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LYPD3 LY6/PLAUR domain containing 3 [ Homo sapiens (human) ]

Gene ID: 27076, updated on 13-Mar-2020

Summary

Official Symbol
LYPD3provided by HGNC
Official Full Name
LY6/PLAUR domain containing 3provided by HGNC
Primary source
HGNC:HGNC:24880
See related
Ensembl:ENSG00000124466 MIM:609484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4.4A
Expression
Biased expression in esophagus (RPKM 319.1) and skin (RPKM 226.0) See more
Orthologs

Genomic context

See LYPD3 in Genome Data Viewer
Location:
19q13.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43460787..43465608, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43964946..43969831, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CD177 molecule pseudogene 1 Neighboring gene testis expressed 101 Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene pleckstrin homology like domain family B member 3 Neighboring gene Sharpr-MPRA regulatory region 2471 Neighboring gene ETHE1 persulfide dioxygenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
anchored component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ly6/PLAUR domain-containing protein 3
Names
2310061G07Rik
GPI-anchored metastasis-associated protein C4.4A homolog
GPI-anchored metastasis-associated protein homolog
MIG-C4
matrigel-induced gene C4 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014400.3NP_055215.2  ly6/PLAUR domain-containing protein 3 precursor

    See identical proteins and their annotated locations for NP_055215.2

    Status: VALIDATED

    Source sequence(s)
    AC018758, BC039167, BP367221, DA837818
    Consensus CDS
    CCDS12620.1
    UniProtKB/Swiss-Prot
    O95274
    UniProtKB/TrEMBL
    B2RBR3
    Related
    ENSP00000244333.2, ENST00000244333.4
    Conserved Domains (2) summary
    cd00117
    Location:31116
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    pfam00021
    Location:140222
    UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43460787..43465608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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