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PDE7B phosphodiesterase 7B [ Homo sapiens (human) ]

Gene ID: 27115, updated on 1-Aug-2020

Summary

Official Symbol
PDE7Bprovided by HGNC
Official Full Name
phosphodiesterase 7Bprovided by HGNC
Primary source
HGNC:HGNC:8792
See related
Ensembl:ENSG00000171408 MIM:604645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA472E5.1
Summary
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in ovary (RPKM 3.7), endometrium (RPKM 2.5) and 22 other tissues See more
Orthologs

Genomic context

See PDE7B in Genome Data Viewer
Location:
6q23.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (135851701..136195574)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (136172834..136516709)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378012 Neighboring gene uncharacterized LOC101928326 Neighboring gene uncharacterized LOC101928373 Neighboring gene uncharacterized LOC644135 Neighboring gene cytochrome c oxidase subunit 5B pseudogene 2 Neighboring gene mitochondrial fission regulator 2 Neighboring gene BCL2 associated transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variants associate with serum phosphorus concentration.
NHGRI GWA Catalog
Genome-wide association study and meta-analysis of intraocular pressure.
NHGRI GWA Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88256

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Names
high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase
rolipram-insensitive phosphodiesterase type 7
NP_061818.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011994.1 RefSeqGene

    Range
    5006..348879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018945.4NP_061818.1  cAMP-specific 3',5'-cyclic phosphodiesterase 7B

    See identical proteins and their annotated locations for NP_061818.1

    Status: REVIEWED

    Source sequence(s)
    AB038040, AJ251860, AL138828
    Consensus CDS
    CCDS5175.1
    UniProtKB/Swiss-Prot
    Q9NP56
    Related
    ENSP00000310661.6, ENST00000308191.11
    Conserved Domains (1) summary
    pfam00233
    Location:172392
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    135851701..136195574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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