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FOXB1 forkhead box B1 [ Homo sapiens (human) ]

Gene ID: 27023, updated on 11-Jun-2021

Summary

Official Symbol
FOXB1provided by HGNC
Official Full Name
forkhead box B1provided by HGNC
Primary source
HGNC:HGNC:3799
See related
Ensembl:ENSG00000171956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKH5; HFKH-5
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See FOXB1 in Genome Data Viewer
Location:
15q22.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (60004311..60007444)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (60296510..60299643)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 18 pseudogene 2 Neighboring gene NMNAT1 pseudogene 5 Neighboring gene uncharacterized LOC105370838 Neighboring gene mesoderm specific transcript pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon target recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration in diencephalon ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial cell differentiation involved in mammary gland alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in floor plate development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hypothalamus cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inferior colliculus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lactation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammary gland lobule development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammillary body development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammillothalamic axonal tract development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in midbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in somitogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spinal cord development IEA
Inferred from Electronic Annotation
more info
 
involved_in telencephalon cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in thalamus development IEA
Inferred from Electronic Annotation
more info
 
involved_in urogenital system development IEA
Inferred from Electronic Annotation
more info
 
involved_in visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
forkhead box protein B1
Names
transcription factor FKH-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012182.3NP_036314.2  forkhead box protein B1

    See identical proteins and their annotated locations for NP_036314.2

    Status: VALIDATED

    Source sequence(s)
    AC009654, AF071554, DA685771
    Consensus CDS
    CCDS32255.1
    UniProtKB/Swiss-Prot
    Q99853
    Related
    ENSP00000379369.4, ENST00000396057.6
    Conserved Domains (1) summary
    cd20043
    Location:1110
    FH_FOXB2; Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    60004311..60007444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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