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STAU2 staufen double-stranded RNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 27067, updated on 21-Mar-2023

Summary

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Official Symbol
STAU2provided by HGNC
Official Full Name
staufen double-stranded RNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:11371
See related
Ensembl:ENSG00000040341 MIM:605920; AllianceGenome:HGNC:11371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
39K2; 39K3
Summary
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Ubiquitous expression in brain (RPKM 12.9), heart (RPKM 8.7) and 25 other tissues See more
Orthologs
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Genomic context

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See STAU2 in Genome Data Viewer
Location:
8q21.11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (73420369..73747480, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (73850269..74176939, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74332604..74659715, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RDH10 antisense RNA 1 Neighboring gene retinol dehydrogenase 10 Neighboring gene uncharacterized LOC105375899 Neighboring gene STAU2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7553 Neighboring gene VENT homeobox pseudogene 6 Neighboring gene ubiquitin conjugating enzyme E2 W Neighboring gene RNA, 7SL, cytoplasmic 760, pseudogene Neighboring gene long intergenic non-protein coding RNA 1617

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Encapsidation of Staufen-2 Enhances Infectivity of HIV-1. Balakrishnan K, et al. Viruses, 2021 Dec 8. PMID 34960728, Free PMC Article
  2. Quantitative STAU2 measurement in lymphocytes for breast cancer risk assessment. Puttipanyalears C, et al. Sci Rep, 2021 Jan 13. PMID 33441653, Free PMC Article
  3. The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis. Zhang X, et al. Nucleic Acids Res, 2016 May 5. PMID 26843428, Free PMC Article
  4. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Park E, et al. Proc Natl Acad Sci U S A, 2013 Jan 8. PMID 23263869, Free PMC Article
  5. STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells. Condé L, et al. BMC Mol Cell Biol, 2021 Mar 4. PMID 33663378, Free PMC Article

See all (91) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.
    Title: Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.
  2. Encapsidation of Staufen-2 Enhances Infectivity of HIV-1.
    Title: Encapsidation of Staufen-2 Enhances Infectivity of HIV-1.
  3. STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells.
    Title: STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells.
  4. Quantitative STAU2 measurement in lymphocytes for breast cancer risk assessment.
    Title: Quantitative STAU2 measurement in lymphocytes for breast cancer risk assessment.
  5. during genotoxic stress, Stau2 is downregulated at the promoter level in an ATR- and E2F1-dependent manner, leading to increased levels of DNA damage and apoptosis.
    Title: The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.
  6. Authors establish that human Staufen-2, a host factor which is up-regulated upon HIV-1 infection, interacts with HIV-1 Rev, thereby promoting its RNA export activity and progeny virus formation.
    Title: Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev.
  7. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.
    Title: Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.
  8. We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression
    Title: Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.
  9. Stau1- and Stau2-mRNPs associate with distinct but overlapping sets of cellular mRNAs.
    Title: A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes.
  10. Data show that Stau2 is localized to the neuronal soma and dendrites, but it does not colocalize with Stau1-containing particles.
    Title: Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with staufen is mediated by staufen's dsRBD3 domain PubMed
gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
Rev rev HIV-1 Rev interacts with human STAU-2 protein in a RNA-independent manner and influences the sub-cellular localization of STAU-2. HIV-1 infection upregulates STAU-2 expression in human T-lymphocytes and astrocytes PubMed
capsid gag Human STAU-2 increases HIV-1 production with upregulated levels of HIV-1 CA PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119606, DKFZp781K0371

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinesin binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in eye morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to synapse IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
part_of messenger ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
double-stranded RNA-binding protein Staufen homolog 2
Names
staufen homolog 2
staufen, RNA binding protein, homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164380.2 → NP_001157852.1  double-stranded RNA-binding protein Staufen homolog 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest isoform (a).
    Source sequence(s)
    AC100784, AF459097, AK002152
    Consensus CDS
    CCDS55247.1
    UniProtKB/Swiss-Prot
    Q9NUL3, Q9UGG6
    UniProtKB/TrEMBL
    A0A0A0MTC5
    Related
    ENSP00000428756.1, ENST00000524300.6
    Conserved Domains (2) summary
    smart00358
    Location:308 → 374
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:459 → 523
    Staufen_C; Staufen C-terminal domain

  2. NM_001164381.2 → NP_001157853.1  double-stranded RNA-binding protein Staufen homolog 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC100784, AF459097, BC008369
    Consensus CDS
    CCDS55248.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    E9PH62
    Related
    ENSP00000428456.1, ENST00000522695.5
    Conserved Domains (2) summary
    smart00358
    Location:276 → 342
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:427 → 491
    Staufen_C; Staufen C-terminal domain

  3. NM_001164382.2 → NP_001157854.1  double-stranded RNA-binding protein Staufen homolog 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC100784, AF459097, AK002152, AK303104
    Consensus CDS
    CCDS55245.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    A0A0A0MTC6
    Related
    ENSP00000429173.1, ENST00000521210.5
    Conserved Domains (3) summary
    smart00358
    Location:204 → 270
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:37 → 75
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:355 → 457
    Staufen_C; Staufen C-terminal domain

  4. NM_001164383.2 → NP_001157855.1  double-stranded RNA-binding protein Staufen homolog 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC100784, AF459097, AK002152, AK293496
    Consensus CDS
    CCDS55244.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    A0A0A0MTC4
    Related
    ENSP00000428741.1, ENST00000523558.5
    Conserved Domains (2) summary
    smart00358
    Location:136 → 202
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:287 → 351
    Staufen_C; Staufen C-terminal domain

  5. NM_001164384.2 → NP_001157856.1  double-stranded RNA-binding protein Staufen homolog 2 isoform e

    See identical proteins and their annotated locations for NP_001157856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (e) has shorter and distinct N- and C-termini compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
    Source sequence(s)
    AB210014, AK001576, AK023314, AK290141, CA311807, Y19062
    Consensus CDS
    CCDS6214.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    A8K276, F8VPI7, Q4LE57
    Related
    ENSP00000427977.1, ENST00000522509.5
    Conserved Domains (5) summary
    pfam16482
    Location:427 → 479
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:66 → 147
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:174 → 240
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:272 → 357
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:6 → 38
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

  6. NM_001164385.2 → NP_001157857.1  double-stranded RNA-binding protein Staufen homolog 2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AB210014, AK001576, AK023314, AK294466, CA311807
    Consensus CDS
    CCDS55246.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    A0A0A0MTD1, Q4LE57
    Related
    ENSP00000431111.1, ENST00000517542.5
    Conserved Domains (2) summary
    smart00358
    Location:270 → 336
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:421 → 473
    Staufen_C; Staufen C-terminal domain

  7. NM_014393.3 → NP_055208.2  double-stranded RNA-binding protein Staufen homolog 2 isoform e

    See identical proteins and their annotated locations for NP_055208.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (e) has shorter and distinct N- and C-termini compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
    Source sequence(s)
    AB210014, AK001576, AK023314, CA311807, DB501161, Y19062
    Consensus CDS
    CCDS6214.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    F8VPI7, Q4LE57
    Related
    ENSP00000348026.5, ENST00000355780.9
    Conserved Domains (5) summary
    pfam16482
    Location:427 → 479
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:66 → 147
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:174 → 240
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:272 → 357
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:6 → 38
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    73420369..73747480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    73850269..74176939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NUL3.2 GenPept UniProtKB/Swiss-Prot:Q9NUL3

Gene LinkOut

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