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CACYBP calcyclin binding protein [ Homo sapiens (human) ]

Gene ID: 27101, updated on 3-Jan-2019

Summary

Official Symbol
CACYBPprovided by HGNC
Official Full Name
calcyclin binding proteinprovided by HGNC
Primary source
HGNC:HGNC:30423
See related
Ensembl:ENSG00000116161 MIM:606186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP; GIG5; PNAS-107; S100A6BP
Summary
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 20.4), ovary (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See CACYBP in Genome Data Viewer
Location:
1q25.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (174999435..175012027)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (174968571..174981163)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAB GTPase activating protein 1 like Neighboring gene uncharacterized LOC101928696 Neighboring gene uncharacterized LOC105371622 Neighboring gene RNA, U6 small nuclear 307, pseudogene Neighboring gene serologically defined colon cancer antigen 3 pseudogene 2 Neighboring gene mitochondrial ribosomal protein S14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of calcyclin binding protein (CACYBP) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gastric Cancer Network 2, organism-specific biosystem (from WikiPathways)
    Gastric Cancer Network 2, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Network generated by Ingenuity Pathway Analysis.
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC87971

Gene Ontology Provided by GOA

Function Evidence Code Pubs
S100 protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
response to growth hormone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
cell body IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope lumen IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calcyclin-binding protein
Names
S100A6-binding protein
Siah-interacting protein (SIP)
growth-inhibiting gene 5 protein
hCacyBP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029961.1 RefSeqGene

    Range
    5001..17593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007214.1NP_001007215.1  calcyclin-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001007215.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, and uses a downstream AUG start codon, as compared to variant 1. The encoded isoform 2 has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK093425, AL035305, AW300675, BQ432793
    Consensus CDS
    CCDS30942.1
    UniProtKB/Swiss-Prot
    Q9HB71
    Related
    ENSP00000479414.1, ENST00000613570.4
    Conserved Domains (3) summary
    cd06468
    Location:32124
    p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...
    pfam09032
    Location:132
    Siah-Interact_N; Siah interacting protein, N terminal
    cl27091
    Location:139174
    SGS; SGS domain
  2. NM_014412.2NP_055227.1  calcyclin-binding protein isoform 1

    See identical proteins and their annotated locations for NP_055227.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL035305, AW300675, CA951015
    Consensus CDS
    CCDS1315.1
    UniProtKB/Swiss-Prot
    Q9HB71
    UniProtKB/TrEMBL
    A0A024R904
    Related
    ENSP00000356652.2, ENST00000367679.6
    Conserved Domains (3) summary
    cd06468
    Location:75167
    p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...
    pfam09032
    Location:475
    Siah-Interact_N; Siah interacting protein, N terminal
    cl27091
    Location:182217
    SGS; SGS domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    174999435..175012027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001046.1XP_016856535.1  calcyclin-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9HB71
    Related
    ENSP00000385771.1, ENST00000405362.1
    Conserved Domains (3) summary
    cd06468
    Location:32124
    p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...
    pfam09032
    Location:132
    Siah-Interact_N; Siah interacting protein, N terminal
    cl27091
    Location:139174
    SGS; SGS domain
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