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SIGLEC7 sialic acid binding Ig like lectin 7 [ Homo sapiens (human) ]

Gene ID: 27036, updated on 8-Dec-2018

Summary

Official Symbol
SIGLEC7provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 7provided by HGNC
Primary source
HGNC:HGNC:10876
See related
Ensembl:ENSG00000168995 MIM:604410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
Expression
Broad expression in spleen (RPKM 7.6), appendix (RPKM 5.3) and 14 other tissues See more
Orthologs

Genomic context

See SIGLEC7 in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (51142260..51153526)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51645558..51656783)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 18, pseudogene Neighboring gene sialic acid binding Ig like lectin 9 Neighboring gene uncharacterized LOC101928517 Neighboring gene sialic acid binding Ig like lectin 17, pseudogene Neighboring gene sialic acid binding Ig like lectin 20, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SIGLEC7 binds to HIV-1 gp120 and enhances HIV-1 infection of CD4+ T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 7
Names
AIRM-1
QA79 membrane protein
adhesion inhibitory receptor molecule 1, siglec-7
sialic acid binding immunoglobulin-like lectin 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277201.1NP_001264130.1  sialic acid-binding Ig-like lectin 7 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001264130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks all internal coding exons, compared to variant 1. The resulting isoform (3) is C-terminal truncated, compared to isoform 1.
    Source sequence(s)
    AJ007395, AJ130713, BX644517
    Consensus CDS
    CCDS62771.1
    UniProtKB/Swiss-Prot
    Q9Y286
    Related
    ENSP00000472529.1, ENST00000600577.1
    Conserved Domains (2) summary
    cd05712
    Location:26144
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:31122
    IG_like; Immunoglobulin like
  2. NM_014385.3NP_055200.1  sialic acid-binding Ig-like lectin 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AJ007395, BC028150, BX644517
    Consensus CDS
    CCDS12826.1
    UniProtKB/Swiss-Prot
    Q9Y286
    Related
    ENSP00000323328.6, ENST00000317643.10
    Conserved Domains (3) summary
    cd05712
    Location:26144
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:261336
    IG_like; Immunoglobulin like
    cl11960
    Location:150223
    Ig; Immunoglobulin domain
  3. NM_016543.3NP_057627.2  sialic acid-binding Ig-like lectin 7 isoform 2 precursor

    See identical proteins and their annotated locations for NP_057627.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AJ007395, AJ130711, BX644517
    Consensus CDS
    CCDS42601.1
    UniProtKB/Swiss-Prot
    Q9Y286
    Related
    ENSP00000306757.6, ENST00000305628.7
    Conserved Domains (3) summary
    cd05712
    Location:26144
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:168243
    IG_like; Immunoglobulin like
    pfam13895
    Location:167245
    Ig_2; Immunoglobulin domain

RNA

  1. NR_102350.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ007395, AJ130712, BX644517

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    51142260..51153526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526721.3XP_011525023.1  sialic acid-binding Ig-like lectin 7 isoform X1

    Conserved Domains (3) summary
    cd05712
    Location:26144
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:152227
    IG_like; Immunoglobulin like
    pfam13895
    Location:151229
    Ig_2; Immunoglobulin domain

RNA

  1. XR_002958297.1 RNA Sequence

  2. XR_001753661.1 RNA Sequence

  3. XR_001753662.1 RNA Sequence

  4. XR_001753660.2 RNA Sequence

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