

Names: ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kinase pseudogene 2; glycerol kinase testis specific 2; testis tissue sperm-binding protein Li 77m

NP_149991.2

EC 2.7.1.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.