U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FOXB1 forkhead box B1 [ Homo sapiens (human) ]

Gene ID: 27023, updated on 9-Jun-2025
Official Symbol
FOXB1provided by HGNC
Official Full Name
forkhead box B1provided by HGNC
Primary source
HGNC:HGNC:3799
See related
Ensembl:ENSG00000171956 MIM:619961; AllianceGenome:HGNC:3799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKH5; HFKH-5
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including mammary gland development; nervous system development; and visual learning. Predicted to be located in chromatin and nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See FOXB1 in Genome Data Viewer
Location:
15q22.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (60004311..60007444)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (57805997..57809133)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (60296510..60299643)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 18 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9501 Neighboring gene NMNAT1 pseudogene 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:60287460-60288247 Neighboring gene NANOG hESC enhancer GRCh37_chr15:60296191-60296706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9503 Neighboring gene Sharpr-MPRA regulatory region 13950 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:60301179-60301777 Neighboring gene uncharacterized LOC105370838 Neighboring gene mesoderm specific transcript pseudogene 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axon target recognition IEA
Inferred from Electronic Annotation
more info
 
involved_in axon target recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration in diencephalon IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration in diencephalon ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial cell differentiation involved in mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell differentiation involved in mammary gland alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in floor plate development IEA
Inferred from Electronic Annotation
more info
 
involved_in floor plate development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hypothalamus cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in hypothalamus cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inferior colliculus development IEA
Inferred from Electronic Annotation
more info
 
involved_in inferior colliculus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lactation IEA
Inferred from Electronic Annotation
more info
 
involved_in lactation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammary gland lobule development IEA
Inferred from Electronic Annotation
more info
 
involved_in mammary gland lobule development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammillary body development IEA
Inferred from Electronic Annotation
more info
 
involved_in mammillary body development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammillothalamic axonal tract development IEA
Inferred from Electronic Annotation
more info
 
involved_in mammillothalamic axonal tract development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in midbrain development IEA
Inferred from Electronic Annotation
more info
 
involved_in midbrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in somitogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in somitogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spinal cord development IEA
Inferred from Electronic Annotation
more info
 
involved_in telencephalon cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in telencephalon cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in thalamus development IEA
Inferred from Electronic Annotation
more info
 
involved_in urogenital system development IEA
Inferred from Electronic Annotation
more info
 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
 
involved_in visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
forkhead box protein B1
Names
transcription factor FKH-5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012182.3NP_036314.2  forkhead box protein B1

    See identical proteins and their annotated locations for NP_036314.2

    Status: VALIDATED

    Source sequence(s)
    AC009654, AF071554, DA685771
    Consensus CDS
    CCDS32255.1
    UniProtKB/Swiss-Prot
    O60652, O75917, Q14CL2, Q99853
    Related
    ENSP00000379369.4, ENST00000396057.6
    Conserved Domains (1) summary
    cd20043
    Location:1110
    FH_FOXB2; Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    60004311..60007444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    57805997..57809133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)