FOXB1 forkhead box B1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FOXB1provided by HGNC
Official Full Name: forkhead box B1provided by HGNC
Primary source: HGNC:HGNC:3799
See related: Ensembl:ENSG00000171956
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FKH5; HFKH-5
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all

Genomic context

Location:: 15q22.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	15	NC_000015.10 (60004311..60007444)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (60296421..60298142)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the FOXB1 gene: The FOXB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 280 organisms have orthologs with human gene FOXB1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
DNA-binding transcription factor activity, RNA polymerase II-specific	ISM Inferred from Sequence Model more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
axon target recognition	ISS Inferred from Sequence or Structural Similarity more info
cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell migration in diencephalon	ISS Inferred from Sequence or Structural Similarity more info
epithelial cell differentiation involved in mammary gland alveolus development	ISS Inferred from Sequence or Structural Similarity more info
floor plate development	ISS Inferred from Sequence or Structural Similarity more info
hypothalamus cell migration	ISS Inferred from Sequence or Structural Similarity more info
inferior colliculus development	ISS Inferred from Sequence or Structural Similarity more info
lactation	ISS Inferred from Sequence or Structural Similarity more info
mammary gland lobule development	ISS Inferred from Sequence or Structural Similarity more info
mammillary body development	ISS Inferred from Sequence or Structural Similarity more info
mammillothalamic axonal tract development	ISS Inferred from Sequence or Structural Similarity more info
midbrain development	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
somitogenesis	ISS Inferred from Sequence or Structural Similarity more info
spinal cord development	IEA Inferred from Electronic Annotation more info
telencephalon cell migration	ISS Inferred from Sequence or Structural Similarity more info
thalamus development	IEA Inferred from Electronic Annotation more info
urogenital system development	IEA Inferred from Electronic Annotation more info
visual learning	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
nuclear chromatin	ISA Inferred from Sequence Alignment more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: forkhead box protein B1

Names: transcription factor FKH-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.