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STAU2 staufen double-stranded RNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 27067, updated on 6-Jan-2019

Summary

Official Symbol
STAU2provided by HGNC
Official Full Name
staufen double-stranded RNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:11371
See related
Ensembl:ENSG00000040341 MIM:605920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
39K2; 39K3
Summary
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Ubiquitous expression in brain (RPKM 12.9), heart (RPKM 8.7) and 25 other tissues See more
Orthologs

Genomic context

See STAU2 in Genome Data Viewer
Location:
8q21.11
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (73420369..73747708, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74332604..74659943, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RDH10 antisense RNA 1 Neighboring gene retinol dehydrogenase 10 Neighboring gene uncharacterized LOC105375899 Neighboring gene STAU2 antisense RNA 1 Neighboring gene uncharacterized LOC105375902 Neighboring gene VENT homeobox pseudogene 6 Neighboring gene ubiquitin conjugating enzyme E2 W Neighboring gene RNA, 7SL, cytoplasmic 760, pseudogene Neighboring gene long intergenic non-protein coding RNA 1617

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with staufen is mediated by staufen's dsRBD3 domain PubMed
gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
Rev rev HIV-1 Rev interacts with human STAU-2 protein in a RNA-independent manner and influences the sub-cellular localization of STAU-2. HIV-1 infection upregulates STAU-2 expression in human T-lymphocytes and astrocytes PubMed
capsid gag Human STAU-2 increases HIV-1 production with upregulated levels of HIV-1 CA PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119606, DKFZp781K0371

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
double-stranded RNA-binding protein Staufen homolog 2
Names
staufen homolog 2
staufen, RNA binding protein, homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164380.2NP_001157852.1  double-stranded RNA-binding protein Staufen homolog 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest isoform (a).
    Source sequence(s)
    AC100784, AF459097, AK002152
    Consensus CDS
    CCDS55247.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    A0A0A0MTC5
    Related
    ENSP00000428756.1, ENST00000524300.5
    Conserved Domains (2) summary
    smart00358
    Location:308374
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:459523
    Staufen_C; Staufen C-terminal domain
  2. NM_001164381.1NP_001157853.1  double-stranded RNA-binding protein Staufen homolog 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC100784, AF459097, BC008369, DB501161
    Consensus CDS
    CCDS55248.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    E9PH62
    Related
    ENSP00000428456.1, ENST00000522695.5
    Conserved Domains (2) summary
    smart00358
    Location:276342
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:427491
    Staufen_C; Staufen C-terminal domain
  3. NM_001164382.1NP_001157854.1  double-stranded RNA-binding protein Staufen homolog 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC100784, AF459097, AK002152, AK303104, DB501161
    Consensus CDS
    CCDS55245.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    A0A0A0MTC6
    Related
    ENSP00000429173.1, ENST00000521210.5
    Conserved Domains (3) summary
    smart00358
    Location:204270
    DSRM; Double-stranded RNA binding motif
    cd00048
    Location:3775
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam16482
    Location:355457
    Staufen_C; Staufen C-terminal domain
  4. NM_001164383.1NP_001157855.1  double-stranded RNA-binding protein Staufen homolog 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC100784, AF459097, AK002152, AK293496, DB501161
    Consensus CDS
    CCDS55244.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    A0A0A0MTC4
    Related
    ENSP00000428741.1, ENST00000523558.5
    Conserved Domains (2) summary
    smart00358
    Location:136202
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:287351
    Staufen_C; Staufen C-terminal domain
  5. NM_001164384.1NP_001157856.1  double-stranded RNA-binding protein Staufen homolog 2 isoform e

    See identical proteins and their annotated locations for NP_001157856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (e) has shorter and distinct N- and C-termini compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
    Source sequence(s)
    AB210014, AK001576, AK023314, AK290141, CA311807, Y19062
    Consensus CDS
    CCDS6214.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    A8K276, F8VPI7, Q4LE57
    Related
    ENSP00000427977.1, ENST00000522509.5
    Conserved Domains (2) summary
    smart00358
    Location:276342
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:427479
    Staufen_C; Staufen C-terminal domain
  6. NM_001164385.1NP_001157857.1  double-stranded RNA-binding protein Staufen homolog 2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AB210014, AK001576, AK023314, AK294466, CA311807, DB501161
    Consensus CDS
    CCDS55246.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    A0A0A0MTD1, Q4LE57
    Related
    ENSP00000431111.1, ENST00000517542.5
    Conserved Domains (2) summary
    smart00358
    Location:270336
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:421473
    Staufen_C; Staufen C-terminal domain
  7. NM_014393.2NP_055208.2  double-stranded RNA-binding protein Staufen homolog 2 isoform e

    See identical proteins and their annotated locations for NP_055208.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (e) has shorter and distinct N- and C-termini compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
    Source sequence(s)
    AB210014, AK001576, AK023314, CA311807, DB501161, Y19062
    Consensus CDS
    CCDS6214.1
    UniProtKB/Swiss-Prot
    Q9NUL3
    UniProtKB/TrEMBL
    F8VPI7, Q4LE57
    Related
    ENSP00000348026.5, ENST00000355780.9
    Conserved Domains (2) summary
    smart00358
    Location:276342
    DSRM; Double-stranded RNA binding motif
    pfam16482
    Location:427479
    Staufen_C; Staufen C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    73420369..73747708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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