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UL25 DNA packaging tegument protein UL25 [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703377, updated on 10-Oct-2024

Summary

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Gene symbol
UL25
Gene description
DNA packaging tegument protein UL25
Locus tag
HHV1gp00p51
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (48814..52772)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene envelope glycoprotein H Neighboring gene involved in nucleotide metabolism Neighboring gene nuclear protein UL24 Neighboring gene capsid maturation protease Neighboring gene capsid scaffold protein Neighboring gene envelope glycoprotein B Neighboring gene DNA packaging terminase subunit 2 Neighboring gene single-stranded DNA-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores. Huffman JB, et al. J Virol, 2017 Aug 1. PMID 28490590, Free PMC Article
  2. Structural characterization of the UL25 DNA-packaging protein from herpes simplex virus type 1. Bowman BR, et al. J Virol, 2006 Mar. PMID 16474137, Free PMC Article
  3. The UL25 gene product of herpes simplex virus type 1 is involved in uncoating of the viral genome. Preston VG, et al. J Virol, 2008 Jul. PMID 18448531, Free PMC Article
  4. Major capsid reinforcement by a minor protein in herpesviruses and phage. Sae-Ueng U, et al. Nucleic Acids Res, 2014 Aug. PMID 25053840, Free PMC Article
  5. Role of the UL25 protein in herpes simplex virus DNA encapsidation. Cockrell SK, et al. J Virol, 2009 Jan. PMID 18945788, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate that the pUL25 capsid protein has a critical role in releasing viral DNA from nuclear pore complex-bound capsids.
    Title: The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores.
  2. detailed analyses, including quantitative mass spectrometry of the protein composition of the capsids, revealed that both pUL17 and pUL25 are required to stabilize the capsid shells at the vertices.
    Title: Vertex-Specific Proteins pUL17 and pUL25 Mechanically Reinforce Herpes Simplex Virus Capsids.
  3. Authors showed that in contrast to accepted models, the capsid vertex-specific component is not formed from pUL17 and pUL25 on their own but requires a contribution from pUL36.
    Title: The large tegument protein pUL36 is essential for formation of the capsid vertex-specific component at the capsid-tegument interface of herpes simplex virus 1.
  4. The data reveals that the loosely formed capsid structure is reinforced post-assembly by the minor capsid protein UL25 in HSV-1.
    Title: Major capsid reinforcement by a minor protein in herpesviruses and phage.
  5. Authors hypothesize that the final 20 amino acids of pU(L)25 are required for pU(L)31 to associate with capsids. In the absence of pU(L)25 from the capsid, regions of capsid-associated pU(L)17 are bound by pU(L)31.
    Title: Association of herpes simplex virus pUL31 with capsid vertices and components of the capsid vertex-specific complex.
  6. 2430 to 2893 of HSV1 pUL36, containing one binding site for the capsid protein pUL25, are sufficient to recruit pUL36 onto cytosolic capsids during assembly.
    Title: The C terminus of the large tegument protein pUL36 contains multiple capsid binding sites that function differently during assembly and cell entry of herpes simplex virus.
  7. An interaction between a complex of pU(L)17/pU(L)25, termed the C capsid-specific complex (CCSC), and pU(L)31, a component of the nuclear egress complex (NEC), is reported.
    Title: Selection of HSV capsids for envelopment involves interaction between capsid surface components pUL31, pUL17, and pUL25.
  8. Host C9orf9 promotes viral proliferation via interaction with HSV-1 UL25 protein.
    Title: Host cell protein C9orf69 promotes viral proliferation via interaction with HSV-1 UL25 protein.
  9. Residues 1 to 27 of UL25 contact the hexon adjacent to the penton. A second region, most likely centered on amino acids 26 to 39, contacts the triplex that is one removed from the penton.
    Title: Residues of the UL25 protein of herpes simplex virus that are required for its stable interaction with capsids.
  10. These findings reveal a new role for pUL25 in virion assembly, consistent with its flexible structure and location on the capsid.
    Title: Mutational analysis of the herpes simplex virus type 1 UL25 DNA packaging protein reveals regions that are important after the viral DNA has been packaged.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: 52767-52772 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
DNA packaging tegument protein UL25

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    48814..52772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137099.1 DNA packaging tegument protein UL25 [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137099.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P10209
    UniProtKB/TrEMBL
    A0A181ZGC4, A0A181ZGH7, A0A5J6DVN3, A0A5J6DVY8, D3YPI2, G8HBD8
    Conserved Domains (1) summary
    PHA03248
    Location:1 → 580
    PHA03248; DNA packaging tegument protein UL25; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6CGR_l.1
6CGR_m.1

Gene LinkOut

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