Jaml junction adhesion molecule like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jamlprovided by MGI
Official Full Name: junction adhesion molecule likeprovided by MGI
Primary source: MGI:MGI:2685484
See related: Ensembl:ENSMUSG00000048534 AllianceGenome:MGI:2685484
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AMICA; Crea7; Gm638; Amica1
Summary: Predicted to enable integrin binding activity and protein homodimerization activity. Involved in gamma-delta T cell activation and positive regulation of epithelial cell proliferation involved in wound healing. Located in plasma membrane. Orthologous to human JAML (junction adhesion molecule like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9; 9 A5.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44990451..45019829)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (45079153..45108531)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism.
Title: JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism.
JAML promotes CD8 and gammadelta T cell antitumor immunity and is a novel target for cancer immunotherapy.
Title: JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Title: Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
silencing attenuates atherogenesis and enhances plaque stability in ApoE(-/-) mice
Title: Silencing of junctional adhesion molecule-like protein attenuates atherogenesis and enhances plaque stability in ApoE(-/-) mice.
Findings suggest that specific JAM family members play an important role in the transendothelial migration (TEM) of in vitro-generated mouse and human dendritic cells (DCs) from the inoculation site to regional lymph nodes (LNs) in DC-based cancer immunotherapy.
Title: Junctional adhesion molecules mediate transendothelial migration of dendritic cell vaccine in cancer immunotherapy.
crystal structure of the JAML-HL4E10 Fab complex
Title: Molecular insights into γδ T cell costimulation by an anti-JAML antibody.
crystal structure of junctional adhesion molecule-like protein (JAML) and coxsackie and adenovirus receptor; data show how CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase to a JAML intracellular sequence motif
Title: The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K.
identified an epithelial gammadelta T cell costimulatory molecule, junctional adhesion molecule-like protein - JAML; binding of JAML to CAR provides costimulation leading to cell proliferation and cytokine and growth factor production
Title: The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Jaml gene: The Jaml gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 239 organisms have orthologs with human gene Jaml
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in gamma-delta T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in monocyte extravasation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in monocyte extravasation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil extravasation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in neutrophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation involved in wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: junctional adhesion molecule-like

Names: adhesion molecule AMICA; adhesion molecule, interacts with CXADR antigen 1; dendritic cell-specific protein CREA7; dendritic-cell specific protein Crea7; mCrea7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.