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FOXP1 forkhead box P1 [ Homo sapiens (human) ]

Gene ID: 27086, updated on 11-Apr-2024

Summary

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Official Symbol
FOXP1provided by HGNC
Official Full Name
forkhead box P1provided by HGNC
Primary source
HGNC:HGNC:3823
See related
Ensembl:ENSG00000114861 MIM:605515; AllianceGenome:HGNC:3823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MFH; QRF1; 12CC4; hFKH1B; HSPC215
Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 7.3), ovary (RPKM 7.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3p13
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (70954708..71583978, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (70991208..71623253, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71003859..71633129, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:70838694-70838912 Neighboring gene high mobility group box 1 pseudogene 36 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:70882268-70882846 Neighboring gene RNA, U6 small nuclear 281, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:70902705-70903904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:70903859-70904359 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:70926235-70926734 Neighboring gene OCT4 hESC enhancer GRCh37_chr3:70976354-70976889 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:70998543-70998739 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:71012492-71013094 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:71025197-71026396 Neighboring gene VISTA enhancer hs864 Neighboring gene VISTA enhancer hs965 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:71114251-71114751 Neighboring gene uncharacterized LOC124906247 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:71128185-71128767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20059 Neighboring gene VISTA enhancer hs1092 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71178876-71179618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:71193639-71194138 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:71205831-71206536 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:71214878-71215027 Neighboring gene NANOG hESC enhancer GRCh37_chr3:71259322-71259867 Neighboring gene VISTA enhancer hs630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:71275618-71276118 Neighboring gene VISTA enhancer hs187 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71354949-71355604 Neighboring gene FOXP1 antisense RNA 1 Neighboring gene uncharacterized LOC124906248 Neighboring gene Sharpr-MPRA regulatory region 6361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20060 Neighboring gene VISTA enhancer hs1116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:71463501-71464005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20063 Neighboring gene Sharpr-MPRA regulatory region 10822 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71546600-71547538 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:71552767-71553966 Neighboring gene Sharpr-MPRA regulatory region 15380 Neighboring gene VISTA enhancer hs1149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14520 Neighboring gene Sharpr-MPRA regulatory region 11865 Neighboring gene microRNA 1284 Neighboring gene uncharacterized LOC105377155 Neighboring gene FOXP1 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion. Kaminskiy Y, et al. Front Immunol, 2022. PMID 36268015, Free PMC Article
  2. The FoxP1 gene regulates lung function, production of matrix metalloproteinases and inflammatory mediators, and viability of lung epithelia. Andreas A, et al. Respir Res, 2022 Oct 11. PMID 36221131, Free PMC Article
  3. Transcription factor FOXP1 mediates vascular endothelial dysfunction in diabetic retinopathy. Zhou Y, et al. Graefes Arch Clin Exp Ophthalmol, 2022 Dec. PMID 35695913
  4. [Clinical features and genetic analysis of three children with mental retardation, language impairment and autistic features due to de novo variants of FOXP1 gene]. Hua R, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2021 Dec 10. PMID 34839505
  5. Impact of FOXP1 rs2687201 genetic variant on the susceptibility to HCV-related hepatocellular carcinoma in Egyptians. Motawi TMK, et al. J Biochem Mol Toxicol, 2022 Mar. PMID 34783112

See all (240) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer.
    Title: NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer.
  2. FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells.
    Title: FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells.
  3. Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
    Title: Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
  4. miR-526b-5p/c-Myc/Foxp1 participates in recurrent spontaneous abortion by regulating the proliferation, migration, and invasion of trophoblasts.
    Title: miR-526b-5p/c-Myc/Foxp1 participates in recurrent spontaneous abortion by regulating the proliferation, migration, and invasion of trophoblasts.
  5. Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging.
    Title: Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging.
  6. FOXP1 inhibits pancreatic cancer growth by transcriptionally regulating IRF1 expression.
    Title: FOXP1 inhibits pancreatic cancer growth by transcriptionally regulating IRF1 expression.
  7. Transcription factor FOXP1 mediates vascular endothelial dysfunction in diabetic retinopathy.
    Title: Transcription factor FOXP1 mediates vascular endothelial dysfunction in diabetic retinopathy.
  8. FOXP1 and FOXO3a Are Prognostic Markers in Gallbladder Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas.
    Title: FOXP1 and FOXO3a Are Prognostic Markers in Gallbladder Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas.
  9. Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion.
    Title: Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion.
  10. miR-150 promotes progressive T cell differentiation via inhibiting FOXP1 and RC3H1.
    Title: miR-150 promotes progressive T cell differentiation via inhibiting FOXP1 and RC3H1.
Submit: New GeneRIF Correction See all GeneRIFs (184)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2020-01-22)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2020-01-22)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
EBI GWAS Catalog
Genome-wide association study and meta-analysis of intraocular pressure.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Impact of ancestry and common genetic variants on QT interval in African Americans.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23741, MGC12942, MGC88572, MGC99551

