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UL29 single-stranded DNA-binding protein [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703458, updated on 9-Jun-2024
Gene symbol
UL29
Gene description
single-stranded DNA-binding protein
Locus tag
HHV1gp00p46
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Sequence:
NC_001806.2 (58410..62054, complement)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene nuclear protein UL24 Neighboring gene DNA packaging tegument protein UL25 Neighboring gene capsid maturation protease Neighboring gene capsid scaffold protein Neighboring gene envelope glycoprotein B Neighboring gene DNA packaging terminase subunit 2 Neighboring gene DNA polymerase catalytic subunit Neighboring gene nuclear egress lamina protein Neighboring gene DNA packaging protein UL32 Neighboring gene DNA packaging protein UL33 Neighboring gene nuclear egress membrane protein Neighboring gene small capsid protein

Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Herpes simplex virus 1 ICP8 mutant lacking annealing activity is deficient for viral DNA replication. Weerasooriya S, et al. Proc Natl Acad Sci U S A, 2019 Jan 15. PMID 30598436, Free PMC Article
  2. ICP8 Filament Formation Is Essential for Replication Compartment Formation during Herpes Simplex Virus Infection. Darwish AS, et al. J Virol, 2015 Dec 16. PMID 26676794, Free PMC Article
  3. Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication. Bryant KF, et al. J Virol, 2012 Jun. PMID 22491472, Free PMC Article
  4. Determination of HSV-1 UL5 and UL29 gene copy numbers in an HSV complementing Vero cell line. Azizi A, et al. J Biotechnol, 2013 Dec. PMID 24140636
  5. DNA-binding activity of adeno-associated virus Rep is required for inverted terminal repeat-dependent complex formation with herpes simplex virus ICP8. Alex M, et al. J Virol, 2012 Mar. PMID 22205745, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data indicate that the annealing activity of ICP8 is essential for viral DNA replication in the context of infection and support the notion that HSV-1 uses recombination-dependent mechanisms during DNA replication.
    Title: Herpes simplex virus 1 ICP8 mutant lacking annealing activity is deficient for viral DNA replication.
  2. The FNF (F1142, N1143, and F1144) and FW (F843 and W844) motifs are required for ICP8 self-interactions and these interactions may be important for the formation of prereplicative sites and replication compartments.
    Title: ICP8 Filament Formation Is Essential for Replication Compartment Formation during Herpes Simplex Virus Infection.
  3. Results showed that the UL29 and UL5 transgenes are stable in that there are one and three copies of the UL29 and UL5 genes, respectively, per cell in both the AV529-19 MCB and ECB.
    Title: Determination of HSV-1 UL5 and UL29 gene copy numbers in an HSV complementing Vero cell line.
  4. The conserved D and E residues in ICP8 were required for binding metal cations and virus replication.
    Title: Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication.
  5. DNA-binding activity of adeno-associated virus Rep 78 is required for complex formation with herpes simplex virus ICP8.
    Title: DNA-binding activity of adeno-associated virus Rep is required for inverted terminal repeat-dependent complex formation with herpes simplex virus ICP8.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

regulatory

  • Loc: c58415-58410 regulatory_class = polyA_signal_sequence
Preferred Names
single-stranded DNA-binding protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    58410..62054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137104.1 single-stranded DNA-binding protein [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137104.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0B5EDT2, A0A2U9A5R4, A0A5J6DVM3, A0A5J6DWP3, G8HBE3
    Conserved Domains (1) summary
    PHA03362
    Location:4 → 1196
    PHA03362; single-stranded binding protein UL29; Provisional
Nucleotide Protein
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