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Letm2 leucine zipper-EF-hand containing transmembrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 270035, updated on 9-Mar-2023

Summary

Official Symbol
Letm2provided by MGI
Official Full Name
leucine zipper-EF-hand containing transmembrane protein 2provided by MGI
Primary source
MGI:MGI:2444979
See related
Ensembl:ENSMUSG00000037363 AllianceGenome:MGI:2444979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030453H13; D030041N04Rik
Summary
Predicted to enable ribosome binding activity. Predicted to be involved in cellular metal ion homeostasis. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Orthologous to human LETM2 (leucine zipper and EF-hand containing transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 17.6), cerebellum adult (RPKM 2.3) and 8 other tissues See more
Orthologs
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Genomic context

See Letm2 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26068494..26088005, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25578478..25597989, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31288 Neighboring gene fibroblast growth factor receptor 1 Neighboring gene VISTA enhancer mm612 Neighboring gene predicted gene 16159 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene predicted gene, 24992 Neighboring gene phospholipid phosphatase 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
LETM1 domain-containing protein LETM2, mitochondrial
Names
LETM1 and EF-hand domain-containing protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364069.1NP_001350998.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AW048776, BC055685, BE648035, DV647889
    Consensus CDS
    CCDS52527.1
    UniProtKB/Swiss-Prot
    Q7TNU7
    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  2. NM_001364070.1NP_001350999.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156990, AW048776, BC055685, BE648035
    Conserved Domains (1) summary
    pfam07766
    Location:2219
    LETM1; LETM1-like protein
  3. NM_001364071.1NP_001351000.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156990, AW048776, BC055685, BE648035, CJ087333
    Conserved Domains (1) summary
    pfam07766
    Location:2219
    LETM1; LETM1-like protein
  4. NM_173012.3NP_766600.2  LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_766600.2

    Status: VALIDATED

    Source sequence(s)
    AW048776, BC055685, BE648035
    Consensus CDS
    CCDS52527.1
    UniProtKB/Swiss-Prot
    Q7TNU7
    Related
    ENSMUSP00000078160.7, ENSMUST00000079160.8
    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein

RNA

  1. NR_157064.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156990, AC160526, AW048776, BC055685, BE648035

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26068494..26088005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154069.1XP_036009962.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  2. XM_036154074.1XP_036009967.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2219
    LETM1; LETM1-like protein
  3. XM_006509130.5XP_006509193.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2219
    LETM1; LETM1-like protein
  4. XM_036154073.1XP_036009966.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2219
    LETM1; LETM1-like protein
  5. XM_030243591.2XP_030099451.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2219
    LETM1; LETM1-like protein
  6. XM_017312844.3XP_017168333.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2219
    LETM1; LETM1-like protein
  7. XM_036154072.1XP_036009965.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2219
    LETM1; LETM1-like protein
  8. XM_036154068.1XP_036009961.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  9. XM_006509124.5XP_006509187.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006509187.1

    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  10. XM_036154067.1XP_036009960.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  11. XM_030243592.2XP_030099452.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X7

    Conserved Domains (1) summary
    pfam07766
    Location:2204
    LETM1; LETM1-like protein
  12. XM_006509126.4XP_006509189.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006509189.1

    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  13. XM_006509125.4XP_006509188.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006509188.1

    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  14. XM_036154070.1XP_036009963.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    Conserved Domains (1) summary
    pfam07766
    Location:120343
    LETM1; LETM1-like protein
  15. XM_030243590.2XP_030099450.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    Conserved Domains (1) summary
    pfam07766
    Location:120343
    LETM1; LETM1-like protein
  16. XM_006509123.5XP_006509186.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006509186.1

    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  17. XM_036154071.1XP_036009964.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X5

    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  18. XM_011242140.4XP_011240442.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

    See identical proteins and their annotated locations for XP_011240442.1

    Conserved Domains (2) summary
    TIGR04526
    Location:170243
    predic_Ig_block; putative immunoglobulin-blocking virulence protein
    pfam07766
    Location:3163
    LETM1; LETM1-like protein
  19. XM_030243594.2XP_030099454.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X10

    Conserved Domains (1) summary
    pfam07766
    Location:3163
    LETM1; LETM1-like protein
  20. XM_006509128.5XP_006509191.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam07766
    Location:120343
    LETM1; LETM1-like protein
  21. XM_006509127.4XP_006509190.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006509190.1

    UniProtKB/Swiss-Prot
    Q7TNU7
    Conserved Domains (1) summary
    pfam07766
    Location:120383
    LETM1; LETM1-like protein
  22. XM_030243593.1XP_030099453.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X8

    Conserved Domains (1) summary
    pfam07766
    Location:2219
    LETM1; LETM1-like protein

RNA

  1. XR_870217.4 RNA Sequence

  2. XR_003947290.2 RNA Sequence

  3. XR_003947291.2 RNA Sequence

  4. XR_004934835.1 RNA Sequence