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear androgen receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T follicular helper cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macrophage activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monocyte activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of B cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoclast development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in osteoclast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-21 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chemokine (C-X-C motif) ligand 2 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of endothelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of macrophage colony-stimulating factor production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of monocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to testosterone IEA
Inferred from Electronic Annotation
more info
  
involved_in striatum development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
forkhead box protein P1
Names
fork head-related protein like B
glutamine-rich factor 1
mac-1-regulated forkhead

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028243.1 RefSeqGene

    Range
    5262..634282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012505.2 → NP_001012523.1  forkhead box protein P1 isoform b

    See identical proteins and their annotated locations for NP_001012523.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate exon in the 3' end, compared to variant 1. The encoded isoform b (previously called isoform 2) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC097634, BC005055, BC068481
    Consensus CDS
    CCDS33785.1
    UniProtKB/Swiss-Prot
    Q9H334
    Related
    ENSP00000318721.3, ENST00000318779.7

  2. NM_001244808.3 → NP_001231737.1  forkhead box protein P1 isoform c

    See identical proteins and their annotated locations for NP_001231737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c, previously called 3) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AC103586, AK122710, BC068481, GD144178
    Consensus CDS
    CCDS58839.1
    UniProtKB/TrEMBL
    Q8TEA2
    Related
    ENSP00000418524.1, ENST00000493089.7
    Conserved Domains (3) summary
    COG5025
    Location:437 → 650
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:302 → 369
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:463 → 544
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  3. NM_001244810.2 → NP_001231739.1  forkhead box protein P1 isoform d

    See identical proteins and their annotated locations for NP_001231739.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon but contains another compared to variant 1. The resulting isoform (d, previously called 4) has the same N- and C-termini but is longer compared to isoform a. This variant encodes the longest isoform, which has been shown to enhance embryonic stem (ES) cell pluripotency and repress ES cell differentiation.
    Source sequence(s)
    AC097634, AC103586, AK122710, BC054505, BC068481, GD144178
    Consensus CDS
    CCDS74964.1
    UniProtKB/TrEMBL
    Q8TEA2
    Related
    ENSP00000498110.1, ENST00000648426.1
    Conserved Domains (2) summary
    pfam16159
    Location:302 → 369
    FOXP-CC; FOXP coiled-coil domain
    cl00061
    Location:464 → 545
    FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins

  4. NM_001244812.3 → NP_001231741.1  forkhead box protein P1 isoform e

    See identical proteins and their annotated locations for NP_001231741.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (e, previously called 5) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AA380962, AC103586, AC104442, AK092383, GD144178
    Consensus CDS
    CCDS58838.1
    UniProtKB/TrEMBL
    Q8TEA2
    Related
    ENSP00000417857.1, ENST00000484350.5
    Conserved Domains (3) summary
    COG5025
    Location:361 → 575
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:226 → 293
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:388 → 469
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  5. NM_001244813.3 → NP_001231742.1  forkhead box protein P1 isoform f

    See identical proteins and their annotated locations for NP_001231742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f, previously called 6) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC097632, AC103586, AK074569, GD144178
    Consensus CDS
    CCDS74963.1
    UniProtKB/TrEMBL
    A0A3B3IT66, B4DMV4
    Related
    ENSP00000497567.1, ENST00000650387.1
    Conserved Domains (3) summary
    COG5025
    Location:337 → 551
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:202 → 269
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:364 → 445
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  6. NM_001244814.3 → NP_001231743.1  forkhead box protein P1 isoform a

    See identical proteins and their annotated locations for NP_001231743.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).
    Source sequence(s)
    AC097632, AC103586, AK074321, DA518749, GD144178
    Consensus CDS
    CCDS2914.1
    UniProtKB/Swiss-Prot
    A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
    UniProtKB/TrEMBL
    A0A024R346, Q548T7, Q8TEA2
    Related
    ENSP00000418102.1, ENST00000498215.7
    Conserved Domains (3) summary
    COG5025
    Location:437 → 651
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:302 → 369
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:464 → 545
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  7. NM_001244815.2 → NP_001231744.2  forkhead box protein P1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC103586, AK027264, DA634017, GD144178
    Consensus CDS
    CCDS74963.1
    UniProtKB/TrEMBL
    A0A3B3IT66, B4DMV4
    Related
    ENSP00000497077.3, ENST00000648748.3
    Conserved Domains (3) summary
    COG5025
    Location:337 → 551
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:202 → 269
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:364 → 445
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  8. NM_001244816.2 → NP_001231745.1  forkhead box protein P1 isoform a

