U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZBTB11 zinc finger and BTB domain containing 11 [ Homo sapiens (human) ]

Gene ID: 27107, updated on 5-Aug-2022

Summary

Official Symbol
ZBTB11provided by HGNC
Official Full Name
zinc finger and BTB domain containing 11provided by HGNC
Primary source
HGNC:HGNC:16740
See related
Ensembl:ENSG00000066422 MIM:618181; AllianceGenome:HGNC:16740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRT69; ZNF913; ZNF-U69274
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleoplasm. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 5.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZBTB11 in Genome Data Viewer
Location:
3q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (101648889..101677132, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (104361496..104389742, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101367733..101395976, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene 7 Neighboring gene RNA, U6 small nuclear 1256, pseudogene Neighboring gene RNY1 pseudogene 12 Neighboring gene endogenous retrovirus group K member 5 Gag polyprotein Neighboring gene ZBTB11 antisense RNA 1 Neighboring gene ribosomal protein L24 Neighboring gene uncharacterized LOC124909402

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13426, MGC133303

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 11

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014415.4NP_055230.2  zinc finger and BTB domain-containing protein 11

    See identical proteins and their annotated locations for NP_055230.2

    Status: VALIDATED

    Source sequence(s)
    AB208862, AC084198, AI636025, AK312859, BC028062, DA907277
    Consensus CDS
    CCDS2943.1
    UniProtKB/Swiss-Prot
    O95625, Q2NKP9
    UniProtKB/TrEMBL
    Q59H97
    Related
    ENSP00000326200.4, ENST00000312938.5
    Conserved Domains (4) summary
    smart00225
    Location:215306
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:681701
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:204305
    BTB; BTB/POZ domain
    pfam13465
    Location:900923
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    101648889..101677132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512689.3XP_011510991.1  zinc finger and BTB domain-containing protein 11 isoform X1

    Related
    ENSP00000510736.1, ENST00000688910.1
    Conserved Domains (4) summary
    smart00225
    Location:150241
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:616636
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:139240
    BTB; BTB/POZ domain
    pfam13465
    Location:835858
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011512690.3XP_011510992.1  zinc finger and BTB domain-containing protein 11 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:397417
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:616639
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    104361496..104389742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)