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FOXP1 forkhead box P1 [ Homo sapiens (human) ]

Gene ID: 27086, updated on 12-Aug-2018

Summary

Official Symbol
FOXP1provided by HGNC
Official Full Name
forkhead box P1provided by HGNC
Primary source
HGNC:HGNC:3823
See related
Ensembl:ENSG00000114861 MIM:605515; Vega:OTTHUMG00000158803
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MFH; QRF1; 12CC4; hFKH1B; HSPC215
Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 7.3), ovary (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See FOXP1 in Genome Data Viewer
Location:
3p13
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (70954714..71583989, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71003865..71633140, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 36 Neighboring gene RNA, U6 small nuclear 281, pseudogene Neighboring gene VISTA enhancer hs864 Neighboring gene VISTA enhancer hs965 Neighboring gene VISTA enhancer hs1092 Neighboring gene VISTA enhancer hs630 Neighboring gene VISTA enhancer hs187 Neighboring gene FOXP1 antisense RNA 1 Neighboring gene VISTA enhancer hs1116 Neighboring gene VISTA enhancer hs1149 Neighboring gene microRNA 1284 Neighboring gene uncharacterized LOC105377155 Neighboring gene eukaryotic translation initiation factor 4E family member 3 Neighboring gene G protein-coupled receptor 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Mental retardation with language impairment and with or without autistic features
MedGen: C3150923 OMIM: 613670 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2013-04-11)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2013-04-11)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
NHGRI GWA Catalog
Genome-wide association study and meta-analysis of intraocular pressure.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
Impact of ancestry and common genetic variants on QT interval in African Americans.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Transcriptional regulation of pluripotent stem cells, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of pluripotent stem cells, organism-specific biosystemPluripotent stem cells are undifferentiated cells posessing an abbreviated cell cycle (reviewed in Stein et al. 2012), a characteristic profile of gene expression (Rao et al. 2004, Kim et al. 2006, P...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23741, MGC12942, MGC88572, MGC99551

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
androgen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein self-association IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T follicular helper cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cardiovascular system development IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionomycin IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
chemokine (C-C motif) ligand 2 secretion IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin V(D)J recombination IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
innate vocalization behavior IEA
Inferred from Electronic Annotation
more info
 
interleukin-21 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
lung secretory cell differentiation IEA
Inferred from Electronic Annotation
more info
 
macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
monocyte activation IDA
Inferred from Direct Assay
more info
PubMed 
motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lung goblet cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hydrogen peroxide-induced cell death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
pre-B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of action potential IEA
Inferred from Electronic Annotation
more info
 
regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endothelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-12 secretion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of macrophage colony-stimulating factor production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of monocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
sarcomere organization IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
smooth muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance TAS
Traceable Author Statement
more info
 
striatum development IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
ventral spinal cord development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
forkhead box protein P1
Names
fork head-related protein like B
glutamine-rich factor 1
mac-1-regulated forkhead

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028243.1 RefSeqGene

    Range
    5001..634276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012505.1NP_001012523.1  forkhead box protein P1 isoform b

    See identical proteins and their annotated locations for NP_001012523.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate exon in the 3' end, compared to variant 1. The encoded isoform b (previously called isoform 2) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC097634, BC005055, BC068481
    Consensus CDS
    CCDS33785.1
    UniProtKB/Swiss-Prot
    Q9H334
    Related
    ENSP00000318721.3, OTTHUMP00000213508, ENST00000318779.7, OTTHUMT00000352262
  2. NM_001244808.1NP_001231737.1  forkhead box protein P1 isoform c

    See identical proteins and their annotated locations for NP_001231737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c, previously called 3) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AC103586, AK122710, BC068481, GD144178
    Consensus CDS
    CCDS58839.1
    UniProtKB/Swiss-Prot
    Q9H334
    Related
    ENSP00000418524.1, OTTHUMP00000213500, ENST00000493089.6, OTTHUMT00000352251
    Conserved Domains (2) summary
    cd00059
    Location:464536
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  3. NM_001244810.1NP_001231739.1  forkhead box protein P1 isoform d