    See identical proteins and their annotated locations for NP_001231745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).
    Source sequence(s)
    AC103586, AF250920, GD144178
    Consensus CDS
    CCDS2914.1
    UniProtKB/Swiss-Prot
    A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
    UniProtKB/TrEMBL
    A0A024R346, Q548T7, Q8TEA2
    Related
    ENSP00000497344.1, ENST00000648380.1
    Conserved Domains (3) summary
    COG5025
    Location:437 → 651
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:302 → 369
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:464 → 545
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  9. NM_001349337.2 → NP_001336266.2  forkhead box protein P1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC097632, AC103586
    Consensus CDS
    CCDS93310.1
    UniProtKB/TrEMBL
    A0A0B4J2F3, A0A5H1ZRR8, B4DMV4
    Related
    ENSP00000420736.3, ENST00000491238.8
    Conserved Domains (3) summary
    COG5025
    Location:336 → 550
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:201 → 268
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:363 → 444
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  10. NM_001349338.3 → NP_001336267.1  forkhead box protein P1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 7, 9, and 13, encodes isoform a.
    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
    Consensus CDS
    CCDS2914.1
    UniProtKB/Swiss-Prot
    A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
    UniProtKB/TrEMBL
    A0A024R346, Q548T7, Q8TEA2
    Related
    ENSP00000497369.1, ENST00000649528.3
    Conserved Domains (3) summary
    COG5025
    Location:437 → 651
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:302 → 369
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:464 → 545
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  11. NM_001349340.3 → NP_001336269.1  forkhead box protein P1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1, 7, 9, and 11 encodes isoform a.
    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
    Consensus CDS
    CCDS2914.1
    UniProtKB/Swiss-Prot
    A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
    UniProtKB/TrEMBL
    A0A024R346, Q548T7, Q8TEA2
    Related
    ENSP00000496990.1, ENST00000649631.1
    Conserved Domains (3) summary
    COG5025
    Location:437 → 651
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:302 → 369
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:464 → 545
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  12. NM_001349341.3 → NP_001336270.1  forkhead box protein P1 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) encodes isoform j.
    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
    Consensus CDS
    CCDS93312.1
    UniProtKB/TrEMBL
    A0A3B3IST0, Q8TEA2
    Related
    ENSP00000497693.2, ENST00000649610.2
    Conserved Domains (3) summary
    COG5025
    Location:436 → 650
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:301 → 368
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:463 → 544
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  13. NM_001349342.3 → NP_001336271.1  forkhead box protein P1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 6, encodes isoform f.
    Source sequence(s)
    AC097632, AC103586
    Consensus CDS
    CCDS74963.1
    UniProtKB/TrEMBL
    A0A3B3IT66, B4DMV4
    Related
    ENSP00000496968.1, ENST00000649592.1
    Conserved Domains (3) summary
    COG5025
    Location:337 → 551
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:202 → 269
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:364 → 445
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  14. NM_001349343.3 → NP_001336272.1  forkhead box protein P1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform i.
    Source sequence(s)
    AC097632, AC103586
    Consensus CDS
    CCDS93310.1
    UniProtKB/TrEMBL
    A0A0B4J2F3, A0A5H1ZRR8, B4DMV4
    Related
    ENSP00000497435.1, ENST00000648794.2
    Conserved Domains (3) summary
    COG5025
    Location:336 → 550
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:201 → 268
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:363 → 444
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  15. NM_001349344.3 → NP_001336273.1  forkhead box protein P1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform i.
    Source sequence(s)
    AC097632, AC103586
    Consensus CDS
    CCDS93310.1
    UniProtKB/TrEMBL
    A0A0B4J2F3, A0A5H1ZRR8, B4DMV4
    Related
    ENSP00000482847.2, ENST00000614176.5
    Conserved Domains (3) summary
    COG5025
    Location:336 → 550
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:201 → 268
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:363 → 444
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  16. NM_001370548.1 → NP_001357477.1  forkhead box protein P1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC097632, AC103586
    Consensus CDS
    CCDS93311.1
    UniProtKB/TrEMBL
    A0A3B3IRW5, A0A3B3IS20, B4DMV4
    Related
    ENSP00000496841.3, ENST00000649695.3
    Conserved Domains (3) summary
    COG5025
    Location:337 → 550
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:202 → 269
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:363 → 444
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

  17. NM_032682.6 → NP_116071.2  forkhead box protein P1 isoform a

    See identical proteins and their annotated locations for NP_116071.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a (previously called isoform 1). Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).
    Source sequence(s)
    AC097634, AC103586, AK122710, BC068481
    Consensus CDS
    CCDS2914.1
    UniProtKB/Swiss-Prot
    A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1
    UniProtKB/TrEMBL
    A0A024R346, Q548T7, Q8TEA2
    Related
    ENSP00000318902.5, ENST00000318789.11
    Conserved Domains (3) summary
    COG5025
    Location:437 → 651
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    pfam16159
    Location:302 → 369
    FOXP-CC; FOXP coiled-coil domain
    cd20065
    Location:464 → 545
    FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)

RNA

  1. NR_146142.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058

  2. NR_146143.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    70954708..71583978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    70991208..71623253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H334.1 GenPept UniProtKB/Swiss-Prot:Q9H334

Gene LinkOut

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