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UL36 large tegument protein [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703357, updated on 16-Jun-2026
Gene symbol
UL36
Gene description
large tegument protein
Locus tag
HHV1gp00p39
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Try the new Transcripts and proteins table
Sequence:
NC_001806.2 (70983..80468, complement)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene DNA polymerase catalytic subunit Neighboring gene nuclear egress lamina protein Neighboring gene DNA packaging protein UL32 Neighboring gene DNA packaging protein UL33 Neighboring gene nuclear egress membrane protein Neighboring gene small capsid protein Neighboring gene tegument protein UL37 Neighboring gene capsid triplex subunit 1

Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells. Mohnke J, et al. J Virol, 2022 Nov 23. PMID 36314822, Free PMC Article
  2. Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus. Jovasevic V, et al. J Virol, 2008 Apr. PMID 18216103, Free PMC Article
  3. UL36p is required for efficient transport of membrane-associated herpes simplex virus type 1 along microtubules. Shanda SK, et al. J Virol, 2008 Aug. PMID 18495763, Free PMC Article
  4. Localization of herpes simplex virus type 1 UL37 in the Golgi complex requires UL36 but not capsid structures. Desai P, et al. J Virol, 2008 Nov. PMID 18787001, Free PMC Article
  5. The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2). Ko DH, et al. J Virol, 2010 Feb. PMID 19923173, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ICP22-defined condensates mediate RNAPII deubiquitylation by UL36 and promote HSV-1 transcription.
    Title: ICP22-defined condensates mediate RNAPII deubiquitylation by UL36 and promote HSV-1 transcription.
  2. pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells.
    Title: pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells.
  3. The findings underline the roles of UL36USP-IFNAR2 interaction in counteracting the type I IFN-mediated signaling pathway and reveal a novel evasion mechanism of antiviral innate immunity by HSV-1.
    Title: Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity.
  4. UL36USP deubiquitinating activity supports HSV-1 virus replication during infection.
    Title: The herpes simplex virus 1 UL36USP deubiquitinase suppresses DNA repair in host cells via deubiquitination of proliferating cell nuclear antigen.
  5. UL36 abrogates NF-kappaB activation by cleaving polyubiquitin chains from IkappaBalpha and therefore restricts proteasome-dependent degradation of IkappaBalpha and that DUB activity is indispensable for this process.
    Title: Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Abrogates NF-κB Activation in DNA Sensing Signal Pathway.
  6. characterized 2 conserved tryptophan-acidic motifs in the central region of pUL36; results indicate the unique conserved tryptophan-acidic motifs in the central region of pUL36 are required for efficient targeting of progeny capsids to the membranes of secondary capsid envelop
    Title: Conserved Tryptophan Motifs in the Large Tegument Protein pUL36 Are Required for Efficient Secondary Envelopment of Herpes Simplex Virus Capsids.
  7. UL36p-independent binding of capsids to organelles occurs prior to the function of UL36p in capsid envelopment.
    Title: Herpes Simplex Virus Capsid-Organelle Association in the Absence of the Large Tegument Protein UL36p.
  8. an essential feature of UL36 is the existence in its central region of a stalk capable of connecting capsid and membrane across the tegument and that the ability to switch between monomeric and dimeric forms may help UL36 fulfill its multiple functions
    Title: Insights into herpesvirus tegument organization from structural analyses of the 970 central residues of HSV-1 UL36 protein.
  9. Authors showed that in contrast to accepted models, the capsid vertex-specific component is not formed from pUL17 and pUL25 on their own but requires a contribution from pUL36.
    Title: The large tegument protein pUL36 is essential for formation of the capsid vertex-specific component at the capsid-tegument interface of herpes simplex virus 1.
  10. In addition, immunoblot analysis suggested that failure to bind pUL37 affected the stability of pUL36.
    Title: The interaction of the HSV-1 tegument proteins pUL36 and pUL37 is essential for secondary envelopment during viral egress.
Submit: New GeneRIF Correction See all GeneRIFs (25)
Products Interactant Other Gene Complex Source Pubs Description

regulatory

  • Loc: c70988-70983 regulatory_class = polyA_signal_sequence
Preferred Names
large tegument protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    70983..80468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137111.1 large tegument protein [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137111.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    B9VQG4, P10220, Q09I97
    UniProtKB/TrEMBL
    G8HBF0
    Conserved Domains (1) summary
    PHA03247
    Location:11 → 3139
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6CGR_n.1
6CGR_o.1

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