    See identical proteins and their annotated locations for NP_001231739.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon but contains another compared to variant 1. The resulting isoform (d, previously called 4) has the same N- and C-termini but is longer compared to isoform a. This variant encodes the longest isoform, which has been shown to enhance embryonic stem (ES) cell pluripotency and repress ES cell differentiation.
    Source sequence(s)
    AC097634, AC103586, AK122710, BC054505, BC068481, GD144178
    Consensus CDS
    CCDS74964.1
    UniProtKB/Swiss-Prot
    Q9H334
    Related
    ENSP00000484803.1, ENST00000615603.4
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  4. NM_001244812.1NP_001231741.1  forkhead box protein P1 isoform e

    See identical proteins and their annotated locations for NP_001231741.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (e, previously called 5) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AA380962, AC103586, AK092383, GD144178
    Consensus CDS
    CCDS58838.1
    UniProtKB/Swiss-Prot
    Q9H334
    Related
    ENSP00000417857.1, OTTHUMP00000213503, ENST00000484350.5, OTTHUMT00000352254
    Conserved Domains (2) summary
    cd00059
    Location:389461
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:226293
    FOXP-CC; FOXP coiled-coil domain
  5. NM_001244813.1NP_001231742.1  forkhead box protein P1 isoform f

    See identical proteins and their annotated locations for NP_001231742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f, previously called 6) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC103586, AK074569, GD144178
    Consensus CDS
    CCDS74963.1
    UniProtKB/TrEMBL
    A0A0B4J2F3, Q8N2P0
    Related
    ENSP00000482847.1, ENST00000614176.4
    Conserved Domains (2) summary
    cd00059
    Location:365437
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:202269
    FOXP-CC; FOXP coiled-coil domain
  6. NM_001244814.1NP_001231743.1  forkhead box protein P1 isoform a

    See identical proteins and their annotated locations for NP_001231743.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).
    Source sequence(s)
    AC097632, AC103586, AK074321, DA518749, GD144178
    Consensus CDS
    CCDS2914.1
    UniProtKB/Swiss-Prot
    Q9H334
    UniProtKB/TrEMBL
    Q548T7, Q8TEA2
    Related
    ENSP00000418102.1, OTTHUMP00000213504, ENST00000498215.6, OTTHUMT00000352255
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  7. NM_001244815.1NP_001231744.1  forkhead box protein P1 isoform g

    See identical proteins and their annotated locations for NP_001231744.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (g, previously called 8) has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC103586, AK027264, DA634017, GD144178
    Consensus CDS
    CCDS58837.1
    UniProtKB/Swiss-Prot
    Q9H334
    Related
    ENSP00000420736.1, OTTHUMP00000213506, ENST00000491238.5, OTTHUMT00000352260
    Conserved Domains (2) summary
    cd00059
    Location:467539
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:304371
    FOXP-CC; FOXP coiled-coil domain
  8. NM_001244816.1NP_001231745.1  forkhead box protein P1 isoform a

