RL2 contains a RING finger; disrupts ND10; proteasome-dependent degradation of several cellular proteins; involved in gene regulation; involved in cellular protein degradation; involved in latency [Human alphaherpesvirus 1 (Herpes simplex virus type 1)] - Gene

Summary

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Gene symbol: RL2
Gene description: contains a RING finger; disrupts ND10; proteasome-dependent degradation of several cellular proteins; involved in gene regulation; involved in cellular protein degradation; involved in latency
Locus tag: HHV1gp00p17
Gene type: protein coding
RNA name: ubiquitin E3 ligase ICP0
RefSeq status: PROVISIONAL
Organism: Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:: NC_001806.2 (120675..124287, complement)

NC_001806.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001806.2

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSV-1 infection and pathogenesis in the tree shrew eye following corneal inoculation.
Title: HSV-1 infection and pathogenesis in the tree shrew eye following corneal inoculation.
data show that infected cell protein 0 (ICP0) binds CIN85 in a reciprocal manner and that the complexes pulled down by ICP0 also contain Cbl
Title: Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces.
Data suggest that intracellular host defenses are counteracted by ICP0, which targets PML for degradation from the outset of nuclear infection to promote viral-DNA release from PML-nuclear bodies and the onset of HSV-1 lytic replication. (ICP0 = immediate early infected polypeptide-0; PML = promyelocytic leukemia protein; HSV-1 = herpes simplex virus-1)
Title: Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
The Nbs1 homologs that promote herpes simplex virus 1 infection also interact with the herpes simplex virus 1 ICP0 protein.
Title: An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.
no evidence was found that miR-H2 represses the expression of ICP0 in cells or mice infected with HSV-1.
Title: Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia.
An HSV-1 protein, ICP0, can recognize individual host factors and target them differently for destruction. We identified elements that are important for the ICP0 E3 ubiquitin ligase to differentially recognize two of its substrates, isoforms PML I and PML II.
Title: A Tale of Two PMLs: Elements Regulating a Differential Substrate Recognition by the ICP0 E3 Ubiquitin Ligase of Herpes Simplex Virus 1.
Together, these results demonstrate that herpes simplex virus 1 promotes the loss of IFI16 through at least two mechanisms: (i) by ICP0-dependent degradation of IFI16 and (ii) by vhs-dependent turnover of IFI16 mRNA.
Title: Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types.
Overall, these results show that ICP0 promotes histone removal, a reduction of H3K9me3 modifications, and a later indirect reduction of H3K27me3 modifications following viral early gene expression and DNA synthesis.
Title: Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection.
The results showed that ICP0 interacted with cell protein RanBP10, a known transcriptional coactivator, in human herpesvirus 1-infected cells.
Title: Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication.
Our results suggest that miR-H2 downregulates ICP0 and this moderates both HSV-1 neurovirulence and reactivation
Title: A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

regulatory

Loc: c120697-120692 regulatory_class = polyA_signal_sequence
Loc: c124287-124282 regulatory_class = TATA_box

General protein information

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Preferred Names: contains a RING finger; disrupts ND10; proteasome-dependent degradation of several cellular proteins; involved in gene regulation; involved in cellular protein degradation; involved in latency

Names: ubiquitin E3 ligase ICP0

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001806.2 Reference assembly

Range

120675..124287 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_009137133.1 ubiquitin E3 ligase ICP0 [Human alphaherpesvirus 1]

See identical proteins and their annotated locations for YP_009137133.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P08393

UniProtKB/TrEMBL

A0A5J6DWK9, A0A7S4U4A1, G8HBH2

Conserved Domains (3) summary

PRK12323
Location:261 → 451

PRK12323; DNA polymerase III subunit gamma/tau

cd00162
Location:116 → 156

RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]

pfam00097
Location:116 → 156

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)