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Irf2bp2 interferon regulatory factor 2 binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 270110, updated on 26-Sep-2022

Summary

Official Symbol
Irf2bp2provided by MGI
Official Full Name
interferon regulatory factor 2 binding protein 2provided by MGI
Primary source
MGI:MGI:2443921
See related
Ensembl:ENSMUSG00000051495 AllianceGenome:MGI:2443921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRF-2BP2; E130305N23Rik
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in immature B cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; diaphragm; liver; lung; and musculature. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human IRF2BP2 (interferon regulatory factor 2 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 74.8), ovary adult (RPKM 71.8) and 27 other tissues See more
Orthologs
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Genomic context

See Irf2bp2 in Genome Data Viewer
Location:
8; 8 E2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (127315035..127320725, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (126588296..126593986, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51605 Neighboring gene predicted gene, 39286 Neighboring gene VISTA enhancer mm1295 Neighboring gene predicted gene, 31603

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon regulatory factor 2-binding protein 2
Names
IRF-2-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164598.3NP_001158070.1  interferon regulatory factor 2-binding protein 2

    See identical proteins and their annotated locations for NP_001158070.1

    Status: VALIDATED

    Source sequence(s)
    AC137157
    Consensus CDS
    CCDS52711.1
    UniProtKB/Swiss-Prot
    E9Q1P8, Q8BJC6
    Related
    ENSMUSP00000062753.7, ENSMUST00000054960.9
    Conserved Domains (1) summary
    pfam11261
    Location:1263
    IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    127315035..127320725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)