    See identical proteins and their annotated locations for NP_001231745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).
    Source sequence(s)
    AC103586, AF250920, GD144178
    Consensus CDS
    CCDS2914.1
    UniProtKB/Swiss-Prot
    Q9H334
    UniProtKB/TrEMBL
    Q548T7
    Related
    ENSP00000419393.1, OTTHUMP00000213502, ENST00000475937.5, OTTHUMT00000352253
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  9. NM_001349337.1NP_001336266.1  forkhead box protein P1 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) encodes isoform h.
    Source sequence(s)
    AC097632, AC103586
    Conserved Domains (2) summary
    cd00059
    Location:466538
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:303370
    FOXP-CC; FOXP coiled-coil domain
  10. NM_001349338.1NP_001336267.1  forkhead box protein P1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 7, 9, and 13, encodes isoform a.
    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
    Consensus CDS
    CCDS2914.1
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  11. NM_001349340.1NP_001336269.1  forkhead box protein P1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1, 7, 9, and 11 encodes isoform a.
    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
    Consensus CDS
    CCDS2914.1
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  12. NM_001349341.1NP_001336270.1  forkhead box protein P1 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) encodes isoform j.
    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
    Conserved Domains (2) summary
    cd00059
    Location:464536
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:301368
    FOXP-CC; FOXP coiled-coil domain
  13. NM_001349342.1NP_001336271.1  forkhead box protein P1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 6, encodes isoform f.
    Source sequence(s)
    AC097632, AC103586
    Consensus CDS
    CCDS74963.1
    Conserved Domains (2) summary
    cd00059
    Location:365437
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:202269
    FOXP-CC; FOXP coiled-coil domain
  14. NM_001349343.1NP_001336272.1  forkhead box protein P1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform i.
    Source sequence(s)
    AC097632, AC103586
    Conserved Domains (2) summary
    cd00059
    Location:364436
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:201268
    FOXP-CC; FOXP coiled-coil domain
  15. NM_001349344.1NP_001336273.1  forkhead box protein P1 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform i.
    Source sequence(s)
    AC097632, AC103586
    Conserved Domains (2) summary
    cd00059
    Location:364436
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:201268
    FOXP-CC; FOXP coiled-coil domain
  16. NM_032682.5NP_116071.2  forkhead box protein P1 isoform a

    See identical proteins and their annotated locations for NP_116071.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a (previously called isoform 1). Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).
    Source sequence(s)
    AC097634, AC103586, AK122710, BC068481, GD144178
    Consensus CDS
    CCDS2914.1
    UniProtKB/Swiss-Prot
    Q9H334
    UniProtKB/TrEMBL
    Q548T7
    Related
    ENSP00000318902.4, OTTHUMP00000213499, ENST00000318789.9, OTTHUMT00000352250
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain

RNA

  1. NR_146142.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058
  2. NR_146143.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC097632, AC097634, AC103586, AC104442, AC104645, AC138058

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    70954714..71583989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533585.3XP_011531887.1  forkhead box protein P1 isoform X2

    See identical proteins and their annotated locations for XP_011531887.1

    UniProtKB/Swiss-Prot
    Q9H334
    UniProtKB/TrEMBL
    Q548T7
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  2. XM_006713102.2XP_006713165.1  forkhead box protein P1 isoform X2

    See identical proteins and their annotated locations for XP_006713165.1

    UniProtKB/Swiss-Prot
    Q9H334
    UniProtKB/TrEMBL
    Q548T7
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  3. XM_017006165.1XP_016861654.1  forkhead box protein P1 isoform X2

    UniProtKB/Swiss-Prot
    Q9H334
    UniProtKB/TrEMBL
    Q548T7
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  4. XM_006713104.2XP_006713167.1  forkhead box protein P1 isoform X2

    See identical proteins and their annotated locations for XP_006713167.1

    UniProtKB/Swiss-Prot
    Q9H334
    UniProtKB/TrEMBL
    Q548T7
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  5. XM_006713103.2XP_006713166.1  forkhead box protein P1 isoform X2

    See identical proteins and their annotated locations for XP_006713166.1

    UniProtKB/Swiss-Prot
    Q9H334
    UniProtKB/TrEMBL
    Q548T7
    Related
    ENSP00000418883.1, OTTHUMP00000213507, ENST00000468577.5, OTTHUMT00000352261
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:302369
    FOXP-CC; FOXP coiled-coil domain
  6. XM_017006167.1XP_016861656.1  forkhead box protein P1 isoform X3

    Related
    ENSP00000418225.2, ENST00000497355.6
    Conserved Domains (2) summary
    cd00059
    Location:465537
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:303370
    FOXP-CC; FOXP coiled-coil domain
  7. XM_005264736.3XP_005264793.1  forkhead box protein P1 isoform X1

    See identical proteins and their annotated locations for XP_005264793.1

    Conserved Domains (2) summary
    cd00059
    Location:466538
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16159
    Location:304371
    FOXP-CC; FOXP coiled-coil domain
  8. XM_017006168.2XP_016861657.1  forkhead box protein P1 isoform X4

    UniProtKB/Swiss-Prot
    Q9H334

RNA

  1. XR_001740102.1 RNA Sequence

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